TXNRD3 (NM_052883) Human Tagged ORF Clone
CAT#: RC230387L4
- LentiORF®
Lenti-ORF, TXNRD3 (mGFP-tagged) - Human thioredoxin reductase 3 (TXNRD3), transcript variant 1, (Note: selenocystein protein, Internal stop codon present. See Summary below)
"NM_052883" in other vectors (4)
Product Images
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Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | mGFP |
Symbol | TXNRD3 |
Synonyms | TGR; TR2; TR2IT1; TRXR3; TXNRD3IT1; TXNRD3NB; TXNRD3NT1 |
Vector | pLenti-C-mGFP-P2A-Puro |
E. coli Selection | Chloramphenicol (34 ug/mL) |
Mammalian Cell Selection | Puromycin |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC230387).
|
Restriction Sites | SgfI-MluI Cloning Scheme for this gene |
ACCN | NM_052883 |
OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info The expression of this clone is not guaranteed due to the nature of selenoproteins. |
OTI Annotation | This clone encodes a selenoprotein containing the rare amino acid selenocysteine (Sec). Sec is encoded by UGA codon, which normally signals translational termination. Expression of this clone is not guaranteed due to the nature of selenoproteins. |
Reference Data | |
RefSeq | NM_052883.1, NP_443115.1 |
RefSeq ORF | 1932 |
Locus ID | 114112 |
Gene Summary | The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes the third TrxR, which unlike the other two isozymes, contains an additional N-terminal glutaredoxin (Grx) domain, and shows highest expression in testis. The Grx domain allows this isozyme to participate in both Trx and glutathione systems. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. Experimental evidence suggests the use of a non-AUG (CUG) codon as a translation initiation codon (PMID:20018845). [provided by RefSeq, Aug 2017] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
SC329025 | TXNRD3 (untagged)-Human thioredoxin reductase 3 (TXNRD3) transcript variant 1 (10ug), (Note: selenocysteine protein, Internal stop codon present. see reference data summary below) |
USD 1,090.00 |
|
RC230387 | TXNRD3 (Myc-DDK-tagged)-Human thioredoxin reductase 3 (TXNRD3), transcript variant 1, (Note, selenocysteine protein, internal stop codon, see reference data summary) |
USD 480.00 |
|
RG230387 | TXNRD3 (GFP-tagged) - Human thioredoxin reductase 3 (TXNRD3), transcript variant 1, (10ug), (Note: selenocysteine protein, Internal stop codon present. see reference data summary below) |
USD 530.00 |
|
RC230387L3 | Lenti-ORF, TXNRD3 (Myc-DDK-tagged)-Human thioredoxin reductase 3 (TXNRD3), transcript variant 1, (Note, selenocystein protein, internal stop codon, see summary) |
USD 680.00 |
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