ERBIN (NM_001253697) Human Tagged ORF Clone

CAT#: RC235298

ERBB2IP (Myc-DDK tagged) - Homo sapiens erbb2 interacting protein (ERBB2IP), transcript variant 1

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: ERBIN
• Synonyms: ERBB2IP; HEL-S-78; LAP2
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RC235298 representing NM_001253697
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGACTACAAAACGAAGTTTGTTTGTGCGGTTGGTACCATGTCGCTGTCTACGAGGGGAAGAGGAGACTG
  TCACTACTCTTGATTATTCTCATTGCAGCTTAGAACAAGTTCCGAAAGAGATTTTTACTTTTGAAAAAAC
  CTTGGAGGAACTCTATTTAGATGCTAATCAGATTGAAGAGCTTCCAAAGCAACTTTTTAACTGTCAGTCT
  TTACACAAACTGAGTTTGCCAGACAATGATTTAACAACGTTACCAGCATCCATTGCAAACCTTATTAATC
  TCAGGGAACTGGATGTCAGCAAGAATGGAATACAGGAGTTTCCAGAAAATATAAAAAATTGTAAAGTTTT
  GACAATTGTGGAGGCCAGTGTAAACCCTATTTCCAAGCTCCCTGATGGATTTTCTCAGCTGTTAAACCTA
  ACCCAGTTGTATCTGAATGATGCTTTTCTTGAGTTCTTGCCAGCAAATTTTGGCAGATTAACTAAACTCC
  AAATATTAGAGCTTAGAGAAAACCAGTTAAAAATGTTGCCTAAAACTATGAATAGACTGACCCAGCTGGA
  AAGACTGGATTTGGGAAGTAACGAATTCACGGAAGTGCCTGAAGTACTTGAGCAACTAAGTGGATTGAAA
  GAGTTTTGGATGGATGCTAATAGACTGACTTTTATTCCAGGGTTTATTGGTAGTTTGAAACAGCTCACAT
  ATTTGGATGTTTCTAAAAATAATATTGAAATGGTTGAAGAAGGAATTTCAACATGTGAAAACCTTCAAGA
  CCTCCTATTATCAAGCAATTCACTTCAGCAGCTTCCTGAGACTATTGGTTCGTTGAAGAATATAACAACG
  CTTAAAATAGATGAAAACCAGTTAATGTATCTGCCAGACTCTATAGGAGGGTTAATATCAGTAGAAGAAC
  TGGATTGTAGTTTCAATGAAGTTGAAGCTTTGCCTTCATCTATTGGGCAGCTTACTAACTTAAGAACTTT
  TGCTGCTGATCATAATTACTTACAGCAGTTGCCCCCAGAGATTGGAAGCTGGAAAAATATAACTGTGCTG
  TTTCTCCATTCCAATAAACTTGAGACACTTCCAGAGGAAATGGGTGATATGCAAAAATTAAAAGTCATTA
  ATTTAAGTGATAATAGATTAAAGAATTTACCCTTTAGCTTTACAAAGCTACAGCAATTGACAGCTATGTG
  GCTCTCAGATAATCAGTCCAAACCCCTGATACCTCTTCAAAAAGAAACTGATTCAGAGACCCAGAAAATG
  GTGCTTACCAACTACATGTTCCCTCAACAGCCAAGGACTGAGGATGTTATGTTTATATCAGATAATGAAA
  GTTTTAACCCTTCATTGTGGGAGGAACAGAGGAAACAGCGGGCTCAAGTTGCATTTGAATGTGATGAAGA
  CAAAGATGAAAGGGAGGCACCTCCCAGGGAGGGAAATTTAAAAAGATATCCAACACCATACCCAGATGAG
  CTTAAGAATATGGTCAAAACTGTTCAAACCATTGTACATAGATTAAAAGATGAAGAGACCAATGAAGACT
  CAGGAAGAGATTTGAAACCACATGAAGATCAACAAGATATAAATAAAGATGTGGGTGTGAAGACCTCAGA
  AAGTACTACTACAGTAAAAAGCAAAGTTGATGAAAGAGAAAAATATATGATAGGAAACTCTGTACAGAAG
  ATCAGTGAACCTGAAGCTGAGATTAGTCCTGGGAGTTTACCAGTGACTGCAAATATGAAAGCCTCTGAGA
  ACTTGAAGCATATTGTTAACCATGATGATGTTTTTGAGGAATCTGAAGAACTTTCTTCTGATGAAGAGAT
  GAAAATGGCGGAGATGCGACCACCATTAATTGAAACCTCTATTAACCAGCCAAAAGTCGTAGCACTTAGT
  AATAACAAAAAAGATGATACAAAGGAAACAGATTCTTTATCAGATGAAGTTACACACAATAGCAATCAGA
  ATAACAGCAATTGTTCTTCTCCATCTCGGATGTCTGATTCAGTTTCTCTTAATACTGATAGTAGTCAAGA
  CACCTCACTCTGCTCTCCAGTGAAACAAACTCATATTGATATTAATTCCAAAATCAGGCAAGAAGATGAA
  AATTTTAACAGCCTTTTACAAAATGGAGATATTTTAAACAGTTCAACAGAGGAAAAGTTCAAAGCTCATG
  ATAAAAAAGATTTTAACTTACCTGAATATGATTTGAATGTTGAAGAGCGATTAGTTCTAATTGAGAAAAG
  TGTTGACTCAACAGCCACAGCTGATGACACTCACAAATTAGATCATATCAATATGAATCTTAATAAACTT
  ATAACTAATGATACATTTCAACCAGAGATCATGGAAAGATCAAAAACACAGGATATTGTGCTTGGAACAA
  GCTTTTTAAGCATTAATTCTAAAGAGGAAACTGAGCACTTGGAAAATGGAAACAAGTATCCTAATTTGGA
  ATCCGTAAATAAGGTAAATGGACATTCTGAGGAAACTTCCCAGTCTCCTAATAGGACTGAACCACATGAC
  AGTGATTGTTCTGTTGACTTAGGTATTTCCAAAAGCACTGAAGATCTCTCCCCTCAGAAAAGTGGTCCAG
  TTGGATCTGTTGTGAAATCTCATAGCATAACTAATATGGAGATTGGAGGGCTAAAAATCTATGATATTCT
  TAGTGATAATGGACCTCAGCAGCCAAGTACAACCGTTAAAATCACATCTGCTGTTGATGGAAAAAATATA
  GTCAGGAGCAAGTCTGCCACACTGTTGTATGATCAACCATTGCAGGTATTTACTGGTTCTTCCTCATCTT
  CTGATTTAATATCAGGAACAAAGGCAATTTTCAAGTTTGATTCAAATCATAATCCCGAAGAGCCAAATAT
  AATAAGAGGCCCCACAAGTGGCCCACAATCTGCACCTCAAATATATGGTCCTCCACAGTATAATATCCAA
  TACAGTAGCAGTGCTGCAGTCAAAGACACTTTGTGGCACTCCAAACAAAATCCCCAAATAGACCATGCCA
  GTTTTCCTCCTCAGCTCCTTCCTAGATCAGAGAGCACAGAAAATCAAAGTTATGCTAAACATTCTGCCAA
  TATGAATTTCTCTAATCATAACAATGTTCGAGCTAATACTGCATACCATTTACATCAGAGACTTGGCCCA
  GCAAGACATGGGGAAATGTGGGCCATCTCACCAAACGACCGACTTATTCCTGCAGTAACTCGAAGTACAA
  TCCAGCGACAAAGTAGTGTGTCCTCCACAGCCTCTGTAAATCTTGGTGATCCAGGCTCTACAAGGCGGGC
  TCAGATTCCTGAAGGAGATTATTTATCATACAGAGAGTTCCACTCAGCGGGAAGAACTCCTCCAATGATG
  CCAGGATCACAGAGACCCCTTTCTGCACGAACATACAGCATAGATGGTCCAAATGCATCAAGACCTCAGA
  GTGCTCGACCCTCTATTAATGAAATACCAGAGAGAACTATGTCAGTTAGTGATTTCAATTATTCACGGAC
  TAGTCCTTCAAAAAGACCAAATGCAAGGGTTGGTTCTGAGCATTCTTTATTAGATCCTCCAGGAAAAAGT
  AAAGTTCCTCGTGACTGGAGAGAACAAGTACTTCGACATATTGAAGCCAAAAAGTTAGAAAAGAAGCATC
  CCCAGACATCCAGTTCAGGAGATCCTTGTCAAGATGGTATATTCATTTCAGGACAGCAGAACTACTCATC
  AGCCACACTTAGTCACAAAGATGTTCCTCCAGACAGCTTGATGAAAATGCCTTTGAGTAATGGACAGATG
  GGCCAGCCTCTCAGGCCTCAGGCAAATTATAGTCAAATACATCACCCCCCTCAGGCATCTGTGGCAAGGC
  ATCCCTCTAGAGAACAACTAATTGATTACTTGATGCTGAAAGTGGCCCACCAGCCTCCATATACACAGCC
  CCATTGTTCTCCTAGACAAGGCCATGAACTGGCAAAACAAGAGATTCGAGTGAGGGTTGAAAAGGATCCA
  GAACTTGGATTTAGCATATCAGGTGGTGTCGGGGGTAGAGGAAACCCATTCAGACCTGATGATGATGGTA
  TATTTGTAACAAGGGTACAACCTGAAGGACCAGCATCAAAATTACTGCAGCCAGGTGATAAAATTATTCA
  GGCTAATGGCTACAGTTTTATAAATATTGAACATGGACAAGCAGTGTCCTTGCTAAAAACTTTCCAGAAT
  ACAGTTGAACTCATCATTGTACGAGAAGTTTCCTCA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
  Protein Sequence

