SLC39A14 (NM_015359) Human Tagged ORF Clone

CAT#: RC217966

SLC39A14 (Myc-DDK-tagged)-Human solute carrier family 39 (zinc transporter), member 14 (SLC39A14), transcript variant 2

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: SLC39A14
• Synonyms: cig19; HCIN; HMNDYT2; LZT-Hs4; NET34; ZIP14
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RC217966 representing NM_015359
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGAAGCTGCTGCTGCTGCACCCGGCCTTCCAGAGCTGCCTCCTGCTGACCCTGCTTGGCTTATGGAGAA
  CCACCCCTGAGGCTCACGCTTCATCCCTGGGTGCACCAGCTATCAGCGCTGCCTCCTTCCTGCAGGATCT
  AATACATCGGTATGGCGAGGGTGACAGCCTCACTCTGCAGCAGCTGAAGGCCCTACTCAACCACCTGGAT
  GTGGGAGTGGGCCGGGGTAATGTCACCCAGCACGTGCAAGGACACAGGAACCTCTCCACGTGCTTTAGTT
  CTGGAGACCTCTTCACTGCCCACAATTTCAGCGAGCAGTCGCGGATTGGGAGCAGCGAGCTCCAGGAGTT
  CTGCCCCACCATCCTCCAGCAGCTGGATTCCCGGGCCTGCACCTCGGAGAACCAGGAAAACGAGGAGAAT
  GAGCAGACGGAGGAGGGGCGGCCAAGCGCTGTTGAAGTGTGGGGCTTTGGTTTTCTCAGTGTCTCACTGA
  TTAACCTGGCCTCTCTCCTGGGAGTCCTCGTCCTGCCCTGCACAGAGAAAGCGTTTTTCAGCCGTGTGCT
  CACTTACTTCATCGCCCTGTCCATTGGAACGCTGCTGTCTAACGCGCTATTCCAGCTCATCCCAGAGGCA
  TTTGGTTTCAACCCTCTGGAAGATTATTATGTCTCCAAGTCTGCAGTGGTGTTTGGGGGCTTTTATCTTT
  TCTTTTTCACAGAGAAGATCTTGAAGATTCTTCTTAAGCAGAAAAATGAGCATCATCATGGACACAGCCA
  TTATGCCTCTGAGTCGCTTCCCTCCAAGAAGGACCAGGAGGAGGGGGTGATGGAGAAGCTGCAGAACGGG
  GACCTGGACCACATGATTCCTCAGCACTGCAGCAGTGAGCTGGACGGCAAGGCGCCCATGGTGGACGAGA
  AGGTCATTGTGGGCTCGCTCTCTGTGCAGGACCTGCAGGCTTCCCAGAGTGCTTGCTACTGGCTGAAAGG
  TGTCCGCTACTCTGATATCGGCACTCTGGCCTGGATGATCACTCTGAGCGACGGCCTCCATAATTTCATC
  GATGGCCTGGCCATCGGTGCTTCCTTCACTGTGTCAGTTTTCCAAGGCATCAGCACCTCGGTGGCCATCC
  TCTGTGAGGAGTTCCCACATGAGCTAGGAGACTTTGTCATCCTGCTCAACGCTGGGATGAGCATCCAACA
  AGCTCTCTTCTTCAACTTCCTTTCTGCCTGCTGCTGCTACCTGGGTCTGGCCTTTGGCATCCTGGCCGGC
  AGCCACTTCTCTGCCAACTGGATTTTTGCGCTAGCTGGAGGAATGTTCTTGTATATTTCTCTGGCTGATA
  TGTTCCCTGAGATGAATGAGGTCTGTCAAGAGGATGAAAGGAAGGGCAGCATCTTGATTCCATTTATCAT
  CCAGAACCTGGGCCTCCTGACTGGATTCACCATCATGGTGGTCCTCACCATGTATTCAGGACAGATCCAG
  ATTGGG
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
  Protein Sequence

  >RC217966 representing NM_015359
  Red=Cloning site Green=Tags(s)
  
  MKLLLLHPAFQSCLLLTLLGLWRTTPEAHASSLGAPAISAASFLQDLIHRYGEGDSLTLQQLKALLNHLD
  VGVGRGNVTQHVQGHRNLSTCFSSGDLFTAHNFSEQSRIGSSELQEFCPTILQQLDSRACTSENQENEEN
  EQTEEGRPSAVEVWGFGFLSVSLINLASLLGVLVLPCTEKAFFSRVLTYFIALSIGTLLSNALFQLIPEA
  FGFNPLEDYYVSKSAVVFGGFYLFFFTEKILKILLKQKNEHHHGHSHYASESLPSKKDQEEGVMEKLQNG
  DLDHMIPQHCSSELDGKAPMVDEKVIVGSLSVQDLQASQSACYWLKGVRYSDIGTLAWMITLSDGLHNFI
  DGLAIGASFTVSVFQGISTSVAILCEEFPHELGDFVILLNAGMSIQQALFFNFLSACCCYLGLAFGILAG
  SHFSANWIFALAGGMFLYISLADMFPEMNEVCQEDERKGSILIPFIIQNLGLLTGFTIMVVLTMYSGQIQ
  IG
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_015359
• ORF Size: 1476 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_015359.1, NM_015359.2, NM_015359.3, NM_015359.4, NP_056174.1, NP_056174.2
• RefSeq Size: 4627
• RefSeq ORF: 1479
• Locus ID: 23516
• Protein Families: Transmembrane
• MW: 53.9 kDa
• Gene Summary: This gene encodes a member of the the SLC39A family of divalent metal transporters that mediates the cellular uptake of manganese, zinc, iron, and cadmium. The encoded protein contains eight transmembrane domains, a histidine-rich motif, and a metalloprotease motif, and is expressed on the plasma membrane and the endocytic vesicle membrane. It is an important transporter of nontransferrin-bound iron and a critical regulator of manganese homeostasis. Naturally occurring mutations in this gene are associated with neurodegeneration with brain iron accumulation and early-onset parkinsonism-dystonia with hypermanganesemia. [provided by RefSeq, May 2017]