RGS6 (NM_001204423) Human Tagged ORF Clone

CAT#: RC234091

RGS6 (Myc-DDK tagged) - Homo sapiens regulator of G-protein signaling 6 (RGS6), transcript variant 9

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: RGS6
• Synonyms: GAP; HA117; S914
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RC234091 representing NM_001204423
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGCAAGATGACAAGACAGGGGGTGTGCCCATCAGAACAGTCAAGAGCTTTCTCTCCAAAATCCCCAGTG
  TCGTCACAGGTACTGACATTGTGCAGTGGCTTATGAAGAACCTTTCCATTGAGGACCCAGTTGAAGCAAT
  ACACTTGGGGAGCCTTATCGCTGCCCAGGGCTACATCTTTCCAATCTCAGACCATGTTCTCACCATGAAG
  GATGATGGCACCTTTTATCGTTTCCAGGCTCCGTACTTCTGGCCTTCGAACTGCTGGGAACCTGAAAACA
  CTGACTATGCCATCTATCTCTGTAAGAGGACAATGCAAAATAAAGCAAGGCTGGAACTGGCAGATTATGA
  AGCAGAAAACTTAGCAAGACTCCAGAGGGCCTTTGCGAGGAAGTGGGAATTCATCTTTATGCAAGCAGAA
  GCACAAGTAAAGATTGACCGGAAAAAAGACAAGACAGAAAGGAAAATTTTGGATAGTCAAGAACGAGCCT
  TTTGGGATGTCCACAGGCCTGTGCCAGGCTGTGTGAACACAACAGAAATGGATATCCGAAAATGTCGACG
  TTTGAAGAATCCACAAAAGGTTAAAAAGTCCGTGTATGGCGTGACTGAAGAGTCCCAGGCACAGAGCCCG
  GTGCATGTACTCAGCCAACCAATCAGGAAAACAACAAAAGAGGACATCCGGAAACAGATAACATTTTTGA
  ACGCACAGATCGACAGACATTGTTTGAAAATGTCCAAAGTGGCTGAAAGTTTAATTGCCTACACGGAACA
  ATATGTGGAATATGACCCTTTGATAACACCAGCTGAGCCATCCAACCCTTGGATCAGCGATGACGTTGCT
  TTGTGGGACATAGAGATGAGCAAAGAGCCCAGCCAACAGCGAGTAAAAAGATGGGGCTTCTCTTTCGATG
  AGATATTGAAGGACCAGGTGGGGCGGGACCAGTTTCTACGATTCCTGGAGTCCGAATTCAGTTCAGAAAA
  CCTCAGGTTCTGGCTGGCTGTCCAAGATCTTAAGAAACAACCCCTACAGGATGTGGCCAAGAGGGTAGAA
  GAAATCTGGCAAGAGTTTCTGGCTCCAGGGGCTCCAAGTGCAATCAACCTGGATTCTCACAGCTATGAGA
  TAACCAGTCAAAATGTCAAAGATGGAGGGAGATATACATTTGAAGACGCCCAGGAGCACATCTACAAGCT
  GATGAAGAGTGACAGCTATGCCCGCTTCCTCCGGTCAAATGCTTACCAGGATTTGCTGCTGGCCAAGAAG
  AAGGGAAAGTCGCTGGCGGGCAAGCGCCTCACGGGCCTGATGCAGTCCTCC
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
  Protein Sequence

  >RC234091 representing NM_001204423
  Red=Cloning site Green=Tags(s)
  
  MQDDKTGGVPIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVLTMK
  DDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAE
  AQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQAQSP
  VHVLSQPIRKTTKEDIRKQITFLNAQIDRHCLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVA
  LWDIEMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVE
  EIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDLLLAKK
  KGKSLAGKRLTGLMQSS
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_001204423
• ORF Size: 1311 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001204423.1, NP_001191352.1
• RefSeq Size: 5546
• RefSeq ORF: 1314
• Locus ID: 9628
• Protein Families: Druggable Genome
• MW: 51.1 kDa
• Gene Summary: This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known. [provided by RefSeq, Mar 2011]