MPP5 (NM_022474) Human Tagged ORF Clone

CAT#: RC224752L2

Lenti ORF clone of Human membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) (MPP5), mGFP tagged

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: mGFP
• Symbol: MPP5
• Synonyms: PALS1
• Vector: pLenti-C-mGFP
• E. coli Selection: Chloramphenicol (34 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC224752).
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene
• ACCN: NM_022474
• ORF Size: 2025 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_022474.2, NP_071919.2
• RefSeq Size: 5608
• RefSeq ORF: 2028
• Locus ID: 64398
• Domains: SH3, PDZ, L27, Guanylate_kin, GuKc
• Protein Families: Druggable Genome
• Protein Pathways: Tight junction
• MW: 77.3 kDa
• Gene Summary: This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]