SETD7 (NM_030648) Human Tagged ORF Clone
CAT#: RC219244L4
- LentiORF®
Lenti ORF clone of Human SET domain containing (lysine methyltransferase) 7 (SETD7), mGFP tagged
"NM_030648" in other vectors (6)
Product Images
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Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | mGFP |
Symbol | SETD7 |
Synonyms | KMT7; SET7; SET7/9; SET9 |
Vector | pLenti-C-mGFP-P2A-Puro |
E. coli Selection | Chloramphenicol (34 ug/mL) |
Mammalian Cell Selection | Puromycin |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC219244).
|
Restriction Sites | SgfI-MluI Cloning Scheme for this gene |
ACCN | NM_030648 |
ORF Size | 1098 bp |
OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_030648.2, NP_085151.1 |
RefSeq Size | 7012 |
RefSeq ORF | 1101 |
Locus ID | 80854 |
Domains | SET, MORN |
Protein Families | Druggable Genome |
Protein Pathways | Lysine degradation |
MW | 40.5 kDa |
Gene Summary | Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. [UniProtKB/Swiss-Prot Function] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
SC310486 | SETD7 (untagged)-Human SET domain containing (lysine methyltransferase) 7 (SETD7) |
USD 760.00 |
|
RC219244 | SETD7 (Myc-DDK-tagged)-Human SET domain containing (lysine methyltransferase) 7 (SETD7) |
USD 420.00 |
|
RG219244 | SETD7 (GFP-tagged) - Human SET domain containing (lysine methyltransferase) 7 (SETD7) |
USD 460.00 |
|
RC219244L1 | Lenti ORF clone of Human SET domain containing (lysine methyltransferase) 7 (SETD7), Myc-DDK-tagged |
USD 620.00 |
|
RC219244L2 | Lenti ORF clone of Human SET domain containing (lysine methyltransferase) 7 (SETD7), mGFP tagged |
USD 620.00 |
|
RC219244L3 | Lenti ORF clone of Human SET domain containing (lysine methyltransferase) 7 (SETD7), Myc-DDK-tagged |
USD 620.00 |
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