Neurexin II alpha (NRXN2) (NM_138734) Human Tagged ORF Clone

CAT#: RC213626

NRXN2 (Myc-DDK-tagged)-Human neurexin 2 (NRXN2), transcript variant beta

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: NRXN2
• Synonyms: FLJ40892; KIAA0921
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RC213626 representing NM_138734
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGCCCCCCGGGGGGAGCGGGCCGGGGGGGTGCCCGCGCCGCCCCCCGGCCCTGGCTGGGCCCCTGCCGC
  CGCCTCCACCGCCGCCGCCGCCACCTCTGCTGCCGCTGTTGCCGCTGTTGCTGCTGTTGCTGCTGGGGGC
  GGCCGAGGGGGCCCGGGTCTCCTCCAGCCTCAGCACCACCCACCACGTCCACCACTTCCACAGCAAGCAC
  GGCACCGTGCCCATCGCCATCAACCGCATGCCCTTCCTCACCCGCGGCGGCCACGCCGGGACCACATACA
  TCTTTGGGAAGGGGGGAGCGCTCATCACCTACACGTGGCCCCCCAATGACAGGCCCAGCACGAGGATGGA
  TCGCCTGGCCGTGGGCTTCAGCACCCACCAGCGGAGCGCTGTGCTGGTGCGGGTGGACAGCGCCTCCGGC
  CTTGGAGACTACCTGCAGCTGCACATCGACCAGGGCACCGTGGGGGTGATCTTTAACGTGGGCACGGACG
  ACATTACCATCGACGAGCCCAACGCCATAGTAAGCGACGGCAAATACCACGTGGTGCGCTTCACTCGAAG
  CGGCGGCAACGCCACCCTGCAGGTGGACAGCTGGCCGGTCAACGAGCGGTACCCGGCAGGAAACTTTGAT
  AACGAGCGCCTGGCGATTGCTAGACAGAGAATCCCCTACCGGCTTGGTCGAGTAGTAGATGAGTGGCTGC
  TCGACAAAGGCCGCCAGCTGACCATCTTCAACAGCCAGGCTGCCATCAAGATCGGGGGCCGGGATCAGGG
  CCGCCCCTTCCAGGGCCAGGTGTCCGGCCTCTACTACAATGGGCTCAAGGTGCTGGCGCTGGCCGCCGAG
  AGCGACCCCAATGTGCGGACTGAGGGTCACCTGCGCCTGGTGGGGGAGGGGCCGTCCGTGCTGCTCAGTG
  CGGAGACCACGGCCACCACCCTGCTGGCTGACATGGCCACCACCATCATGGAGACTACCACCACCATGGC
  CACTACCACCACGCGCCGGGGCCGCTCCCCCACACTGAGGGACAGCACCACCCAGAACACAGATGACCTG
  CTGGTGGCCTCTGCTGAGTGTCCAAGCGATGATGAGGACCTGGAGGAGTGTGAGCCCAGTACTGGAGGAG
  AGTTAATATTGCCCATTATCACGGAGGACTCCTTAGACCCCCCTCCCGTGGCCACCCGATCCCCCTTCGT
  GCCCCCGCCCCCTACCTTCTACCCCTTCCTCACGGGAGTGGGCGCCACCCAAGACACGCTGCCCCCGCCC
  GCCGCGCGCCGCCCGCCCTCTGGGGGCCCGTGCCAGGCCGAGCGGGACGACAGCGACTGCGAGGAGCCCA
  TCGAGGCCTCGGGCTTCGCCTCCGGGGAGGTCTTTGACTCCAGCCTCCCCCCCACGGACGACGAGGACTT
  TTACACCACCTTTCCCCTGGTCACGGACCGCACCACCCTCCTGTCACCCCGCAAACCCGCTCCCCGGCCC
  AACCTCAGGACAGATGGGGCCACGGGCGCCCCTGGGGTGCTGTTTGCCCCCTCCGCCCCGGCCCCCAACC
  TGCCGGCGGGAAAAATGAACCACCGAGACCCGCTTCAGCCCTTGCTGGAGAACCCGCCCTTGGGGCCCGG
  GGCCCCCACGTCCTTTGAGCCGCGGAGGCCCCCTCCCCTGCGCCCCGGCGTGACCTCAGCCCCCGGCTTC
  CCCCATCTGCCCACAGCCAACCCCACAGGGCCTGGGGAGCGGGGCCCGCCGGGCGCAGTGGAGGTGATCC
  GGGAGTCCAGCAGCACCACGGGCATGGTGGTGGGCATTGTGGCGGCGGCGGCGCTCTGCATCCTCATCCT
  CCTCTACGCCATGTATAAGTACCGCAATCGTGATGAGGGCTCCTACCAGGTGGACCAGAGCCGAAACTAC
  ATCAGTAACTCGGCCCAGAGCAATGGGGCGGTGGTGAAAGAGAAGGCCCCGGCTGCCCCCAAGACGCCCA
  GCAAGGCCAAGAAGAACAAAGACAAGGAGTATTATGTC
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
  Protein Sequence

  >RC213626 representing NM_138734
  Red=Cloning site Green=Tags(s)
  
  MPPGGSGPGGCPRRPPALAGPLPPPPPPPPPPLLPLLPLLLLLLLGAAEGARVSSSLSTTHHVHHFHSKH
  GTVPIAINRMPFLTRGGHAGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASG
  LGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFD
  NERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAE
  SDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRGRSPTLRDSTTQNTDDL
  LVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRSPFVPPPPTFYPFLTGVGATQDTLPPP
  AARRPPSGGPCQAERDDSDCEEPIEASGFASGEVFDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRP
  NLRTDGATGAPGVLFAPSAPAPNLPAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGF
  PHLPTANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNY
  ISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_138734
• ORF Size: 1998 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_138734.1, NM_138734.2, NP_620063.1
• RefSeq Size: 3550
• RefSeq ORF: 2001
• Locus ID: 9379
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs)
• MW: 66.1 kDa
• Gene Summary: This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992). [provided by RefSeq, Jun 2010]