Cullin 5 (CUL5) (NM_003478) Human Untagged Clone

CAT#: SC310119

CUL5 (untagged)-Human cullin 5 (CUL5)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CUL5
• Synonyms: CUL-5; VACM-1; VACM1
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_003478 edited
  GTGACGTGGCCGCGGAACCTGAGCTGCGGGGCCTAAGCCGAGCTAAATTCGTTGCAGGTG
  GCCGCGGCGGGTGCAACCACAAAGGCTAATCCGAAGGAGTCGGGGAGGCTCGTGGAGTCG
  ATGCTTCCTCTTCCAAGTCAGGTCGGCTCCCGTTACCTTCTCAGCATTCGCCGTTCCGGT
  CTTCCTGAGCGCGTGCATGAGGTCTTTCGCGTGGGGAAGCTCCGGTGACCATGTAGGGGA
  CAAGAGTGAGGAAGCTCCTGGTGCTTGGGACGAGGTCAGCGCTGTCGGCGCGCTGCTCCA
  GCGCCCACCACACCCTGGTGCGGGCCGACGGGCCCTGGGCCCTGGTGGGAGCTCCGGCCT
  CCGGTCAAGGCCTGGCCGGGAGCGCCACGAATTCTCGCGTCGTCTCGCGAGAGTCCAAGT
  TAAAGAACATGGCGACGTCTAATCTGTTAAAGAATAAAGGTTCTCTTCAGTTTGAAGACA
  AATGGGATTTTATGCGCCCGATTGTTTTGAAGCTTTTACGCCAGGAATCTGTTACAAAAC
  AGCAGTGGTTTGATCTGTTTTCGGATGTGCATGCAGTCTGTCTTTGGGATGATAAAGGCC
  CAGCAAAAATTCATCAGGCTTTAAAAGAAGATATTCTTGAGTTTATTAAGCAGGCACAGG
  CACGAGTACTGAGCCATCAAGATGATACGGCTTTGCTAAAAGCATATATTGTTGAATGGC
  GAAAGTTCTTTACACAATGTGATATTTTACCAAAACCTTTTTGTCAACTAGAGATTACTT
  TAATGGGTAAACAGGGCAGCAATAAAAAATCAAATGTGGAAGACAGTATTGTTCGAAAGC
  TTATGCTTGATACATGGAATGAGTCAATCTTTTCAAACATAAAAAACAGACTCCAAGATA
  GTGCAATGAAGCTGGTACATGCTGAGAGATTGGGAGAAGCTTTTGATTCTCAGCTGGTTA
  TTGGAGTAAGAGAATCCTATGTTAACCTTTGTTCTAATCCTGAGGATAAACTTCAAATTT
  ATAGGGACAATTTTGAGAAGGCATACTTGGATTCAACAGAGAGATTTTATAGAACACAAG
  CACCCTCGTATTTACAACAAAATGGTGTACAGAATTATATGAAATATGCAGATGCTAAAT
  TAAAAGAAGAAGAAAAACGAGCACTACGTTATTTAGAAACAAGACGAGAATGTAACTCCG
  TTGAAGCACTCATGGAATGCTGTGTAAATGCCCTGGTGACATCATTTAAAGAGACTATCT
  TAGCTGAGTGCCAAGGCATGATCAAGAGAAATGAAACTGAAAAATTACATTTAATGTTTT
  CATTGATGGACAAAGTTCCTAATGGTATAGAGCCAATGTTGAAAGACTTGGAGGAACATA
  TCATTAGTGCTGGCCTGGCAGATATGGTAGCAGCTGCTGAAACTATTACTACTGACTCTG
  AGAAATACGTTGAGCAGTTACTTACACTATTTAATAGATTTAGTAAACTCGTCAAAGAAG
  CTTTTCAAGATGATCCACGATTTCTTACTGCAAGAGATAAGGCGTATAAAGCAGTTGTTA
  ATGATGCTACCATATTTAAACTTGAATTACCTTTGAAGCAGAAGGGGGTGGGATTAAAAA
  CTCAGCCTGAATCAAAATGCCCTGAGCTGCTTGCCAATTACTGTGACATGTTGCTAAGAA
