ERAP2 (NM_022350) Human Tagged ORF Clone

CAT#: RC213608

ERAP2 (Myc-DDK-tagged)-Human endoplasmic reticulum aminopeptidase 2 (ERAP2), transcript variant 1

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: ERAP2
• Synonyms: L-RAP; LRAP
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RC213608 representing NM_022350
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGTTCCATTCTTCTGCAATGGTTAATTCACACAGAAAACCAATGTTTAACATTCACAGAGGATTTTACT
  GCTTAACAGCCATCTTGCCCCAAATATGCATTTGTTCTCAGTTCTCAGTGCCATCTAGTTATCACTTCAC
  TGAGGATCCCGGGGCTTTCCCAGTAGCCACTAATGGGGAACGATTTCCTTGGCAGGAGCTAAGGCTCCCC
  AGTGTGGTCATTCCTCTCCATTATGACCTCTTTGTCCACCCCAATCTCACCTCTCTGGACTTTGTTGCAT
  CTGAGAAGATCGAAGTCTTGGTCAGCAATGCTACCCAGTTTATCATCTTGCACAGCAAAGATCTTGAAAT
  CACGAATGCCACCCTTCAGTCAGAGGAAGATTCAAGATACATGAAACCAGGAAAAGAACTGAAAGTTTTG
  AGTTACCCTGCTCATGAACAAATTGCACTGCTGGTTCCAGAGAAACTTACGCCTCACCTGAAATACTATG
  TGGCTATGGACTTCCAAGCCAAGTTAGGTGATGGCTTTGAAGGGTTTTATAAAAGCACATACAGAACTCT
  TGGTGGTGAAACAAGAATTCTTGCAGTAACAGATTTTGAGCCAACCCAGGCACGCATGGCTTTCCCTTGC
  TTTGATGAACCGTTGTTCAAAGCCAACTTTTCAATCAAGATACGAAGAGAGAGCAGGCATATTGCACTAT
  CCAACATGCCAAAGGTTAAGACAATTGAACTTGAAGGAGGTCTTTTGGAAGATCACTTTGAAACTACTGT
  AAAAATGAGTACATACCTTGTAGCCTACATAGTTTGTGATTTCCACTCTCTGAGTGGCTTCACTTCATCA
  GGGGTCAAGGTGTCCATCTATGCATCCCCAGACAAACGGAATCAAACACATTATGCTTTGCAGGCATCAC
  TGAAGCTACTTGATTTTTATGAAAAGTACTTTGATATCTACTATCCACTCTCCAAACTGGATTTAATTGC
  TATTCCTGACTTTGCACCTGGAGCCATGGAAAATTGGGGCCTCATTACATATAGGGAGACGTCACTGCTT
  TTTGACCCCAAGACCTCTTCTGCTTCCGATAAACTGTGGGTCACCAGAGTCATAGCCCATGAACTGGCGC
  ACCAGTGGTTTGGCAACCTGGTCACAATGGAATGGTGGAATGATATTTGGCTTAAGGAGGGTTTTGCAAA
  ATACATGGAACTTATCGCTGTTAATGCTACATATCCAGAGCTGCAATTTGATGACTATTTTTTGAATGTG
  TGTTTTGAAGTAATTACAAAAGATTCATTGAATTCATCCCGCCCTATCTCCAAACCAGCGGAAACCCCGA
  CTCAAATACAGGAAATGTTTGATGAAGTTTCCTATAACAAGGGAGCTTGTATTTTGAATATGCTCAAGGA
  TTTTCTGGGTGAGGAGAAATTCCAGAAAGGAATAATTCAGTACTTAAAGAAGTTCAGCTATAGAAATGCT
  AAGAATGATGACTTGTGGAGCAGTCTGTCAAATAGTTGTTTAGAAAGTGATTTTACATCTGGTGGAGTTT
  GTCATTCGGATCCCAAGATGACAAGTAACATGCTCGCCTTTCTGGGGGAAAATGCAGAGGTCAAAGAGAT
  GATGACTACATGGACTCTCCAGAAAGGAATCCCCCTGCTGGTGGTTAAACAAGACGGGTGTTCACTCCGA
  CTGCAACAGGAGCGCTTCCTCCAGGGGGTTTTCCAGGAAGACCCTGAATGGAGGGCCCTGCAGGAGAGGT
  ACCTGTGGCATATCCCATTGACCTACTCCACGAGTTCTTCTAATGTGATCCACAGACACATTCTAAAATC
  AAAGACAGATACTCTGGATCTACCTGAAAAGACCAGTTGGGTGAAATTTAATGTGGACTCAAATGGTTAC
  TACATCGTTCACTATGAGGGTCATGGATGGGACCAACTCATTACACAGCTGAATCAGAACCACACACTTC
  TCAGACCTAAGGACAGAGTAGGTCTGATTCATGATGTGTTTCAGCTAGTTGGTGCAGGGAGACTGACCCT
  AGACAAAGCTCTTGACATGACTTACTACCTCCAACATGAAACAAGCAGCCCCGCACTTCTCGAAGGTCTG
  AGTTACTTGGAATCGTTTTACCACATGATGGACAGAAGGAATATTTCAGATATCTCTGAAAACCTCAAGC
  GTTACCTTCTTCAGTATTTTAAGCCAGTGATTGACAGGCAAAGCTGGAGTGACAAGGGCTCAGTCTGGGA
  CAGGATGCTCCGCTCGGCTCTCTTGAAGCTGGCCTGTGACCTGAACCATGCTCCTTGCATCCAGAAAGCT
  GCTGAACTCTTCTCCCAGTGGATGGAATCCAGTGGAAAATTAAATATACCAACAGATGTTTTAAAGATTG
  TGTATTCTGTGGGTGCTCAGACAACAGCAGGATGGAATTACCTTTTAGAGCAATATGAACTGTCAATGTC
  AAGTGCTGAACAAAACAAAATTCTGTATGCTTTGTCAACGAGCAAGCATCAGGAAAAGTTACTGAAGTTA
  ATTGAACTAGGAATGGAAGGAAAGGTTATCAAGACACAGAACTTGGCAGCTCTCCTTCATGCGATTGCCA
  GACGTCCAAAGGGGCAGCAACTAGCATGGGATTTTGTAAGAGAAAATTGGACCCATCTTCTGAAAAAATT
  TGACTTGGGCTCATATGACATAAGGATGATCATCTCTGGCACAACAGCTCACTTTTCTTCCAAGGATAAG
  TTGCAAGAGGTGAAACTATTTTTTGAATCTCTTGAGGCTCAAGGATCACATCTGGATATTTTTCAAACTG
  TTCTGGAAACGATAACCAAAAATATAAAATGGCTGGAGAAGAATCTTCCGACTCTGAGGACTTGGCTAAT
  GGTTAATACT
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
  Protein Sequence

