CLCN3 (NM_001829) Human Untagged Clone

CAT#: SC110856

CLCN3 (untagged)-Human chloride channel 3 (CLCN3), transcript variant b


  "NM_001829" in other vectors (4)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol CLCN3
Synonyms ClC-3; CLC3
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF sequence for NM_001829 edited
GAGGCTTTCCCAGTGTTCTAGTTCGCCCGTGACCCGGAATAATGAGCAAGGAGGGTGTGG
TGGGTTGAAAGCCATCCTACTTTACTCCCGAGTTAGAGCATGGATTCAGTTTTAGTCTTA
AGGGGGAAGTGAGATTGGAGATTTTTATTTTTAATTTTGGGCAGAAGCAGGTTGACTCTA
GGGATCTCCAGAGCGAGAGGATTTAACTTCATGTTGCTCCCGTGTTTGAAGGAGGACAAT
AAAAGTCCCACCGGGCAAAATTTTCGTAACCTCTGCGGTAGAAAACGTCAGGTATCTTTT
AAATCGCGATAGTTTTCGCTGTGTCAGGCTTTCTTCGGTGGAGCTCCGAGGGTAGCTAGG
TTCTAGGTTTGAAACAGATGCAGAATCCAAAGGCAGCGCAAAAAACAGCCACCGATTTTG
CTATGTCTCTGAGCTGCGAGATAATCAGACAGCTAAATGGAGTCTGAGCAGCTGTTCCAT
AGAGGCTACTATAGAAACAGCTACAACAGTATAACAAGTGCAAGTAGTGATGAGGAACTT
TTAGATGGAGCAGGTGTTATTATGGACTTTCAAACATCTGAAGATGACAATTTATTAGAT
GGTGACACTGCAGTTGGAACTCATTATACAATGACAAATGGAGGCAGCATTAACAGTTCT
ACACATTTACTGGATCTTTTGGATGAACCAATTCCAGGTGTTGGTACATATGATGATTTC
CATACTATTGATTGGGTGCGAGAAAAATGTAAAGACAGAGAAAGGCATAGACGGATCAAC
AGCAAAAAGAAAGAATCAGCATGGGAAATGACAAAAAGTTTGTATGATGCGTGGTCAGGA
TGGCTAGTAGTAACACTAACAGGATTGGCATCAGGGGCACTGGCCGGATTAATAGACATT
GCTGCCGATTGGATGACTGACCTAAAGGAGGGCATTTGCCTTAGTGCGTTGTGGTACAAC
CACGAACAGTGCTGTTGGGGATCTAATGAAACAACATTTGAAGAGAGGGATAAATGTCCA
CAGTGGAAAACATGGGCAGAATTAATCATAGGTCAAGCAGAGGGTCCTGGTTCTTATATC
ATGAACTACATAATGTACATCTTCTGGGCCTTGAGTTTTGCCTTTCTTGCAGTTTCCCTG
GTAAAGGTATTTGCTCCATATGCCTGTGGCTCTGGAATTCCAGAGATTAAAACTATTTTA
AGTGGATTCATCATCAGAGGTTACTTGGGAAAATGGACTTTAATGATTAAAACCATCACA
TTAGTCCTGGCTGTGGCATCAGGTTTGAGTTTAGGAAAAGAAGGTCCCCTGGTACATGTT
GCCTGTTGCTGCGGAAATATCTTTTCCTACCTCTTTCCAAAGTATAGCACAAACGAAGCT
AAAAAAAGGGAGGTGCTATCAGCTGCCTCAGCTGCAGGGGTTTCTGTAGCTTTTGGTGCA
CCAATTGGAGGAGTTCTTTTTAGCCTGGAAGAGGTTAGCTATTATTTTCCTCTCAAAACT
TTATGGAGATCATTTTTTGCTGCTTTAGTGGCTGCATTTGTTTTGAGGTCCATCAATCCA
TTTGGTAACAGCCGTCTGGTCCTTTTTTATGTGGAGTATCATACACCATGGTACCTTTTT
GAACTGTTTCCTTTTATTCTTCTAGGGGTATTTGGAGGGCTTTGGGGAGCCTTTTTCATT
AGGGCAAATATTGCCTGGTGTCGTCGACGCAAGTCCACGAAATTTGGAAAGTATCCCGTT
