ALDH1L1 (NM_001270365) Human Tagged ORF Clone

CAT#: RC233141

ALDH1L1 (Myc-DDK tagged) - Homo sapiens aldehyde dehydrogenase 1 family, member L1 (ALDH1L1), transcript variant 3

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: ALDH1L1
• Synonyms: 10-fTHF; 10-FTHFDH; FDH; FTHFD
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RC233141 representing NM_001270365
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGAAGATTGCAGTGATTGGACAGAGCCTGTTTGGCCAGGAAGTTTACTGCCACCTGAGGAAGGAGGGCC
  ACGAAGTGGTGGGTGTGTTCACTGTTCCAGACAAGGATGGAAAGGCCGACCCCCTGGGTCTGGAAGCTGA
  GAAGGATGGAGTGCCGGTATTCAAGTACTCCCGGTGGCGTGCAAAAGGACAGGCTTTGCCTGATGTGGTG
  GCAAAATACCAGGCTTTGGGGGCCGAGCTCAACGTCCTGCCCTTCTGCAGCCAATTCATCCCCATGGAGA
  TAATCAGTGCCCCCCGGCATGGCTCCATCATCTATCACCCGTCACTGCTCCCTAGGCACCGAGGGGCCTC
  GGCCATTCACAACTGGATCCGCGGGAACGACAAGGTGCCGGGAGCCTGGACAGAGGCCTGTGAACAGAAA
  CTGACATTTTTCAACTCAACGCTGAACACTTCAGGCCTGGTGCCCGAGGGAGACGCTTTGCCCATCCCAG
  GAGCCCATCGGCCAGGGGTGGTCACCAAAGCAGGACTCATCCTCTTTGGGAATGATGACAAAATGCTGCT
  GGTGAAGAATATTCAGCTGGAGGATGGCAAAATGATCCTGGCCTCGAACTTCTTTAAGGGGGCAGCCAGC
  AGTGTCCTTGAGCTGACAGAGGCAGAGCTGGTTACTGCGGAGGCTGTGCGGAGTGTTTGGCAGCGGATCC
  TCCCCAAAGTCCTGGAGGTTGAAGACTCCACTGATTTCTTCAAGTCAGGGGCCGCGTCTGTGGACGTTGT
  GAGGCTGGTGGAGGAAGTGAAGGAGCTGTGTGATGGCCTGGAGTTAGAAAATGAAGATGTGTACATGGCA
  TCCACCTTTGGGGACTTCATCCAGCTGTTAGTGAGGAAGCTGCGAGGGGACGATGAGGAGGGCGAGTGCA
  GCATTGACTACGTGGAAATGGCAGTGAACAAGCGCACTGTCCGCATGCCCCACCAGCTCTTCATTGGGGG
  GGAGTTCGTGGATGCCGAGGGCGCCAAGACCTCTGAGACCATCAATCCCACCGATGGAAGTGTCATCTGC
  CAGGTATCCCTGGCCCAAGTCACCGACGTCGACAAGGCAGTGGCCGCAGCCAAGGATGCCTTTGAGAATG
  GACGGTGGGGGAAGATCAGTGCGCGGGACCGGGGCCGGCTGATGTACAGGTTGGCAGATCTCATGGAGCA
  GCACCAGGAGGAGCTGGCCACCATTGAGGCCCTGGATGCGGGTGCCGTCTACACGCTGGCCCTGAAGACC
  CACGTGGGCATGTCCATCCAGACCTTCCGCTACTTTGCTGGCTGGTGTGACAAGATCCAGGGCTCCACCA
  TCCCCATCAACCAGGCCAGACCCAACCGCAACCTGACCTTGACCAGGAAGGAGCCTGTTGGGGTTTGTGG
  CATCATCATCCCCTGGAACTATCCCCTGATGATGCTGTCCTGGAAGACAGCTGCCTGCCTGGCTGCCGGG
  AACACAGTGGTGATCAAGCCTGCTCAGGTGACCCCACTCACAGCCTTGAAGTTTGCAGAGCTGACATTAA
  AGGCCGGCATTCCCAAAGGTGTGGTTAACGTCCTCCCAGGATCTGGCTCCCTGGTCGGCCAGAGACTCTC
  AGACCATCCTGATGTGAGGAAAATCGGGTTCACAGGCTCCACAGAGGTGGGCAAGCACATCATGAAAAGC
  TGTGCCATAAGTAACGTGAAGAAGGTGTCCCTGGAACTGGGCGGGAAGTCACCCCTCATCATCTTTGCTG
  ACTGTGACCTCAACAAGGCTGTGCAGATGGGGATGAGTTCTGTTTTCTTCAACAAAGGAGAGAATTGCAT
  TGCAGCAGGCCGACTCTTTGTGGAGGACTCCATTCATGATGAGTTCGTGCGGAGAGTGGTAGAAGAGGTG
  CGGAAGATGAAGGTGGGCAACCCGCTGGACAGGGACACCGACCACGGGCCGCAGAATCACCATGCCCACC
  TTGTGAAGCTGATGGAGTACTGCCAGCATGGCGTGAAGGAAGGGGCCACACTGGTCTGCGGCGGGAATCA
  GGTCCCTCGGCCAGGGTTCTTCTTTGAGCCAACTGTTTTCACAGACGTGGAAGACCACATGTTCATAGCC
  AAGGAGGAGTCCTTCGGGCCTGTCATGATCATCTCTCGGTTTGCTGATGGGGACTTGGATGCCGTGCTGT
  CTCGGGCCAATGCCACGGAATTTGGCCTGGCTTCTGGTGTCTTCACCAGGGACATCAACAAGGCCCTGTA
  TGTCAGTGACAAGCTCCAGGCAGGCACTGTGTTTGTCAACACGTACAACAAGACCGACGTGGCCGCTCCC
  TTCGGAGGATTCAAACAGTCTGGATTTGGCAAAGATCTAGGAGAGGCGGCTCTGAACGAGTACCTGCGGG
  TCAAGACAGTGACCTTCGAATAC
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
  Protein Sequence

  >RC233141 representing NM_001270365
  Red=Cloning site Green=Tags(s)
  
  MKIAVIGQSLFGQEVYCHLRKEGHEVVGVFTVPDKDGKADPLGLEAEKDGVPVFKYSRWRAKGQALPDVV
  AKYQALGAELNVLPFCSQFIPMEIISAPRHGSIIYHPSLLPRHRGASAIHNWIRGNDKVPGAWTEACEQK
  LTFFNSTLNTSGLVPEGDALPIPGAHRPGVVTKAGLILFGNDDKMLLVKNIQLEDGKMILASNFFKGAAS
  SVLELTEAELVTAEAVRSVWQRILPKVLEVEDSTDFFKSGAASVDVVRLVEEVKELCDGLELENEDVYMA
  STFGDFIQLLVRKLRGDDEEGECSIDYVEMAVNKRTVRMPHQLFIGGEFVDAEGAKTSETINPTDGSVIC
  QVSLAQVTDVDKAVAAAKDAFENGRWGKISARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKT
  HVGMSIQTFRYFAGWCDKIQGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAG
  NTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKS
  CAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEV
  RKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHMFIA
  KEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFVNTYNKTDVAAP
  FGGFKQSGFGKDLGEAALNEYLRVKTVTFEY
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_001270365
• ORF Size: 2403 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001270365.1, NP_001257294.1
• RefSeq Size: 3003
• RefSeq ORF: 2406
• Locus ID: 10840
• Protein Families: Druggable Genome
• Protein Pathways: One carbon pool by folate
• MW: 88.1 kDa
• Gene Summary: The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]