KDM5C (NM_001282622) Human Tagged ORF Clone

CAT#: RC240178

KDM5C (myc-DDK-tagged) - Human lysine (K)-specific demethylase 5C (KDM5C), transcript variant 3

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: KDM5C
• Synonyms: DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ; MRXSJ; SMCX; XE169
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RC240178 ORF sequence
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGAGCCGGGGTCCGACGATTTCCTACCGCCACCGGAGTGCCCGGTGTTCGAGCCTAGCTGGGCCGAGT
  TCCGAGACCCTCTTGGCTACATCGCGAAAATCAGGCCCATCGCAGAGAAATCGGGCATTTGCAAGATCCG
  CCCACCCGCGGACTGGCAGCCACCCTTTGCTGTGGAAGTGGACAACTTCAGGTTTACCCCCCGAATCCAG
  AGGCTGAATGAGCTAGAGGCCCAGACGAGAGTGAAACTGAACTACTTGGACCAGATTGCCAAATTCTGGG
  AAATCCAGGGCTCCTCCTTAAAGATTCCCAATGTAGAACGGCGGATCTTGGACCTCTACAGTCTCAGCAA
  AATTGTGGTGGAGGAAGGTGGTTATGAAGCTATCTGCAAGGACCGTCGGTGGGCTCGGGTAGCCCAGCGC
  CTCAACTATCCACCAGGCAAAAATATTGGCTCCTTGCTACGCTCCCACTACGAACGCATTGTTTATCCCT
  ATGAAATGTACCAGTCTGGAGCCAACCTTGTGTGTAACACACGTCCATTTGATAATGAGGAGAAGGACAA
  GGAATACAAACCCCACAGCATCCCCCTACGACAGTCTGTGCAGCCTTCCAAGTTCAACAGCTATGGCCGG
  CGGGCCAAGAGACTGCAGCCTGATCCGGAACCCACAGAGGAAGACATTGAGAAGAATCCAGAGCTGAAAA
  AGCTACAGATCTATGGGGCAGGCCCCAAGATGATGGGCCTGGGCCTCATGGCCAAAGACAAGACTCTGCG
  GAAGAAAGATAAGGAGGGGCCTGAGTGTCCCCCCACAGTAGTGGTGAAGGAGGAGTTAGGTGGGGATGTG
  AAGGTGGAGTCAACATCGCCTAAGACCTTCCTGGAGAGCAAGGAGGAGCTGAGTCACAGCCCAGAACCCT
  GCACCAAGATGACCATGAGGCTACGGAGGAACCACAGCAATGCCCAGTTTATTGAGTCATATGTCTGCCG
  GATGTGTTCTCGAGGGGATGAGGATGACAAGCTCCTGCTGTGTGATGGCTGTGATGACAACTACCACATC
  TTCTGCCTGCTGCCTCCTCTGCCTGAGATCCCCAAGGGTGTCTGGCGGTGCCCAAAGTGTGTCATGGCGG
  AGTGTAAGCGGCCCCCAGAAGCCTTTGGCTTTGAGCAGGCTACCCGGGAATACACTCTGCAGAGCTTTGG
  CGAGATGGCCGACTCCTTTAAAGCTGACTACTTCAACATGCCCGTGCATATGGTGCCCACAGAACTTGTG
  GAGAAGGAGTTCTGGAGGCTGGTAAATAGCATTGAGGAAGATGTGACTGTTGAGTATGGAGCTGACATCC
  ATTCCAAAGAATTTGGCAGCGGTTTCCCTGTCAGTGACAGTAAACGGCACCTAACCCCCGAAGAGGAGGA
  GTATGCTACCAGTGGTTGGAACCTAAATGTGATGCCGGTGTTGGAACAGTCTGTACTGTGCCACATCAAT
  GCAGATATCTCTGGCATGAAGGTGCCCTGGCTCTACGTGGGCATGGTCTTCTCAGCCTTTTGCTGGCATA
  TTGAGGATCACTGGAGTTACTCCATTAACTACCTCCACTGGGGTGAGCCGAAGACCTGGTATGGGGTGCC
  CTCACTTGCAGCAGAACATTTGGAAGAAGTGATGAAGAAGCTGACACCTGAACTATTTGATAGCCAGCCT
  GACCTCCTGCACCAACTTGTCACCCTCATGAATCCCAACACCCTCATGTCCCATGGTGTGCCAGTTGTCC
  GCACAAACCAGTGTGCAGGAGAGTTTGTCATCACCTTCCCCCGTGCTTACCACAGCGGCTTCAACCAAGG
  CTACAACTTTGCCGAGGCTGTCAACTTTTGCACTGCTGACTGGTTGCCTGCTGGGCGCCAGTGCATTGAG
  CACTACCGCCGGCTCCGGAGATACTGCGTCTTCTCCCATGAGGAGCTTATCTGCAAGATGGCTGCCTGCC
  CAGAGAAGCTAGACCTGAACCTGGCGGCAGCTGTGCATAAGGAGATGTTCATCATGGTGCAAGAAGAGCG
  GCGTCTACGAAAGGCCCTGCTGGAGAAGGGTATCACAGAGGCTGAGCGAGAGGCTTTCGAGCTGCTCCCA
  GATGATGAGCGCCAGTGTATCAAGTGCAAGACTACGTGTTTCCTGTCAGCCCTGGCCTGCTACGACTGCC