  AAACACCATTAAGCAAAAAACTAACCTCTGAAGAGATTGAAGCAAAGCTTAAAGAAGTGC
  TCTTGGTACTTAAGTATGTACAGAACAAAGATGTTTTTATGAGGTATCATAAAGCTCATT
  TGACACGACGTCTTATATTAGACATCTCTGCCGATAGTGAAATTGAAGAAAACATGGTAG
  AGTGGCTAAGAGAAGTTGGTATGCCAGCGGATTATGTAAACAAGCTTGCTAGAATGTTTC
  AGGACATAAAAGTATCTGAAGATTTGAACCAAGCTTTTAAGGAAATGCACAAAAATAATA
  AATTGGCATTACCAGCTGATTCAGTTAATATAAAAATTCTGAATGCTGGCGCCTGGTCAA
  GAAGTTCTGAGAAAGTCTTTGTCTCACTTCCTACTGAACTGGAGGACTTGATACCGGAAG
  TAGAAGAATTCTACAAAAAAAATCATAGTGGTAGAAAATTACATTGGCATCATCTCATGT
  CAAATGGAATTATAACATTTAAGAATGAAGTTGGTCAATATGATTTGGAGGTAACCACGT
  TTCAGCTCGCTGTATTGTTTGCATGGAACCAAAGACCCAGAGAGAAAATCAGCTTTGAAA
  ATCTTAAGCTTGCAACTGAACTCCCTGATGCTGAACTTAGGAGGACTTTATGGTCTTTAG
  TAGCTTTCCCAAAACTCAAACGGCAAGTTTTGTTGTATGAACCTCAAGTCAACTCACCCA
  AAGACTTTACAGAAGGTACCCTCTTCTCAGTGAACCAGGAGTTCAGTTTAATAAAAAATG
  CAAAGGTTCAGAAAAGGGGTAAAATCAACTTGATTGGACGTTTGCAGCTCACTACAGAAA
  GGATGAGAGAAGAAGAGAATGAAGGAATAGTTCAACTACGAATACTAAGAACCCAGGAAG
  CTATCATACAAATAATGAAAATGAGAAAGAAAATTAGTAATGCTCAGCTGCAGACTGAAT
  TAGTAGAAATTTTGAAAAACATGTTCTTGCCACAAAAGAAAATGATAAAAGAGCAAATAG
  AGTGGCTAATAGAGCACAAATACATCAGAAGAGATGAATCTGATATCAACACTTTCATAT
  ATATGGCATAATTTTGAATATCATGGACAATATTTAGAACCCAAATTTTGGAGTGCTTGG
  GCAGAAAGTTGTAAAGTTTGTGCTGGAGAAAGGTTTATTTGGACTTTGATTACATAAATA
  TTAAAATCTCTGCCTTACCTTACAAAAACAACTATATTTTGCCAATCACATTAGTTAGCA
  TGATGGCATTCCCTTCATGTTGCACACTCTTTGACAGCATGCTGTTTTGTGGAGAAACTT
  GCATTCATGAAGAGCCCATTATCAACTTTTAAAAGTGAATTTGATTTGTACCCACCAGGA
  GAAATACAGTTGGGAAGGGTGAGGGTGGGGTTCTTGTTGCTTTTTTCTCTTTTTTCCTCT
  CTTAAAAAATGTACTTGCACAAGGAAGGATCTTCAGATATTCATGCACTGAAAAATGCTG
  TTATCTTTTGTTTTTAAAAAATGCAATTAAAACTAGAAATAGCACTCTTGGTTTCTTTTG
  ATGAAAAGAGTGAGCTGGTCAATGCAACATTGGGAAACGGCAGATGTAGGTGAGAAGTTA
  AGTATTTAATAGTATCAAATTGTTCAAACATTGCTCAGTATAATAACTGGATTTTAATGG
  TGACCTAAAAATGGTATTAAATATTTTCAACTTTCAAATGTTGGTTTTCTTTAAGCAGGA
  GACTGCTATTTTAGTTGTTGTTAAATGATGAGGAGTTTTTTTTTTTTTAAATATGGCTGG
  AAAGCTTGTTTTGAAAAATGAAGCTTATATTAATTGTTGCTTCAATAGTTTAAAAAATTT
  ATGGAGATAGGTAGGTCATTATGATTGCAGAGCCAAAATAGCAAAACAAACATATTAAGT
