GRAF (ARHGAP26) (NM_015071) Human Untagged Clone

CAT#: SC114705

ARHGAP26 (untagged)-Human Rho GTPase activating protein 26 (ARHGAP26), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ARHGAP26
• Synonyms: GRAF; GRAF1; OPHN1L; OPHN1L1
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_015071 edited
  ATGGGGCTCCCAGCGCTCGAGTTCAGCGACTGCTGCCTCGATAGTCCGCACTTCCGAGAG
  ACGCTCAAGTCGCACGAAGCAGAGCTGGACAAGACCAACAAATTCATCAAGGAGCTCATC
  AAGGACGGGAAGTCACTCATAAGCGCGCTCAAGAATTTGTCTTCAGCGAAGCGGAAGTTT
  GCAGATTCCTTAAATGAATTTAAATTTCAGTGCATAGGAGATGCAGAAACAGATGATGAG
  ATGTGTATAGCAAGATCTTTGCAGGAGTTTGCCACTGTCCTCAGGAATCTTGAAGATGAA
  CGGATACGGATGATTGAGAATGCCAGCGAGGTGCTCATCACTCCCTTGGAGAAGTTTCGA
  AAGGAACAGATCGGGGCTGCCAAGGAAGCCAAAAAGAAGTATGACAAAGAGACAGAAAAG
  TATTGTGGCATCTTAGAAAAACACTTGAATTTGTCTTCCAAAAAGAAAGAATCTCAGCTT
  CAGGAGGCAGACAGCCAAGTGGACCTGGTCCGGCAGCATTTCTATGAAGTATCCCTGGAA
  TATGTCTTCAAGGTGCAGGAAGTCCAAGAGAGAAAGATGTTTGAGTTTGTGGAGCCTCTG
  CTGGCCTTCCTGCAAGGACTCTTCACTTTCTATCACCATGGTTACGAACTGGCCAAGGAT
  TTCGGGGACTTCAAGACACAGTTAACCATTAGCATACAGAACACAAGAAATCGCTTTGAA
  GGCACTAGATCAGAAGTGGAATCACTGATGAAAAAGATGAAGGAGAATCCCCTTGAGCAC
  AAGACCATCAGTCCCTACACCATGGAGGGATACCTCTACGTGCAGGAGAAACGTCACTTT
  GGAACTTCTTGGGTGAAGCACTACTGTACATATCAACGGGATTCCAAACAAATCACCATG
  GTACCATTTGACCAAAAGTCAGGAGGAAAAGGGGGAGAAGATGAATCAGTTATCCTCAAA
  TCCTGCACACGGCGGAAAACAGACTCCATTGAGAAGAGGTTTTGCTTTGATGTGGAAGCA
  GTAGACAGGCCAGGGGTTATCACCATGCAAGCTTTGTCGGAAGAGGACCGGAGGCTCTGG
  ATGGAAGCCATGGATGGCCGGGAACCTGTCTACAACTCGAACAAAGACAGCCAGAGTGAA
  GGGACTGCGCAGTTGGACAGCATTGGCTTCAGCATAATCAGGAAATGCATCCATGCTGTG
  GAAACCAGAGGGATCAACGAGCAAGGGCTGTATCGAATTGTGGGTGTCAACTCCAGAGTG
  CAGAAGTTGCTGAGTGTCCTGATGGACCCCAAGACTGCTTCTGAGACAGAAACAGATATC
  TGTGCTGAATGGGAGATAAAGACCATCACTAGTGCTCTGAAGACCTACCTAAGAATGCTT
  CCAGGACCACTCATGATGTACCAGTTTCAAAGAAGTTTCATCAAAGCAGCAAAACTGGAG
  AACCAGGAGTCTCGGGTCTCTGAAATCCACAGCCTTGTTCATCGGCTCCCAGAGAAAAAT
  CGGCAGATGTTACAGCTGCTCATGAACCACTTGGCAAATGTTGCTAACAACCACAAGCAG
  AATTTGATGACGGTGGCAAACCTTGGTGTGGTGTTTGGACCCACTCTGCTGAGGCCTCAG
  GAAGAAACAGTAGCAGCCATCATGGACATCAAATTTCAGAACATTGTCATTGAGATCCTA
  ATAGAAAACCACGAAAAGATATTTAACACCGTGCCCGATATGCCTCTCACCAATGCCCAG
  CTGCACCTGTCTCGGAAGAAGAGCAGTGACTCCAAGCCCCCGTCCTGCAGCGAGAGGCCC
  CTGACGCTCTTCCACACCGTTCAGTCAACAGAGAAACAGGAACAAAGGAACAGCATCATC
  AACTCCAGTTTGGAATCTGTCTCATCAAATCCAAACAGCATCCTTAATTCCAGCAGCAGC
  TTACAGCCCAACATGAACTCCAGTGACCCAGACCTGGCTGTGGTCAAACCCACCCGGCCC
  AACTCACTCCCCCCGAATCCAAGCCCAACTTCACCCCTCTCGCCATCTTGGCCCATGTTC
  TCGGCGCCATCCAGCCCTATGCCCACCTCATCCACGTCCAGCGACTCATCCCCCGTCAGG
  TCTGTTGCAGGGTTTGTTTGGTTTTCTGTTGCTGCCGTTGTTCTCTCATTGGCTCGGTCC
  TCTCTTCATGCAGTGTTCAGCCTCCTCGTCAACTTTGTTCCCTGCCATCCAAACCTGCAC
  TTGCTTTTTGACAGGCCAGAAGAAGCGGTACATGAAGACTCCAGCACACCGTTCCGGAAG
  GCAAAAGCCTTGTATGCCTGCAAAGCTGAACATGACTCAGAACTTTCGTTCACAGCAGGC