CTGGAAGTCATTATTGTTGCAGCCATTACTGCTGTGATAGCCTTCCCTAATCCATACACT
AGGCTAAACACCAGTGAACTGATCAAAGAGCTTTTTACAGACTGTGGTCCCCTGGAATCC
TCTTCTCTTTGTGACTACAGAAATGACATGAATGCCAGTAAAATTGTCGATGACATTCCT
GATCGTCCAGCAGGCATTGGAGTATATTCAGCTATATGGCAGTTATGCCTGGCACTCATA
TTTAAAATCATAATGACAGTATTCACTTTTGGCATCAAGGTTCCATCAGGCTTGTTCATC
CCCAGCATGGCCATTGGAGCGATCGCAGGAAGGATTGTGGGGATTGCGGTGGAGCAGCTT
GCCTACTATCACCACGACTGGTTTATCTTTAAGGAGTGGTGTGAGGTCGGGGCTGATTGC
ATTACACCTGGCCTTTATGCCATGGTTGGTGCTGCTGCATGCTTAGGTGGTGTGACAAGA
ATGACTGTCTCCCTGGTGGTTATTGTTTTTGAGCTTACTGGAGGCTTGGAATATATTGTT
CCCCTTATGGCTGCAGTCATGACCAGTAAATGGGTTGGAGATGCCTTTGGCAGGGAAGGC
ATTTATGAAGCACACATCCGATTAAATGGATACCCTTTCTTGGATGCAAAAGAAGAATTC
ACTCATACCACCCTGGCTGCTGACGTTATGAGACCTCGAAGGAATGATCCTCCCTTAGCT
GTCCTGACACAGGACAATATGACAGTGGATGATATAGAAAACATGATTAATGAAACCAGC
TACAATGGATTTCCTGTCATAATGTCAAAAGAATCTCAGAGATTAGTGGGATTTGCCCTC
AGAAGAGACCTGACAATTGCAATAGAAAGTGCCAGGAAAAAACAAGAAGGTATCGTTGGC
AGTTCTCGGGTGTGTTTTGCACAGCACACCCCATCTCTTCCAGCAGAAAGTCCTCGGCCA
TTGAAGCTTCGAAGCATTCTTGACATGAGCCCTTTTACAGTGACAGACCACACCCCAATG
GAGATCGTGGTGGATATTTTCCGAAAGCTGGGACTGAGGCAGTGCCTTGTAACTCACAAT
GGGCGCCTCCTTGGCATTATAACAAAAAAAGATATCCTCCGGCATATGGCCCAGACGGCA
AACCAAGACCCCGCTTCAATAATGTTCAACTGAATCTCACAGATGAGGAGAGAGAAGAAA
CGGAAGAGGAAGTTTATTTGTTGAATAGCACAACTCTTTAACCTGAGGGAGTCATCTACT
TTTTTTTCCTCCTTTACAAAAAAAGAAAGGAAATATAAAAGCCGGGTTTTTGCAACATGG
TTTGCAAATAATGCTGGTGGAATGGAGGAGTTGTTTGGGGAGGGAAAGGAGAGAGAAGGA
AAGGAGTGAAGGGTATTTCCCGTCTAACAGAAAGCAGCGTATCAACTCCTATTGTTCTGC
ACTGGATGCATTCAGCTGAGGATGTGCCTGATAGTGCAGGCTTGCGCCTCAACAGAGATG
ACAGCAGAGTCCTCGAGCACCTGGCCTGTTGCTCCAACATTGCAAAGA
>OriGene 5' read for NM_001829 unedited
GCCCATTTAGTTATACGACTCACTATAGGCGGCCGCGNAATTCGCACGAGGCTTTCCCAG
TGTTCTAGTTCGCCCGTGACCCGGGATAATGAGCAAGGAGGGTGTGGTGGGTTGAAAGCC
ATCCTACTTTACTCCCGAGTTAGAGCATGGATTCAGTTTTAGTCTTAAGGGGGAAGTGAG
ATTGGAGATTTTTATTTTTAATTTTGGGCAGAAGCAGGTTGACTCTAGGGATCTCCAGAG
CGAGAGGATTTAACTTCATGTTGCTCCCGTGTTTGAAGGAGGACAATAAAAGTCCCACCG
GGCAAAATTTTCGTAACCTCTGCGGTAGAAAACGTCAGGTATCTTTTAAATCGCGATAGT
TTTCGCTGTGTCAGGCTTTCTTCGGTGGAGCTCCGAGGGTAGCTAGGTTCTAGGTTTGAA
