Prickle (PRICKLE1) (NM_001144883) Human Tagged ORF Clone

CAT#: RC227340L4

Lenti-ORF clone of PRICKLE1 (mGFP-tagged)-Human prickle homolog 1 (Drosophila) (PRICKLE1), transcript variant 4

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: mGFP
• Symbol: PRICKLE1
• Synonyms: EPM1B; RILP
• Vector: pLenti-C-mGFP-P2A-Puro
• E. coli Selection: Chloramphenicol (34 ug/mL)
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC227340).
• Restriction Sites: SgfI-RsrII Cloning Scheme for this gene
• ACCN: NM_001144883
• ORF Size: 2493 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001144883.1, NP_001138355.1
• RefSeq ORF: 2496
• Locus ID: 144165
• Protein Families: Druggable Genome
• Protein Pathways: Wnt signaling pathway
• MW: 94.1 kDa
• Gene Summary: This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2009]