  GTGTTTACTAAACATATTGTGTGTTTACTAACACACTTAATGTTTATATACCTAATATTT
  ATTATGCCATATCTGAATTTATTAAAAACAACACAGAAATCTCCTGCTCTGATATAGTTA
  TGTAACTGATCTCTTAATCTGTAGCATAGAAGTATTTTGGTATTTTAAGGTCTCATGATT
  AGGGATTTGTAGCCTCAGGTTTGAATCAGTCACCTAGGGGTAAGAGAAAAACCACAACAT
  AAGACCTGAAAAACAGAAGCAAAATTGTTGCACTCTTAATACGAGCAGTAAACTTGCCAA
  ATATATGTACATATATATTTATATATTTTAAAAATAAACATTTTTTAAATCGTCAGAAGG
  CAACATTTACCATGTTCCTTTCAGTCTATCCAAAGTAGCAACTTAACTAGTTGCTGGCAA
  CTGAATACCCAGAGTAGTGGAAATTTTAGGACTTGAGGACGTGAACAACTTGAAAGAGAA
  AATTGATTCCCCTTGAGGAAAGAATGGCTCAACGTGGATTTTTATTCATTGTGGTGCACG
  TTTCAAATTTTCTTGCAAATTATTTTATATCTTATTTGATGTTAAGTAATATTTTTAAAG
  TATGGTTTTTGAAGATAGTAGGAAATGGAGTACAGAAAGGCATACAGTATTATGTTACAG
  TGGAGTGCTTTCAAGAGCATTTCGTAGGATCTGTCCCCATCCGAAGAGGCTTTGTGAACT
  GCCTGCTGAATGGAAGGAAAGCAACTTTAAAACATTTAGAGTTTTGCTGAGTATAGCCAA
  ATGCCTGTTCTGAAACTTATAGGAAATTGGAATTTTGTTTAAAATTTTACACTTTAAGGT
  AGCAAATGTCAATTATTAGACCGAGCATATTGTGAAGAATTAAACTAAAATTAATACGTA
  CAGTTTTCTCTAATTAGGTGACTGTTCATAATGGGTATATTTGGAATTTAGAAGAAATAA
  TTTTGTAGTAATTGTGGCCCTTATGTTTAACAGATAATTCAGCATTGGCGTATTTGCTTG
  TCCCAATACAAGAATGCCAAAGGAGGAAACAGGAAAAATTGCCGTCCATTTTAAAAATTT
  AGGTTTGTTGTTTTAAACCATAATTGTTCTCAGAACTTTTTTGGAACTTCTAATTTTGGG
  TCATTTAATTTAAGAATGAGAGTCATGATGTTTTGATTTATGAAGGTGAATTTAATGCAA
  AAGTGGGTAACACTACATTCATAGCAAAGTTTTTTATTAAATTTTATAAATTTTTAATAG
  CCAATTATGTCCTAATTGTATTTTGGGGAATGAACAGCAGCAAATACTGTAAATGTACAG
  TTTTCTTTTTTTTTTTTTTTGGTTATGTATACAAAAGTTTTAACTACTTTTTGGTGTTTA
  TGAAAATCATTTAGTTGACAAGGTGCCTATGCCATTGTTAAATTTTCTTTAAGTAATTTA
  ACAACAGATTTGCTAATTTAAAAAAAAAAAAAAAAAAAAA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003478
• ORF Size: 2343 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.

Reference Data

• RefSeq: NM_003478.3, NP_003469.2
• RefSeq Size: 6408
• RefSeq ORF: 2343
• Locus ID: 8065
• Domains: CULLIN
• Protein Families: Druggable Genome
• Protein Pathways: Ubiquitin mediated proteolysis
• Gene Summary: Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor. [UniProtKB/Swiss-Prot Function]