Cytochrome P450 26B (CYP26B1) (NM_019885) Human Tagged ORF Clone

CAT#: RC221075

CYP26B1 (Myc-DDK-tagged)-Human cytochrome P450, family 26, subfamily B, polypeptide 1 (CYP26B1)

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: CYP26B1
• Synonyms: CYP26A2; P450RAI-2; P450RAI2; RHFCA
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RC221075 representing NM_019885
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGCTCTTTGAGGGCTTGGATCTGGTGTCGGCGCTGGCCACCCTCGCCGCGTGCCTGGTGTCCGTGACGC
  TGCTGCTGGCCGTGTCGCAGCAGCTGTGGCAGCTGCGCTGGGCCGCCACTCGCGACAAGAGCTGCAAGCT
  GCCCATCCCCAAGGGATCCATGGGCTTCCCGCTCATCGGAGAGACCGGCCACTGGCTGCTGCAGGGTTCT
  GGCTTCCAGTCGTCGCGGAGGGAGAAGTATGGCAACGTGTTCAAGACGCATTTGTTGGGGCGGCCGCTGA
  TACGCGTGACCGGCGCGGAGAACGTGCGCAAGATCCTCATGGGCGAGCACCACCTCGTGAGCACCGAGTG
  GCCTCGCAGCACCCGCATGTTGCTGGGCCCCAACACGGTGTCCAATTCCATTGGCGACATCCACCGCAAC
  AAGCGCAAGGTCTTCTCCAAGATCTTCAGCCACGAGGCCCTGGAGAGTTACCTGCCCAAGATCCAGCTGG
  TGATCCAGGACACACTGCGCGCCTGGAGCAGCCACCCCGAGGCCATCAACGTGTACCAGGAGGCGCAGAA
  GCTGACCTTCCGCATGGCCATCCGGGTGCTGCTGGGCTTCAGCATCCCTGAGGAGGACCTTGGGCACCTC
  TTTGAGGTCTACCAGCAGTTTGTGGACAATGTCTTCTCCCTGCCTGTCGACCTGCCCTTCAGTGGCTACC
  GGCGGGGCATTCAGGCTCGGCAGATCCTGCAGAAGGGGCTGGAGAAGGCCATCCGGGAGAAGCTGCAGTG
  CACACAGGGCAAGGACTACTTGGACGCCCTGGACCTCCTCATTGAGAGCAGCAAGGAGCACGGGAAGGAG
  ATGACCATGCAGGAGCTGAAGGACGGGACCCTGGAGCTGATCTTTGCGGCCTATGCCACCACGGCCAGCG
  CCAGCACCTCACTCATCATGCAGCTGCTGAAGCACCCCACTGTGCTGGAGAAGCTGCGGGATGAGCTGCG
  GGCTCATGGCATCCTGCACAGTGGCGGCTGCCCCTGCGAGGGCACACTGCGCCTGGACACGCTCAGTGGG
  CTGCGCTACCTGGACTGCGTCATCAAGGAGGTCATGCGCCTGTTCACGCCCATTTCCGGCGGCTACCGCA
  CTGTGCTGCAGACCTTCGAGCTTGATGGTTTCCAGATCCCCAAAGGCTGGAGTGTCATGTATAGCATCCG
  GGACACCCATGACACAGCGCCCGTGTTCAAAGACGTGAACGTGTTCGACCCCGATCGCTTCAGCCAGGCG
  CGGAGCGAGGACAAGGATGGCCGCTTCCATTACCTCCCGTTCGGTGGCGGTGTCCGGACCTGCCTGGGCA
  AGCACCTGGCCAAGCTGTTCCTGAAGGTGCTGGCGGTGGAGCTGGCTAGCACCAGCCGCTTTGAGCTGGC
  CACACGGACCTTCCCCCGCATCACCTTGGTCCCCGTCCTGCACCCCGTGGATGGCCTCAGCGTCAAGTTC
  TTTGGCCTGGACTCCAACCAGAACGAGATCCTGCCGGAGACGGAGGCCATGCTGAGCGCCACAGTC
  
  AGCGGACCGACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCC
  TGGATTACAAGGATGACGACGATAAGGTTTAA
  Protein Sequence

  >RC221075 representing NM_019885
  Red=Cloning site Green=Tags(s)
  
  MLFEGLDLVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGS
  GFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPRSTRMLLGPNTVSNSIGDIHRN
  KRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIPEEDLGHL
  FEVYQQFVDNVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYLDALDLLIESSKEHGKE
  MTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSG
  LRYLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQA
  RSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKF
  FGLDSNQNEILPETEAMLSATV
  
  SGPTRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Restriction Sites: SgfI-RsrII Cloning Scheme for this gene Plasmid Map
• ACCN: NM_019885
• ORF Size: 1536 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_019885.1, NM_019885.2, NM_019885.3, NP_063938.1
• RefSeq Size: 4567
• RefSeq ORF: 1539
• Locus ID: 56603
• Protein Families: Druggable Genome, P450
• Protein Pathways: Retinol metabolism
• MW: 58 kDa
• Gene Summary: This gene encodes a member of the cytochrome P450 superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein is localized to the endoplasmic reticulum, and functions as a critical regulator of all-trans retinoic acid levels by the specific inactivation of all-trans retinoic acid to hydroxylated forms. Mutations in this gene are associated with radiohumeral fusions and other skeletal and craniofacial anomalies, and increased levels of the encoded protein are associated with atherosclerotic lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]