  CAGACGGCCTTGTCTGCCTTTCCCACATCAATGATCTCTGCAAGTGCTCCAGTAGCCGGCAGTACCTGCG
  GTATCGGTATACCTTGGATGAGCTTCCTGCCATGCTGCATAAGCTGAAGGTTCGGGCTGAGTCCTTTGAC
  ACCTGGGCCAACAAAGTGCGAGTGGCCCTGGAGGTGGAGGATGGGCGGAAGCGCAGCCTTGAAGAACTGA
  GGGCACTAGAGTCTGAAGCCCGTGAGCGGAGGTTTCCTAATAGTGAGCTGCTGCAGCAACTAAAGAACTG
  CCTGAGTGAGGCAGAGGCTTGCGTGTCCCGAGCTCTGGGACTGGTCAGCGGCCAGGAAGCTGGCCCCCAC
  AGGGTGGCTGGTCTACAGATGACCCTGACTGAGCTCCGGGCCTTTCTGGACCAGATGAACAACCTGCCTT
  GCGCCATGCACCAGATTGGGGATGTCAAGGGTGTTCTGGAACAGGTGGAGGCCTACCAGGCTGAGGCTCG
  TGAGGCCCTGGCCTCACTGCCCTCCAGTCCAGGGCTACTGCAGTCCCTGTTGGAGAGGGGGCGGCAGCTG
  GGGGTGGAGGTGCCTGAGGCCCAGCAGCTCCAGCGGCAGGTGGAACAGGCGCGATGGCTGGATGAGGTGA
  AACGCACACTGGCCCCCTCAGCCCGAAGGGGCACCTTGGCTGTCATGCGAGGACTGTTGGTCGCGGGTGC
  CAGTGTAGCCCCTAGCCCTGCTGTGGATAAAGCCCAGGCCGAGCTGCAGGAACTGCTGACCATTGCTGAA
  CGCTGGGAGGAGAAAGCCCACCTCTGCCTGGAGGCCAGGCAGAAGCATCCACCAGCCACACTTGAGGCCA
  TAATCCGTGAAGCGGAAAACATCCCTGTTCACCTGCCCAACATCCAGGCTCTCAAGGAGGCTCTTGCTAA
  GGCCCGGGCCTGGATTGCTGATGTTGATGAGATCCAAAATGGTGACCACTACCCCTGCCTGGATGACTTG
  GAGGGCCTAGTAGCTGTGGGCCGGGACCTACCTGTGGGGCTGGAGGAGCTGAGACAGCTAGAGCTACAGG
  TACTGACAGCGCACTCCTGGAGGGAGAAGGCCTCCAAGACCTTCCTCAAGAAAAATTCTTGCTACACGCT
  GCTGGAGGTTCTCTGCCCATGTGCAGATGCCGGCTCAGACAGCACCAAGCGCAGCCGGTGGATGGAGAAG
  GAGCTGGGGTTGTACAAATCTGACACAGAGCTGCTGGGGCTGTCTGCGCAGGACCTCAGGGACCCAGGCT
  CTGTGATCGTGGCCTTCAAGGAGGGGGAACAGAAGGAGAAGGAGGGTATCCTGCAGCTGCGTCGCACCAA
  TTCGGCCAAGCCCAGTCCACTGGCATCATCGAGCACGGCCTCCTCTACAACCTCTATCTGTGTGTGTGGG
  CAGGTGCTGGCTGGGGCGGGAGCTCTGCAGTGTGACCTGTGTCAGGACTGGTTCCATGGGCGGTGTGTGT
  CAGTGCCTCGCCTCCTCAGCTCTCCGAGGCCCAATCCCACCTCATCCCCACTGCTGGCCTGGTGGGAATG
  GGACACCAAATTCCTGTGTCCACTGTGTATGCGCTCAAGGCGCCCGCGCCTGGAGACCATCCTGGCACTG
  CTGGTAGCCCTGCAGAGACTGCCTGTGCGGCTGCCCGAGGGCGAGGCCCTGCAGTGCCTCACAGAGAGGG
  CCATCAGCTGGCAAGGCCGCGCCAGGCAGGCTCTGGCCTCTGAAGATGTGACTGCTCTTTTGGGACGGCT
  GGCTGAGCTCCGCCAACGGCTACAGGCTGAACCTAGACCTGAGGAGCCTCCTAACTACCCTGCAGCCCCT
  GCTTCTGACCCCCTCAGAGAGGGCAGTGGCAAGGATATGCCTAAGGTCCAGGGCTTACTGGAGAATGGAG
  ACAGTGTGACCAGTCCTGAGAAGGTAGCCCCGGAGGAGGGCTCAGGTAAGAGAGATCTGGAGCTGCTGTC
  CTCGCTGTTGCCACAGTTGACTGGCCCTGTGTTGGAACTGCCTGAGGCAACCCGGGCCCCCTTGGAGGAG
  CTCATGATGGAGGGGGACCTGCTCGAGGTGACCCTGGATGAGAACCACAGCATATGGCAGCTGCTGCAGG
  CTGGACAGCCCCCAGACCTGGAGAGGATCCGCACACTTCTGGAGCTGGAGAAGGCAGAGCGTCACGGGAG
  TCGGGCTCGGGGCCGGGCCCTGGAGAGGCGGCGGCGGCGGAAGGTGGATCGGGGTGGGGAGGGCGATGAC
  CCAGCCCGAGAGGAGCTAGAGCCAAAGAGGGTACGGAGCTCAGGGCCAGAGGCTGAGGAGGTCCAGGAGG
  AGGAAGAGCTGGAGGAGGAGACTGGGGGTGAGGGCCCCCCTGCACCCATCCCCACCACTGGCAGCCCCAG
  CACCCAGGAGAACCAGAATGGCTTGGAACCGGCGGAAGGGACCACTTCAGGCCCCTCGGCCCCTTTCTCC
  ACTCTGACTCCCCGGCTGCATCTGCCCTGCCCACAGCAGCCGCCTCAGCAACAGTTG
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
  Protein Sequence

