ABCC11 (NM_145186) Human Tagged ORF Clone

CAT#: RC217370

ABCC11 (Myc-DDK-tagged)-Human ATP-binding cassette, sub-family C (CFTR/MRP), member 11 (ABCC11), transcript variant 3

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: ABCC11
• Synonyms: EWWD; MRP8; WW
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RC217370 representing NM_145186
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGACTAGGAAGAGGACATACTGGGTGCCCAACTCTTCTGGTGGCCTCGTGAATCGTGGCATCGACATAG
  GCGATGACATGGTTTCAGGACTTATTTATAAAACCTATACTCTCCAAGATGGCCCCTGGAGTCAGCAAGA
  GAGAAATCCTGAGGCTCCAGGGAGGGCAGCTGTCCCACCGTGGGGGAAGTATGATGCTGCCTTGAGAACC
  ATGATTCCCTTCCGTCCCAAGCCGAGGTTTCCTGCCCCCCAGCCCCTGGACAATGCTGGCCTGTTCTCCT
  ACCTCACCGTGTCATGGCTCACCCCGCTCATGATCCAAAGCTTACGGAGTCGCTTAGATGAGAACACCAT
  CCCTCCACTGTCAGTCCATGATGCCTCAGACAAAAATGTCCAAAGGCTTCACCGCCTTTGGGAAGAAGAA
  GTCTCAAGGCGAGGGATTGAAAAAGCTTCAGTGCTTCTGGTGATGCTGAGGTTCCAGAGAACAAGGTTGA
  TTTTCGATGCACTTCTGGGCATCTGCTTCTGCATTGCCAGTGTACTCGGGCCAATATTGATTATACCAAA
  GATCCTGGAATATTCAGAAGAGCAGTTGGGGAATGTTGTCCATGGAGTGGGACTCTGCTTTGCCCTTTTT
  CTCTCCGAATGTGTGAAGTCTCTGAGTTTCTCCTCCAGTTGGATCATCAACCAACGCACAGCCATCAGGT
  TCCGAGCAGCTGTTTCCTCCTTTGCCTTTGAGAAGCTCATCCAATTTAAGTCTGTAATACACATCACCTC
  AGGAGAGGCCATCAGCTTCTTCACCGGTGATGTAAACTACCTGTTTGAAGGGGTGTGCTATGGACCCCTA
  GTACTGATCACCTGCGCATCGCTGGTCATCTGCAGCATTTCTTCCTACTTCATTATTGGATACACTGCAT
  TTATTGCCATCTTATGCTATCTCCTGGTTTTCCCACTGGCGGTATTCATGACAAGAATGGCTGTGAAGGC
  TCAGCATCACACATCTGAGGTCAGCGACCAGCGCATCCGTGTGACCAGTGAAGTTCTCACTTGCATTAAG
  CTGATTAAAATGTACACATGGGAGAAACCATTTGCAAAAATCATTGAAGACCTAAGAAGGAAGGAAAGGA
  AACTATTGGAGAAGTGCGGGCTTGTCCAGAGCCTGACAAGTATAACCTTGTTCATCATCCCCACAGTGGC
  CACAGCGGTCTGGGTTCTCATCCACACATCCTTAAAGCTGAAACTCACAGCGTCAATGGCCTTCAGCATG
  CTGGCCTCCTTGAATCTCCTTCGGCTGTCAGTGTTCTTTGTGCCTATTGCAGTCAAAGGTCTCACGAATT
  CCAAGTCTGCAGTGATGAGGTTCAAGAAGTTTTTCCTCCAGGAGAGCCCTGTTTTCTATGTCCAGACATT
  ACAAGACCCCAGCAAAGCTCTGGTCTTTGAGGAGGCCACCTTGTCATGGCAACAGACCTGTCCCGGGATC
  GTCAATGGGGCACTGGAGCTGGAGAGGAACGGGCATGCTTCTGAGGGGATGACCAGGCCTAGAGATGCCC
  TCGGGCCAGAGGAAGAAGGGAACAGCCTGGGCCCAGAGTTGCACAAGATCAACCTGGTGGTGTCCAAGGG
  GATGATGTTAGGGGTCTGCGGCAACACGGGGAGTGGTAAGAGCAGCCTGTTGTCAGCCATCCTGGAGGAG
  ATGCACTTGCTCGAGGGCTCGGTGGGGGTGCAGGGAAGCCTGGCCTATGTCCCCCAGCAGGCCTGGATCG
  TCAGCGGGAACATCAGGGAGAACATCCTCATGGGAGGCGCATATGACAAGGCCCGATACCTCCAGGTGCT
  CCACTGCTGCTCCCTGAATCGGGACCTGGAACTTCTGCCCTTTGGAGACATGACAGAGATTGGAGAGCGG
  GGCCTCAACCTCTCTGGGGGGCAGAAACAGAGGATCAGCCTGGCCCGCGCCGTCTATTCCGACCGTCAGA
  TCTACCTGCTGGACGACCCCCTGTCTGCTGTGGACGCCCACGTGGGGAAGCACATTTTTGAGGAGTGCAT
  TAAGAAGACACTCAGGGGGAAGACGGTCGTCCTGGTGACCCACCAGCTGCAGTACTTAGAATTTTGTGGC
  CAGATCATTTTGTTGGAAAATGGGAAAATCTGTGAAAATGGAACTCACAGTGAGTTAATGCAGAAAAAGG
  GGAAATATGCCCAACTTATCCAGAAGATGCACAAGGAAGCCACTTCGGACATGTTGCAGGACACAGCAAA
  GATAGCAGAGAAGCCAAAGGTAGAAAGTCAGGCTCTGGCCACCTCCCTGGAAGAGTCTCTCAACGGAAAT
  GCTGTGCCGGAGCATCAGCTCACACAGGAGGAGGAGATGGAAGAAGGCTCCTTGAGTTGGAGGGTCTACC
  ACCACTACATCCAGGCAGCTGGAGGTTACATGGTCTCTTGCATAATTTTCTTCTTCGTGGTGCTGATCGT
  CTTCTTAACGATCTTCAGCTTCTGGTGGCTGAGCTACTGGTTGGAGCAGGGCTCGGGGACCAATAGCAGC
  CGAGAGAGCAATGGAACCATGGCAGACCTGGGCAACATTGCAGACAATCCTCAACTGTCCTTCTACCAGC
  TGGTGTACGGGCTCAACGCCCTGCTCCTCATCTGTGTGGGGGTCTGCTCCTCAGGGATTTTCACCAAGGT
