GALR2 (NM_003857) Human Tagged ORF Clone
CAT#: RC222436L3
- LentiORF®
Lenti ORF clone of Human galanin receptor 2 (GALR2), Myc-DDK-tagged
"NM_003857" in other vectors (6)
Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | Myc-DDK |
Symbol | GALR2 |
Synonyms | GAL2-R; GALNR2; GALR-2 |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
E. coli Selection | Chloramphenicol (34 ug/mL) |
Mammalian Cell Selection | Puromycin |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC222436).
|
Restriction Sites | SgfI-MluI Cloning Scheme for this gene |
ACCN | NM_003857 |
ORF Size | 1161 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_003857.2 |
RefSeq Size | 1309 bp |
RefSeq ORF | 1164 bp |
Locus ID | 8811 |
UniProt ID | O43603 |
Cytogenetics | 17q25.1 |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Neuroactive ligand-receptor interaction |
MW | 41.5 kDa |
Gene Summary | Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
SC303390 | GALR2 (untagged)-Human galanin receptor 2 (GALR2) |
USD 760.00 |
|
RC222436 | GALR2 (Myc-DDK-tagged)-Human galanin receptor 2 (GALR2) |
USD 420.00 |
|
RG222436 | GALR2 (GFP-tagged) - Human galanin receptor 2 (GALR2) |
USD 460.00 |
|
RC222436L1 | Lenti ORF clone of Human galanin receptor 2 (GALR2), Myc-DDK-tagged |
USD 620.00 |
|
RC222436L2 | Lenti ORF clone of Human galanin receptor 2 (GALR2), mGFP tagged |
USD 620.00 |
|
RC222436L4 | Lenti ORF clone of Human galanin receptor 2 (GALR2), mGFP tagged |
USD 620.00 |
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