  >RC240178 protein sequence
  Red=Cloning site Green=Tags(s)
  
  MEPGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRIQ
  RLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVVEEGGYEAICKDRRWARVAQR
  LNYPPGKNIGSLLRSHYERIVYPYEMYQSGANLVCNTRPFDNEEKDKEYKPHSIPLRQSVQPSKFNSYGR
  RAKRLQPDPEPTEEDIEKNPELKKLQIYGAGPKMMGLGLMAKDKTLRKKDKEGPECPPTVVVKEELGGDV
  KVESTSPKTFLESKEELSHSPEPCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHI
  FCLLPPLPEIPKGVWRCPKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKADYFNMPVHMVPTELV
  EKEFWRLVNSIEEDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYATSGWNLNVMPVLEQSVLCHIN
  ADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKKLTPELFDSQP
  DLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIE
  HYRRLRRYCVFSHEELICKMAACPEKLDLNLAAAVHKEMFIMVQEERRLRKALLEKGITEAEREAFELLP
  DDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPAMLHKLKVRAESFD
  TWANKVRVALEVEDGRKRSLEELRALESEARERRFPNSELLQQLKNCLSEAEACVSRALGLVSGQEAGPH
  RVAGLQMTLTELRAFLDQMNNLPCAMHQIGDVKGVLEQVEAYQAEAREALASLPSSPGLLQSLLERGRQL
  GVEVPEAQQLQRQVEQARWLDEVKRTLAPSARRGTLAVMRGLLVAGASVAPSPAVDKAQAELQELLTIAE
  RWEEKAHLCLEARQKHPPATLEAIIREAENIPVHLPNIQALKEALAKARAWIADVDEIQNGDHYPCLDDL
  EGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEK
  ELGLYKSDTELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLASSSTASSTTSICVCG
  QVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILAL
  LVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAP
  ASDPLREGSGKDMPKVQGLLENGDSVTSPEKVAPEEGSGKRDLELLSSLLPQLTGPVLELPEATRAPLEE
  LMMEGDLLEVTLDENHSIWQLLQAGQPPDLERIRTLLELEKAERHGSRARGRALERRRRRKVDRGGEGDD
  PAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQENQNGLEPAEGTTSGPSAPFS
  TLTPRLHLPCPQQPPQQQL
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_001282622
• ORF Size: 4677 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001282622.1, NM_001282622.2, NP_001269551.1
• RefSeq Size: 6644
• RefSeq ORF: 4680
• Locus ID: 8242
• Protein Families: Druggable Genome, Transcription Factors
• MW: 175.6 kDa
• Gene Summary: This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]