  CACGAGGAAGGCATCCACGGCCCTGCACAACAAGCTCTTCAACAAGGTTTTCCGCTGCCCCATGAGTTTC
  TTTGACACCATCCCAATAGGCCGGCTTTTGAACTGCTTCGCAGGGGACTTGGAACAGCTGGACCAGCTCT
  TGCCCATCTTTTCAGAGCAGTTCCTGGTCCTGTCCTTAATGGTGATCGCCGTCCTGTTGATTGTCAGTGT
  GCTGTCTCCATATATCCTGTTAATGGGAGCCATAATCATGGTTATTTGCTTCATTTATTATATGATGTTC
  AAGAAGGCCATCGGTGTGTTCAAGAGACTGGAGAACTATAGCCGGTCTCCTTTATTCTCCCACATCCTCA
  ATTCTCTGCAAGGCCTGAGCTCCATCCATGTCTATGGAAAAACTGAAGACTTCATCAGCCAGTTTAAGAG
  GCTGACTGATGCGCAGAATAACTACCTGCTGTTGTTTCTATCTTCCACACGATGGATGGCATTGAGGCTG
  GAGATCATGACCAACCTTGTGACCTTGGCTGTTGCCCTGTTCGTGGCTTTTGGCATTTCCTCCACCCCCT
  ACTCCTTTAAAGTCATGGCTGTCAACATCGTGCTGCAGCTGGCGTCCAGCTTCCAGGCCACTGCCCGGAT
  TGGCTTGGAGACAGAGGCACAGTTCACGGCTGTAGAGAGGATACTGCAGTACATGAAGATGTGTGTCTCG
  GAAGCTCCTTTACACATGGAAGGCACAAGTTGTCCCCAGGGGTGGCCACAGCATGGGGAAATCATATTTC
  AGGATTATCACATGAAATACAGAGACAACACACCCACCGTGCTTCACGGCATCAACCTGACCATCCGCGG
  CCACGAAGTGGTGGGCATCGTGGGAAGGACGGGCTCTGGGAAGTCCTCCTTGGGCATGGCTCTCTTCCGC
  CTGGTGGAGCCCATGGCAGGCCGGATTCTCATTGACGGCGTGGACATTTGCAGCATCGGCCTGGAGGACT
  TGCGGTCCAAGCTCTCAGTGATCCCTCAAGATCCAGTGCTGCTCTCAGGAACCATCAGATTCAACCTAGA
  TCCCTTTGACCGTCACACTGACCAGCAGATCTGGGATGCCTTGGAGAGGACATTCCTGACCAAGGCCATC
  ATCCTTATCGATGAAGCCACAGCCTCCATTGACATGGAGACAGACACCCTGATCCAGCGCACAATCCGTG
  AAGCCTTCCAGGGCTGCACCGTGCTCGTCATTGCCCACCGTGTCACCACTGTGCTGAACTGTGACCACAT
  CCTGGTTATGGGCAATGGGAAGGTGGTAGAATTTGATCGGCCGGAGGTACTGCGGAAGAAGCCTGGGTCA
  TTGTTCGCAGCCCTCATGGCCACAGCCACTTCTTCACTGAGA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
  Protein Sequence

  >RC217370 representing NM_145186
  Red=Cloning site Green=Tags(s)
  
  MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPPWGKYDAALRT
  MIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE
  VSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLGPILIIPKILEYSEEQLGNVVHGVGLCFALF
  LSECVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPL
  VLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIK
  LIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM
  LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGI
  VNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEE
  MHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGER
  GLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCG
  QIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGN
  AVPEHQLTQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS
  RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSF
  FDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMF
  KKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRL
  EIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVS
  EAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFR
  LVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAI
  ILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGS
  LFAALMATATSSLR
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_145186
• ORF Size: 4032 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_145186.1, NM_145186.2, NP_660187.1
• RefSeq Size: 4462
• RefSeq ORF: 4035
• Locus ID: 85320
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: ABC transporters
• MW: 150.1 kDa
• Gene Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]