GRAF (ARHGAP26) (NM_015071) Human Tagged ORF Clone

CAT#: RC213996L4

Lenti ORF clone of Human Rho GTPase activating protein 26 (ARHGAP26), transcript variant 1, mGFP tagged

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: mGFP
• Symbol: ARHGAP26
• Synonyms: GRAF; GRAF1; OPHN1L; OPHN1L1
• Vector: pLenti-C-mGFP-P2A-Puro
• E. coli Selection: Chloramphenicol (34 ug/mL)
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC213996).
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene
• ACCN: NM_015071
• ORF Size: 2442 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_015071.2, NP_055886.1
• RefSeq Size: 6518
• RefSeq ORF: 2445
• Locus ID: 23092
• Domains: RhoGAP, SH3, PH
• Protein Families: Druggable Genome
• MW: 92.1 kDa
• Gene Summary: Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]