  ACGGTCTTCGATAATGTTCACCCATCTCAGGAGCCTGGCTGGTTGGAGGGGACTCTGAAC
  GGAAAGACTGGCCTCATCCCTGAGAATTACGTGGAGTTCCTCTAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_015071 unedited
  TCAGATTATGTAATACGACTCACTTATAGGGCGGCCGCGAATTCGCACGAGCTCGAGGCT
  GCCGAGAGCTAGCTAGCGAAGGAGGCGGGGAGGCGGCGTCTGCGCTCGCCCGCTCGCTCG
  CTTCCCGGCGCCGCTGCGGGTCCGCGCTGCGTTTCCTGCTCGCGATCCGCTCCGTTGCCC
  GCGCCCGGAACAGCAGCACCTCGGCCGGGTCCGAGCTCGGTTCGGGAGTCTTGCGCGCCG
  GCGGACACCGCGCGCGGAGTGAGCCAGCACCACACCTGTGGAGCCGGCGGCCGTCGGGGG
  AGCCGGCCGGGGTCCCGCCGCGTGAGTGCTCTGGGCGGCGGGCGGCCCGGGCCCCGGCGG
  AGGCGCGCCCCCCGGCTGGGCGCCGCGCGCACCATGGGGCTCCCAGCGCTCGAGTTCAGC
  GACTGCTGCCTCGATAGTCCGCACTTCCGAGAGACGCTCAAGTCGCACGAAGCAGAGCTG
  GACAAGACCAACAAATTCATCAAGGAGCTCATCAAGGACGGGAAGTCACTCATAAGCGCG
  CTCAAGAATTTGTCTTCAGCGAAGCGGAAGTTTGCAGATTCCTTAAATGAANTTAAATTT
  CAGTGCATAGGAGATGCAGAAACAGATGATGAGATGTGTATAGCAAGATCTTTGCAGGAG
  TTTGCCACTGTCCTCAGGAATCTTGAAGATGAACGGATACGGATGATTGAGAATGCCAGC
  GAGGTGCTCATCACTCCCTTGGAGAAAGTTCCGAAGGGACCAGATCGGGCTGCCAAGGAG
  CCAAAAAGAGTATGACAAGAGACAGAAAGTATGGGGCATCTTAGAAAACACTTGAATTGT
  CTCCAAAAAGAAGAATCCACCTTCAGAGCAGACAGCCAGTGGACCTGGTCCGCAGCATTC
  TTATGAGATTCCTGGATATGCTTCAGGTGCAGCAGTCCAAGGAGAAGAGTTGG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_015071 unedited
  CGTTGCCCGCGGCCGCAATCTACAGTCGAGTTTTTTTTTTTTTTTTTTAAAGTTCCCTAA
  CAAGGAATTCCAGAAACAGGAAACACTCTGAAGCAACGCTGCCATCCAAGGGGCTCCTGG
  GGAGCTTGACGGTCCATCGGTTTGTAGTTTGTCTAGAGTCACCCTTGCAATGACATTCAC
  ATGTGGAAGATACGGATAACTCTGTTGTTTGCAGGCCAAGTGAATTTGAAATCTCCAGGT
  AGTACTTCCCCATCCAAGATTTTTTTTCACAAGATCCAGCCTCTTTTCACCAGCAAATTC
  CCTTTTTCAGAGGGTACTCATACCACCCTACAACCTTGGGTTACTTCCTGAATCACAATG
  GCCTATCTTACCCCCAAGTTTTGCAAGACTGCCAAATATTTTCCTTCCCTCCCAGCGCCC
  CACACCCCCCCTGTGCCCCCTCACCCCTCTCTCCCCTCCAGTATGATCCCCCCTCCCCCG
  TTGCTCATCCCCCCTTCCCCCTCCCCACCTTCCCCCCCCCCAAACCAACCCCTTGCTCCT
  TTTCCCCTCCCTCTCCCCCCATTTCCACCTCTCCCCCACCTCCCCCCCCCCATCTACCAC
  ACCCTACTCCTCCTTTCTCCTTCCCCTCCTCCCTCCACCCCTCTCTTCCCCTTCCTCGCT
  CCTCCCCGACCCCCCCCCCCCTCCCTACCAACTCAAACTCCCATCCCCCCTCTCCGCTCC
  CCTATCCCCCTCCCCCCCAATCTCCCTTCCCACCTTATATCATCCCTATCCACCCCTTCC
  CCTTCGATTCCCTCTATCTCTTCTCTCTCCCTTTCTACCCCTCCACCCCTCGCCATATCC
  ACCTCCCCATCTACACTCCCTCCCCCCGCCTCCCTTCTCATCCCTCCTCTATCCCCACAC
  TCCCCCCCGCACCCTCCCTATATATCCCCTCCCCCCCCCTCGCCGCACACCATATCGCTC
  CACCCCTCCCCTCCCTACCTCAGTTCTCTCGATCTCCNTCCACCAATCTCCGCACCTCTC
  CTTTCTCCTCTGCTTCCGTTCCCG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_015071
• ORF Size: 2445 bp
• Insert Size: 4700
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_015071.2, NP_055886.1
• RefSeq Size: 6518
• RefSeq ORF: 2445
• Locus ID: 23092
• Domains: RhoGAP, SH3, PH
• Protein Families: Druggable Genome
• Gene Summary: Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.