Rho GTPase activating protein 24 (ARHGAP24) (NM_001287805) Human Tagged ORF Clone

CAT#: RC239254

ARHGAP24 (myc-DDK-tagged) - Human Rho GTPase activating protein 24 (ARHGAP24), transcript variant 4

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: ARHGAP24
• Synonyms: FILGAP; p73; p73RhoGAP; RC-GAP72; RCGAP72
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RC239254 representing NM_001287805
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGTTTGTGCAAGGAGGCGATCGAGATCGGATGACAGCAAATCATGAAAGCTACCTCCTCATGGCAAGCA
  CCCAGAATGATATGGAAGACTGGGTGAAGTCAATCCGCCGAGTCATATGGGGACCTTTCGGAGGAGGCAT
  TTTTGGACAGAAACTGGAGGATACTGTTCGTTATGAGAAGAGATATGGGAACCGTCTGGCTCCGATGTTG
  GTGGAGCAGTGCGTGGACTTTATCCGACAAAGGGGGCTGAAAGAAGAGGGTCTCTTTCGACTGCCAGGCC
  AGGCTAATCTTGTTAAGGAGCTCCAAGATGCCTTTGACTGTGGGGAGAAGCCATCATTTGACAGCAACAC
  AGATGTACACACGGTGGCATCACTTCTTAAGCTGTACCTCCGAGAACTTCCAGAACCAGTTATTCCTTAT
  GCGAAGTATGAAGATTTTTTGTCATGTGCCAAACTGCTCAGCAAGGAAGAGGAAGCAGGTGTTAAGGAAT
  TAGCAAAGCAGGTGAAGAGTTTGCCAGTGGTAAATTACAACCTCCTCAAGTATATTTGCAGATTCTTGGA
  TGAAGTACAGTCCTACTCGGGAGTTAACAAAATGAGTGTGCAGAACTTGGCAACGGTCTTTGGTCCTAAT
  ATCCTGCGCCCCAAAGTGGAAGATCCTTTGACTATCATGGAGGGCACTGTGGTGGTCCAGCAGTTGATGT
  CAGTGATGATTAGCAAACATGATTGCCTCTTTCCCAAAGATGCAGAACTACAAAGCAAGCCCCAAGATGG
  AGTGAGCAACAACAATGAAATTCAGAAGAAAGCCACCATGGGGCAGTTACAGAACAAGGAGAACAATAAC
  ACCAAGGACAGCCCTAGTAGGCAGTGCTCCTGGGACAAGTCTGAGTCACCCCAGAGAAGCAGCATGAACA
  ATGGATCCCCCACAGCTCTATCAGGCAGCAAAACCAACAGCCCAAAGAACAGTGTTCACAAGCTAGATGT
  GTCTAGAAGCCCCCCTCTCATGGTCAAAAAGAACCCAGCCTTTAATAAGGGTAGTGGGATAGTTACCAAT
  GGGTCCTTCAGCAGCAGTAATGCAGAAGGTCTTGAGAAAACCCAAACCACCCCCAATGGGAGCCTACAGG
  CCAGAAGGAGCTCTTCACTGAAGGTATCTGGTACCAAAATGGGCACGCACAGTGTACAGAATGGAACGGT
  GCGCATGGGCATTTTGAACAGCGACACACTCGGGAACCCCACAAATGTTCGAAACATGAGCTGGCTGCCA
  AATGGCTATGTGACCCTGAGGGATAACAAGCAGAAAGAACAAGCTGGAGAGTTAGGCCAGCACAACAGAC
  TGTCCACCTATGATAATGTCCATCAACAGTTCTCCATGATGAACCTTGATGACAAGCAGAGCATTGACAG
  TGCTACCTGGTCCACTTCCTCCTGTGAAATCTCCCTCCCTGAGAACTCCAACTCCTGTCGCTCTTCTACC
  ACCACCTGCCCAGAGCAAGACTTTTTTGGGGGGAACTTTGAGGACCCTGTTTTGGATGGGCCCCCGCAGG
  ACGACCTTTCCCACCCCAGGGACTATGAAAGCAAAAGTGACCACAGGAGTGTGGGAGGTCGAAGTAGTCG
  TGCCACCAGTAGCAGTGACAACAGTGAGACATTTGTGGGCAACAGCAGCAGCAACCACAGTGCACTGCAC
  AGTTTAGTTTCCAGCCTGAAACAGGAAATGACCAAACAGAAGATAGAGTATGAGTCCAGGATAAAGAGCT
  TAGAACAGCGAAACTTGACTTTGGAAACAGAAATGATGAGCCTCCATGATGAACTGGATCAGGAGAGGAA
  AAAGTTCACAATGATAGAAATAAAAATGCGAAATGCCGAGCGAGCAAAAGAAGATGCCGAGAAAAGAAAT
  GACATGCTACAGAAAGAAATGGAGCAGTTTTTTTCCACGTTTGGAGAACTGACAGTGGAACCCAGGAGAA
  CCGAGAGAGGAAACACAATATGGATTCAG
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
  Protein Sequence

  >RC239254 representing NM_001287805
  Red=Cloning site Green=Tags(s)
  
  MFVQGGDRDRMTANHESYLLMASTQNDMEDWVKSIRRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPML
  VEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPY
  AKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPN
  ILRPKVEDPLTIMEGTVVVQQLMSVMISKHDCLFPKDAELQSKPQDGVSNNNEIQKKATMGQLQNKENNN
  TKDSPSRQCSWDKSESPQRSSMNNGSPTALSGSKTNSPKNSVHKLDVSRSPPLMVKKNPAFNKGSGIVTN
  GSFSSSNAEGLEKTQTTPNGSLQARRSSSLKVSGTKMGTHSVQNGTVRMGILNSDTLGNPTNVRNMSWLP
  NGYVTLRDNKQKEQAGELGQHNRLSTYDNVHQQFSMMNLDDKQSIDSATWSTSSCEISLPENSNSCRSST
  TTCPEQDFFGGNFEDPVLDGPPQDDLSHPRDYESKSDHRSVGGRSSRATSSSDNSETFVGNSSSNHSALH
  SLVSSLKQEMTKQKIEYESRIKSLEQRNLTLETEMMSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRN
  DMLQKEMEQFFSTFGELTVEPRRTERGNTIWIQ
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_001287805
• ORF Size: 1989 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001287805.1, NP_001274734.1
• RefSeq Size: 4010
• RefSeq ORF: 1992
• Locus ID: 83478
• MW: 74.9 kDa
• Gene Summary: This gene encodes a Rho-GTPase activating protein, which is specific for the small GTPase family member Rac. Binding of the encoded protein by filamin A targets it to sites of membrane protrusion, where it antognizes Rac. This results in suppression of lamellae formation and promotion of retraction to regulate cell polarity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]