  >RC213608 representing NM_022350
  Red=Cloning site Green=Tags(s)
  
  MFHSSAMVNSHRKPMFNIHRGFYCLTAILPQICICSQFSVPSSYHFTEDPGAFPVATNGERFPWQELRLP
  SVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNATLQSEEDSRYMKPGKELKVL
  SYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPC
  FDEPLFKANFSIKIRRESRHIALSNMPKVKTIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSS
  GVKVSIYASPDKRNQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLL
  FDPKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQFDDYFLNV
  CFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNA
  KNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLLVVKQDGCSLR
  LQQERFLQGVFQEDPEWRALQERYLWHIPLTYSTSSSNVIHRHILKSKTDTLDLPEKTSWVKFNVDSNGY
  YIVHYEGHGWDQLITQLNQNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGL
  SYLESFYHMMDRRNISDISENLKRYLLQYFKPVIDRQSWSDKGSVWDRMLRSALLKLACDLNHAPCIQKA
  AELFSQWMESSGKLNIPTDVLKIVYSVGAQTTAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKL
  IELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDK
  LQEVKLFFESLEAQGSHLDIFQTVLETITKNIKWLEKNLPTLRTWLMVNT
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_022350
• ORF Size: 2880 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_022350.1, NM_022350.2, NM_022350.3, NM_022350.4, NP_071745.1
• RefSeq Size: 3356
• RefSeq ORF: 2883
• Locus ID: 64167
• Domains: Peptidase_M1
• Protein Families: Druggable Genome, Protease
• MW: 110.3 kDa
• Gene Summary: This gene encodes a zinc metalloaminopeptidase of the M1 protease family that resides in the endoplasmic reticulum and functions in N-terminal trimming antigenic epitopes for presentation by major histocompatibility complex (MHC) class I molecules. Certain mutations in this gene are associated with the inflammatory arthritis syndrome ankylosing spondylitis and pre-eclampsia. This gene is located adjacent to a closely related aminopeptidase gene on chromosome 5. [provided by RefSeq, Jul 2016]