  >RC235298 representing NM_001253697
  Red=Cloning site Green=Tags(s)
  
  MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQS
  LHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNL
  TQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLK
  EFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITT
  LKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVL
  FLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM
  VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDE
  LKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTTTVKSKVDEREKYMIGNSVQK
  ISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQPKVVALS
  NNKKDDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDE
  NFNSLLQNGDILNSSTEEKFKAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKL
  ITNDTFQPEIMERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD
  SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVKITSAVDGKNI
  VRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRGPTSGPQSAPQIYGPPQYNIQ
  YSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQSYAKHSANMNFSNHNNVRANTAYHLHQRLGP
  ARHGEMWAISPNDRLIPAVTRSTIQRQSSVSSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMM
  PGSQRPLSARTYSIDGPNASRPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKS
  KVPRDWREQVLRHIEAKKLEKKHPQTSSSGDPCQDGIFISGQQNYSSATLSHKDVPPDSLMKMPLSNGQM
  GQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQEIRVRVEKDP
  ELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFQN
  TVELIIVREVSS
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_001253697
• ORF Size: 4236 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001253697.1, NP_001240626.1
• RefSeq Size: 7042
• RefSeq ORF: 4239
• Locus ID: 55914
• Protein Families: Druggable Genome
• Protein Pathways: NOD-like receptor signaling pathway
• MW: 158.7 kDa
• Gene Summary: This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]