CLCN3 (NM_001829) Human Tagged ORF Clone
CAT#: RC214128L4
- LentiORF®
Lenti-ORF clone of CLCN3 (mGFP-tagged)-Human chloride channel 3 (CLCN3), transcript variant b
"NM_001829" in other vectors (4)
Product Images
Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | mGFP |
Symbol | CLCN3 |
Synonyms | ClC-3; CLC3 |
Vector | pLenti-C-mGFP-P2A-Puro |
E. coli Selection | Chloramphenicol (34 ug/mL) |
Mammalian Cell Selection | Puromycin |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC214128).
|
Restriction Sites | AscI-MluI Cloning Scheme for this gene |
ACCN | NM_001829 |
ORF Size | 2454 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_001829.2, NP_001820.2 |
RefSeq Size | 3982 |
RefSeq ORF | 2457 |
Locus ID | 1182 |
Domains | CBS, voltage_CLC |
Protein Families | Druggable Genome, Ion Channels: Other, Transmembrane |
MW | 90.8 kDa |
Gene Summary | This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
SC110856 | CLCN3 (untagged)-Human chloride channel 3 (CLCN3), transcript variant b |
USD 1,650.00 |
|
RC214128 | CLCN3 (Myc-DDK-tagged)-Human chloride channel 3 (CLCN3), transcript variant b |
USD 910.00 |
|
RG214128 | CLCN3 (GFP-tagged) - Human chloride channel 3 (CLCN3), transcript variant b |
USD 1,000.00 |
|
RC214128L3 | Lenti-ORF clone of CLCN3 (Myc-DDK-tagged)-Human chloride channel 3 (CLCN3), transcript variant b |
USD 1,110.00 |
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