KCTD17 (NM_024681) Human Tagged ORF Clone

CAT#: RG206070

KCTD17 (GFP-tagged) - Human potassium channel tetramerisation domain containing 17 (KCTD17)

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: TurboGFP
• Symbol: KCTD17
• Synonyms: FLJ12242; FLJ98761
• Vector: pCMV6-AC-GFP
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RG206070 representing NM_024681
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGAGGATGGAGGCCGGGGAGGCAGCGCCGCCGGCGGGGGCGGGCGGCCGCGCCGCAGGCGGCTGGGGCA
  AGTGGGTGCGGCTCAACGTGGGGGGCACGGTGTTCCTGACCACCCGGCAGACGCTGTGCCGCGAGCAGAA
  GTCCTTCCTCAGCCGCCTGTGCCAGGGGGAAGAGCTGCAGTCGGACCGGGATGAGACCGGGGCCTACCTC
  ATTGACCGTGACCCCACCTACTTCGGGCCCATCCTGAACTTCCTCCGGCATGGCAAGCTGGTGCTGGACA
  AGGACATGGCTGAGGAGGGGGTCCTGGAGGAAGCCGAGTTCTACAACATCGGCCCGCTGATCCGCATCAT
  CAAAGACCGGATGGAAGAGAAGGACTACACGGTCACCCAGGTCCCACCCAAGCATGTGTACCGCGTGCTG
  CAGTGCCAGGAGGAGGAGCTCACGCAAATGGTCTCCACCATGTCTGATGGCTGGCGCTTCGAGCAGCTGG
  TGAACATCGGCTCCTCCTACAACTACGGCAGCGAGGACCAGGCAGAGTTCCTGTGTGTGGTGTCCAAGGA
  GCTCCACAGCACCCCAAACGGGCTGAGCTCAGAGTCCAGCCGCAAAACCAAGAGCACGGAGGAGCAGCTG
  GAGGAGCAGCAGCAGCAGGAGGAGGAGGTGGAGGAGGTGGAGGTGGAACAGGTGCAGGTGGAGGCAGATG
  CACAGGAGAAAGGTTCCCGTCCGCACCCTCTCAGACCTGAGGCTGAGCTTGCAGTGAGGGCTTCTCCTCG
  GCCCCTCGCCCGCCCCCAGAGCTGCCATCCCTGCTGTTACAAGCCAGAGGCACCCGGATGTGAGGCCCCA
  GATCACCTCCAGGGACTTGGGGTTCCCATC
  
  ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA
  Protein Sequence

  >RG206070 representing NM_024681
  Red=Cloning site Green=Tags(s)
  
  MRMEAGEAAPPAGAGGRAAGGWGKWVRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQSDRDETGAYL
  IDRDPTYFGPILNFLRHGKLVLDKDMAEEGVLEEAEFYNIGPLIRIIKDRMEEKDYTVTQVPPKHVYRVL
  QCQEEELTQMVSTMSDGWRFEQLVNIGSSYNYGSEDQAEFLCVVSKELHSTPNGLSSESSRKTKSTEEQL
  EEQQQQEEEVEEVEVEQVQVEADAQEKGSRPHPLRPEAELAVRASPRPLARPQSCHPCCYKPEAPGCEAP
  DHLQGLGVPI
  
  TRTRRLE - GFP Tag - V
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_024681
• ORF Size: 870 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_024681.2, NP_078957.2
• RefSeq Size: 1704
• RefSeq ORF: 894
• Locus ID: 79734
• Protein Families: Ion Channels: Other
• Gene Summary: This gene encodes a protein that belongs to a conserved family of potassium channel tetramerization domain (KCTD)-containing proteins. The encoded protein functions in ciliogenesis by acting as a substrate adaptor for the cullin3-based ubiquitin-conjugating enzyme E3 ligase, and targets trichoplein, a keratin-binding protein, for degradation via polyubiquitinylation. A mutation in this gene is associated with autosomal dominant myoclonic dystonia 26. [provided by RefSeq, Nov 2016]