FCP1 (CTDP1) (NM_048368) Human Tagged ORF Clone

CAT#: RG209100

CTDP1 (GFP-tagged) - Human CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 (CTDP1), transcript variant 2

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: TurboGFP
• Symbol: CTDP1
• Synonyms: CCFDN; FCP1
• Vector: pCMV6-AC-GFP
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RG209100 representing NM_048368
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGAGGTGCCGGCCGCGGGTCGCGTTCCTGCCGAGGGCGCCCCGACGGCGGCTGTGGCCGAGGTGCGCT
  GCCCGGGGCCCGCGCCGCTGCGCCTGCTGGAGTGGAGGGTGGCGGCGGGCGCGGCCGTGCGCATCGGCTC
  GGTGCTGGCCGTGTTCGAGGCCGCCGCCTCCGCGCAGTCCGCCGGGGCCTCTCAGTCCCGTGTAGCCTCC
  GGGGGCTGCGTGCGCCCCGCGCGGCCGGAACGCAGGCTGAGGTCGGAGCGCGCGGGCGTGGTGCGGGAGC
  TGTGCGCGCAGCCGGGCCAGGTGGTCGCCCCAGGAGCGGTTCTGGTGAGGTTGGAAGGATGCAGCCACCC
  GGTTGTCATGAAAGGCCTGTGTGCTGAATGTGGCCAAGACCTCACCCAGTTGCAGAGTAAGAACGGGAAG
  CAGCAGGTGCCGCTGTCCACGGCGACCGTGTCCATGGTGCACAGCGTGCCGGAGTTGATGGTGAGCTCCG
  AGCAAGCTGAACAGCTGGGAAGAGAAGACCAGCAGCGACTGCACCGAAACCGGAAGCTGGTGCTCATGGT
  GGACTTGGACCAGACGTTGATTCACACAACCGAGCAGCACTGTCAGCAGATGTCGAATAAAGGCATCTTT
  CACTTCCAGCTGGGCCGGGGTGAGCCCATGCTGCACACGCGCCTGCGTCCACACTGCAAGGACTTCCTGG
  AGAAGATCGCCAAGCTGTACGAGCTGCACGTCTTCACCTTCGGCAGCCGGCTGTACGCACACACCATCGC
  AGGCTTTTTAGACCCCGAGAAGAAGCTTTTTTCTCACCGAATATTATCAAGGGATGAATGTATTGACCCA
  TTTTCTAAAACGGGAAACCTTAGAAATCTCTTTCCTTGTGGAGACTCAATGGTTTGCATTATTGATGATC
  GAGAAGATGTCTGGAAGTTTGCCCCCAATCTGATAACTGTGAAGAAATATGTATACTTCCAGGGCACGGG
  TGATATGAATGCGCCCCCTGGGTCCCGAGAATCTCAGACGAGAAAGAAAGTAAATCATTCTCGAGGCACT
  GAGGTCTCAGAGCCATCTCCGCCCGTGAGAGACCCTGAGGGGGTAACGCAGGCCCCTGGAGTGGAGCCCA
  GCAATGGCCTGGAGAAGCCTGCACGGGAGCTGAACGGCAGCGAGGCCGCCACCCCGCGGGACTCACCCCG
  CCCCGGGAAGCCAGACGAGAGGGACATCTGGCCCCCTGCCCAGGCCCCCACCAGCAGCCAAGAGCTGGCA
  GGCGCTCCTGAGCCCCAGGGATCCTGTGCGCAGGGTGGCCGGGTGGCACCGGGACAGCGGCCTGCCCAGG
  GTGCCACGGGCACTGACCTGGACTTTGACTTATCCAGCGACAGCGAGAGCAGCAGTGAGTCCGAGGGCAC
  GAAGTCCTCCTCCTCCGCCTCTGATGGCGAAAGCGAGGGGAAAAGAGGCCGGCAGAAGCCGAAGGCTGCC
  CCAGAGGGAGCCGGGGCGCTGGCACAGGGCAGTTCCCTGGAGCCGGGGCGGCCTGCAGCACCGAGTCTCC
  CCGGAGAGGCCGAGCCTGGCGCGCATGCCCCGGACAAGGAGCCTGAGCTGGGTGGGCAGGAGGAGGGCGA
  GCGGGATGGCCTCTGCGGCCTGGGCAACGGCTGTGCCGACAGGAAGGAGGCGGAGACCGAGTCACAGAAC
  AGCGAGCTGTCGGGGGTCACTGCGGGTGAGTCCCTGGACCAGAGCATGGAGGAGGAGGAGGAGGAGGACA
  CGGATGAGGATGACCACCTCATCTACCTGGAGGAGATCCTGGTCCGTGTACACACTGACTACTATGCCAA
  GTATGACCGCTACCTCAACAAGGAGATCGAGGAGGCGCCGGACATCCGCAAGATCGTGCCGGAGCTCAAG
  AGCAAGGTGCTGGCAGACGTGGCCATAATTTTCAGTGGGCTACACCCGACAAACTTCCCGATAGAGAAGA
  CGCGGGAGCATTACCACGCCACGGCGCTGGGAGCGAAGATCCTCACTCGGCTGGTGCTGAGCCCCGACGC
  CCCTGACAGGGCCACGCACCTGATCGCCGCGCGAGCTGGCACAGAGAAGGTGCTGCAGGCACAGGAGTGC
  GGACACCTGCACGTGGTCAACCCTGACTGGCTGTGGAGCTGCCTGGAGCGCTGGGACAAGGTGGAGGAGC
  AGCTCTTCCCGCTCAGGGACGATCACACCAAGGCACAGAGGGAGAACAGCCCTGCGGCCTTTCCCGACCG
  GGAGGGTGTGCCCCCCACCGCCTTGTTCCACCCGATGCCGGTTCTTCCCAAGGCCCAGCCTGGCCCCGAG
  GTTCGGATCTACGACTCCAACACGGGGAAGCTCATCAGGACGGGCGCCCGGGGGCCCCCAGCACCCTCCA
  GCTCCCTACCCATCCGCCAGGAGCCCTCTTCCTTCAGGTGGACGACATCCTTGGAGAAGGCAGCGACGAC
  AGCGACAGCGAGAAGAGGAGGCCTGAGGAGCAGGAGGAGGAGCCCCAGCCCCGGAAGCCAGGGACCCGCA
  GGGAGCGGACGCTCGGGGCACCTGCGTCCAGCGAGAGGAGCGCGGCAGGGGGCCGGGGGCCCAGAGGCCA
  CAAGAGGAAGC
  
  ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA
  Protein Sequence

  >RG209100 representing NM_048368
  Red=Cloning site Green=Tags(s)
  
  MEVPAAGRVPAEGAPTAAVAEVRCPGPAPLRLLEWRVAAGAAVRIGSVLAVFEAAASAQSAGASQSRVAS
  GGCVRPARPERRLRSERAGVVRELCAQPGQVVAPGAVLVRLEGCSHPVVMKGLCAECGQDLTQLQSKNGK
  QQVPLSTATVSMVHSVPELMVSSEQAEQLGREDQQRLHRNRKLVLMVDLDQTLIHTTEQHCQQMSNKGIF
  HFQLGRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILSRDECIDP
  FSKTGNLRNLFPCGDSMVCIIDDREDVWKFAPNLITVKKYVYFQGTGDMNAPPGSRESQTRKKVNHSRGT
  EVSEPSPPVRDPEGVTQAPGVEPSNGLEKPARELNGSEAATPRDSPRPGKPDERDIWPPAQAPTSSQELA
  GAPEPQGSCAQGGRVAPGQRPAQGATGTDLDFDLSSDSESSSESEGTKSSSSASDGESEGKRGRQKPKAA
  PEGAGALAQGSSLEPGRPAAPSLPGEAEPGAHAPDKEPELGGQEEGERDGLCGLGNGCADRKEAETESQN
  SELSGVTAGESLDQSMEEEEEEDTDEDDHLIYLEEILVRVHTDYYAKYDRYLNKEIEEAPDIRKIVPELK
  SKVLADVAIIFSGLHPTNFPIEKTREHYHATALGAKILTRLVLSPDAPDRATHLIAARAGTEKVLQAQEC
  GHLHVVNPDWLWSCLERWDKVEEQLFPLRDDHTKAQRENSPAAFPDREGVPPTALFHPMPVLPKAQPGPE
  VRIYDSNTGKLIRTGARGPPAPSSSLPIRQEPSSFRWTTSLEKAATTATARRGGLRSRRRSPSPGSQGPA
  GSGRSGHLRPARGARQGAGGPEATRGS
  
  TRTRRLE - GFP Tag - V
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_048368
• ORF Size: 3599 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_048368.2, NP_430255.2
• RefSeq Size: 3612
• RefSeq ORF: 2604
• Locus ID: 9150
• Domains: BRCT, CPDc
• Protein Families: Druggable Genome, Phosphatase, Transcription Factors
• Gene Summary: This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]