ARNTL2 (NM_020183) Human Tagged ORF Clone

CAT#: RC216969

ARNTL2 (Myc-DDK-tagged)-Human aryl hydrocarbon receptor nuclear translocator-like 2 (ARNTL2)

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: ARNTL2
• Synonyms: bHLHe6; BMAL2; CLIF; MOP9; PASD9
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RC216969 representing NM_020183
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGCGGCGGAAGAGGAGGCTGCGGCGGGAGGTAAAGTGTTGAGAGAGGAGAACCAGTGCATTGCTCCTG
  TGGTTTCCAGCCGCGTGAGTCCAGGGACAAGACCAACAGCTATGGGGTCTTTCAGCTCACACATGACAGA
  GTTTCCACGAAAACGCAAAGGAAGTGATTCAGACCCATCCCAGTCAGGAATCATGACAGAAAAAGTGGTG
  GAAAAGCTTTCTCAGAATCCCCTTACCTATCTTCTTTCAACAAGGATAGAAATATCAGCCTCCAGTGGCA
  GCAGAGTGGAAGATGGTGAACACCAAGTTAAAATGAAGGCCTTCAGAGAAGCTCATAGCCAAACTGAAAA
  GCGGAGGAGAGATAAAATGAATAACCTGATTGAAGAACTGTCTGCAATGATCCCTCAGTGCAACCCCATG
  GCGCGTAAACTGGACAAACTTACAGTTTTAAGAATGGCTGTTCAACACTTGAGATCTTTAAAAGGCTTGA
  CAAATTCTTATGTGGGAAGTAATTATAGACCATCATTTCTTCAGGATAATGAGCTCAGACATTTAATCCT
  TAAGACTGCAGAAGGCTTCTTATTTGTGGTTGGATGTGAAAGAGGAAAAATTCTCTTCGTTTCTAAGTCA
  GTCTCCAAAATACTTAATTATGATCAGGCTAGTTTGACTGGACAAAGCTTATTTGACTTCTTACATCCAA
  AAGATGTTGCCAAAGTAAAGGAACAACTTTCTTCTTTTGATATTTCACCAAGAGAAAAGCTAATAGATGC
  CAAAACTGGTTTGCAAGTTCACAGTAATCTCCACGCTGGAAGGACACGTGTGTATTCTGGCTCAAGACGA
  TCTTTTTTCTGTCGGATAAAGAGTTGTAAAATCTCTGTCAAAGAAGAGCATGGATGCTTACCCAACTCAA
  AGAAGAAAGAGCACAGAAAATTCTATACTATCCATTGCACTGGTTACTTGAGAAGCTGGCCTCCAAATAT
  TGTTGGAATGGAAGAAGAAAGGAACAGTAAGAAAGACAACAGTAATTTTACCTGCCTTGTGGCCATTGGA
  AGATTACAGCCATATATTGTTCCACAGAACAGTGGAGAGATTAATGTGAAACCAACTGAATTTATAACCC
  GGTTTGCAGTGAATGGAAAATTTGTCTATGTAGATCAAAGGGCAACAGCGATTTTAGGATATCTGCCTCA
  GGAACTTTTGGGAACTTCTTGTTATGAATATTTTCATCAAGATGACCACAATAATTTGACTGACAAGCAC
  AAAGCAGTTCTACAGAGTAAGGAGAAAATACTTACAGATTCCTACAAATTCAGAGCAAAAGATGGCTCTT
  TTGTAACTTTAAAAAGCCAATGGTTTAGTTTCACAAATCCTTGGACAAAAGAACTGGAATATATTGTATC
  TGTCAACACTTTAGTTTTGGGACATAGTGAGCCTGGAGAAGCATCATTTTTACCTTGTAGCTCTCAATCA
  TCAGAAGAATCCTCTAGACAGTCCTGTATGAGTGTACCTGGAATGTCTACTGGAACAGTACTTGGTGCTG
  GTAGTATTGGAACAGATATTGCAAATGAAATTCTGGATTTACAGAGGTTACAGTCTTCTTCATACCTTGA
  TGATTCGAGTCCAACAGGTTTAATGAAAGATACTCATACTGTAAACTGCAGGAGTATGTCAAATAAGGAG
  TTGTTTCCACCAAGTCCTTCTGAAATGGGGGAGCTAGAGGCTACCAGGCAAAACCAGAGTACTGTTGCTG
  TCCACAGCCATGAGCCACTCCTCAGTGATGGTGCACAGTTGGATTTCGATGCCCTATGTGACAATGATGA
  CACAGCCATGGCTGCATTTATGAATTACTTAGAAGCAGAGGGGGGCCTGGGAGACCCTGGGGACTTCAGT
  GACATCCAGTGGACCCTC
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
  Protein Sequence

  >RC216969 representing NM_020183
  Red=Cloning site Green=Tags(s)
  
  MAAEEEAAAGGKVLREENQCIAPVVSSRVSPGTRPTAMGSFSSHMTEFPRKRKGSDSDPSQSGIMTEKVV
  EKLSQNPLTYLLSTRIEISASSGSRVEDGEHQVKMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPM
  ARKLDKLTVLRMAVQHLRSLKGLTNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKS
  VSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRR
  SFFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIG
  RLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKH
  KAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTLVLGHSEPGEASFLPCSSQS
  SEESSRQSCMSVPGMSTGTVLGAGSIGTDIANEILDLQRLQSSSYLDDSSPTGLMKDTHTVNCRSMSNKE
  LFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFS
  DIQWTL
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_020183
• ORF Size: 1908 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_020183.3, NM_020183.4, NP_064568.3
• RefSeq Size: 1930
• RefSeq ORF: 1911
• Locus ID: 56938
• Domains: PAS, HLH
• Protein Families: Druggable Genome, Transcription Factors
• MW: 70.7 kDa
• Gene Summary: This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]