ACAGATGCAGAATCCAAAGGCAGCGCAAAAAACAGCCACCGATTTTGCTATGTCTCTGAG
CTGCGAGATAATCAGACAGCTAAATGGAGTCTGAGCAGCTGTTCCATAGAGGCTACTATA
GAAACAGCTACAACAGTATAACAAGTGCAAGTAGTGATGAGGAACTTTTAGATGGAGCAG
GTGTTATTATGGACTTTCAAACATCTGAAGATGACCATTTATTAGATGGTGACACTGCAG
TTGGAACTCATTATACCATGACAAATGGAGGCAGCATTAACAGTTCTACACATTTACTGG
ATCTTTTGGATGACCCATTCCAGTGTTGGTACATATGATGATTTCCATACTATTGGATGG
GTGCCAGAAAATGCTAAGACAGAGAAGGCATATACGGGTCAACAGCAAAAAGAAGAATCA
GCCTGGGAAATGACACAAGTTNGTTTGATGCGCTGTCCAGAGGCCTCTANTAACACTACC
AGATGGCCTCAGGGCCCTGGCCCGATAATGGACACTGCG
>OriGene 3' read for NM_001829 unedited
GGGTTAGCTTGNCCGCGGCCGCATTCTANGATCGAGTTTTTTTTTTTTTTTTTTGTATTT
TATAAATTTTAATCCATAAAAATATAAATAAGAATGGTAAATTTTTAAGAAAAAAAATAT
ACATTTAGTGCAAGTTATGAATTACATTTCTTCTTCAGTGTCAGCCATGAGACATCTTGA
GAAAAGAAAAGAATGACTGATCTAATTTCAATTTTAAAAATTCCAGTGTTTTAACATGCA
ATTAATACCAGATACAGCTAATCAGAATACTTCCTTCTCTTTACTGTCAAAGCAGCAGCA
TTTTATTTAATTATGCTCAACAGCACTTGTATATCATAGTAGTAGTCTTAGAAATAGAAA
ATTTGCATAAGACCCGGTCACATTATCCATAAAGTCTGAGAGGAAAACAAAAAAGAAAAC
TTTATCCTTTAAAACCAAGCTTCATTGTTTTCGGTTTTGATCCACACGGCACACAATGAG
AGATTTCGTTCTCGCTTCCTTCGAGACTTTACCTGTTTGATGAGCCTTTGTTGTGGTGCA
TGTGTACTGTTCCAAGCATTTAGTGATGGTACAAACTACATGGTTAATGGCACAAGAAAC
ACTCCCTTCTTGTGATGAAACCTCAGTAAAATCACAGTACATCTCAATATGAGAAAGGAC
TGCTTCAAAAGGATACACCGATTTAAAGAGGCTTTGTTACAGCTCACTCNAGAGAGAGAG
AGAGAGAGAGAGAGAGAAATAAAGGCTCTTCTGGAATGTAGAAAGGGTATGGCTTAACTA
TACAATTCATGAATTAAACAGAACAGTTTTGATTAAAAAAAAAGGCCAGCACCTTGCAAG
TTTATAGATGGCTCAATTCCAAAGTATCCCTTCTAGAATAGGGACCTGATATGTGTCTTT
GCATGTTGAACTCACAGCCCAGTGCTCGAGGACTCTGCTGTCATTC
Restriction Sites NotI-NotI     
ACCN NM_001829
ORF Size 2457 bp
Insert Size 4200
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_001829.2, NP_001820.2
RefSeq Size 3982
RefSeq ORF 2457
Locus ID 1182
Domains CBS, voltage_CLC
Protein Families Druggable Genome, Ion Channels: Other, Transmembrane
Gene Summary This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Transcript Variant: This variant (b) represents the predominant transcript and encodes isoform b. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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