TIAM1 (NM_003253) Human Tagged ORF Clone
CAT#: RC220233L3
- LentiORF®
Lenti ORF clone of Human T-cell lymphoma invasion and metastasis 1 (TIAM1), Myc-DDK-tagged
"NM_003253" in other vectors (6)
Product Images
Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | Myc-DDK |
Symbol | TIAM1 |
Synonyms | TIAM-1 |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
E. coli Selection | Chloramphenicol (34 ug/mL) |
Mammalian Cell Selection | Puromycin |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC220233).
|
Restriction Sites | SgfI-RsrII Cloning Scheme for this gene |
ACCN | NM_003253 |
ORF Size | 4773 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_003253.1 |
RefSeq Size | 5521 |
RefSeq ORF | 4776 |
Locus ID | 7074 |
Domains | RhoGEF, PDZ, PH, RBD |
Protein Families | Druggable Genome |
Protein Pathways | Chemokine signaling pathway, Regulation of actin cytoskeleton |
MW | 177.3 kDa |
Gene Summary | This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain. [provided by RefSeq, Jul 2017] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
SC309903 | TIAM1 (untagged)-Human T-cell lymphoma invasion and metastasis 1 (TIAM1) |
USD 1,100.00 |
|
RC220233 | TIAM1 (Myc-DDK-tagged)-Human T-cell lymphoma invasion and metastasis 1 (TIAM1) |
USD 600.00 |
|
RG220233 | TIAM1 (GFP-tagged) - Human T-cell lymphoma invasion and metastasis 1 (TIAM1) |
USD 660.00 |
|
RC220233L1 | Lenti ORF clone of Human T-cell lymphoma invasion and metastasis 1 (TIAM1), Myc-DDK-tagged |
USD 800.00 |
|
RC220233L2 | Lenti ORF clone of Human T-cell lymphoma invasion and metastasis 1 (TIAM1), mGFP tagged |
USD 800.00 |
|
RC220233L4 | Lenti ORF clone of Human T-cell lymphoma invasion and metastasis 1 (TIAM1), mGFP tagged |
USD 800.00 |
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