SESN1 (NM_014454) Human Tagged ORF Clone
CAT#: RG211305
- TrueORF®
SESN1 (GFP-tagged) - Human sestrin 1 (SESN1), transcript variant 1
"NM_014454" in other vectors (4)
Product Images
![](https://cdn.origene.com/img/defaults-img-expression-plasmids.jpg)
Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | TurboGFP |
Symbol | SESN1 |
Synonyms | PA26; SEST1 |
Vector | pCMV6-AC-GFP |
E. coli Selection | Ampicillin (100 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>RG211305 representing NM_014454
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGCTGAAGGAGAGAATGAAGTGAGATGGGATGGACTCTGCAGCAGAGATTCAACTACTAGGGAGACAG CATTGGAAAACATTAGGCAAACCATTTTGAGGAAAACCGAGTATCTTCGTTCGGTGAAAGAAACACCTCA TCGTCCATCAGACGGGCTTTCAAATACCGAGTCTTCGGATGGGTTGAATAAGCTACTTGCTCATCTGCTT ATGCTTTCTAAGAGGTGTCCCTTCAAAGATGTGAGAGAGAAAAGTGAGTTTATTCTGAAGAGCATCCAGG AACTTGGCATTAGAATTCCTCGACCACTAGGACAGGGACCAAGCAGATTCATCCCAGAAAAGGAGATCCT CCAAGTGGGGAGTGAAGACGCACAGATGCATGCTTTATTTGCAGATTCTTTTGCTGCTTTGGGCCGTTTG GATAACATTACGTTAGTGATGGTTTTCCACCCACAATATTTAGAAAGTTTCTTAAAAACTCAGCACTATC TACTGCAAATGGATGGGCCGTTACCCCTACATTATCGTCACTACATTGGAATAATGGCTGCGGCAAGACA TCAGTGCTCCTACTTAGTGAACCTGCATGTAAATGATTTCCTTCATGTTGGTGGGGACCCCAAGTGGCTC AATGGTTTAGAGAATGCTCCTCAAAAACTACAGAATTTAGGAGAACTTAACAAAGTGTTAGCCCATAGAC CTTGGCTTATTACCAAAGAACACATTGAGGGACTTTTAAAAGCTGAAGAGCACAGCTGGTCCCTTGCGGA ATTGGTACATGCAGTAGTTTTACTCACACACTATCATTCTCTTGCCTCATTCACATTCGGCTGTGGAATC AGTCCAGAAATTCATTGTGATGGTGGCCACACATTCAGACCTCCTTCTGTTAGCAACTACTGCATCTGTG ACATTACAAATGGCAATCACAGTGTGGATGAGATGCCGGTCAACTCAGCAGAAAATGTTTCTGTAAGTGA TTCTTTCTTTGAGGTTGAAGCCCTCATGGAAAAGATGAGGCAGTTACAGGAATGTCGAGATGAAGAAGAG GCAAGTCAGGAAGAGATGGCTTCACGTTTTGAAATAGAAAAAAGAGAGAGTATGTTTGTCTTCTCTTCAG ATGATGAAGAAGTTACACCAGCAAGAGCTGTATCTCGTCATTTTGAGGATACTAGTTATGGCTATAAAGA TTTCTCTAGACATGGGATGCATGTTCCAACATTTCGTGTCCAGGACTATTGCTGGGAAGATCATGGTTAT TCTTTGGTAAATCGCCTTTATCCAGATGTGGGACAGTTGATTGATGAAAAATTTCACATTGCTTACAATC TTACTTATAATACAATGGCAATGCACAAAGATGTTGATACCTCAATGCTTAGACGGGCAATTTGGAACTA TATTCACTGCATGTTTGGAATAAGATATGATGATTATGACTATGGTGAAATTAACCAGCTATTGGATCGT AGCTTTAAAGTTTATATCAAAACTGTTGTTTGCACTCCTGAAAAGGTTACCAAAAGAATGTATGATAGCT TCTGGAGGCAGTTCAAGCACTCTGAGAAGGTTCATGTTAATCTGCTTCTTATAGAAGCTAGGATGCAAGC AGAACTCCTTTATGCTCTGAGAGCCATTACCCGCTATATGACC ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA >RG211305 representing NM_014454
Red=Cloning site Green=Tags(s) MAEGENEVRWDGLCSRDSTTRETALENIRQTILRKTEYLRSVKETPHRPSDGLSNTESSDGLNKLLAHLL MLSKRCPFKDVREKSEFILKSIQELGIRIPRPLGQGPSRFIPEKEILQVGSEDAQMHALFADSFAALGRL DNITLVMVFHPQYLESFLKTQHYLLQMDGPLPLHYRHYIGIMAAARHQCSYLVNLHVNDFLHVGGDPKWL NGLENAPQKLQNLGELNKVLAHRPWLITKEHIEGLLKAEEHSWSLAELVHAVVLLTHYHSLASFTFGCGI SPEIHCDGGHTFRPPSVSNYCICDITNGNHSVDEMPVNSAENVSVSDSFFEVEALMEKMRQLQECRDEEE ASQEEMASRFEIEKRESMFVFSSDDEEVTPARAVSRHFEDTSYGYKDFSRHGMHVPTFRVQDYCWEDHGY SLVNRLYPDVGQLIDEKFHIAYNLTYNTMAMHKDVDTSMLRRAIWNYIHCMFGIRYDDYDYGEINQLLDR SFKVYIKTVVCTPEKVTKRMYDSFWRQFKHSEKVHVNLLLIEARMQAELLYALRAITRYMT TRTRRLE - GFP Tag - V |
Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
![]() |
ACCN | NM_014454 |
ORF Size | 1653 bp |
OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_014454.1, NP_055269.1 |
RefSeq Size | 3212 |
RefSeq ORF | 1656 |
Locus ID | 27244 |
Domains | PA26 |
Protein Pathways | p53 signaling pathway |
Gene Summary | This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
SC127795 | SESN1 (untagged)-Human sestrin 1 (SESN1), transcript variant 1 |
USD 930.00 |
|
RC211305 | SESN1 (Myc-DDK-tagged)-Human sestrin 1 (SESN1), transcript variant 1 |
USD 500.00 |
|
RC211305L3 | Lenti-ORF clone of SESN1 (Myc-DDK-tagged)-Human sestrin 1 (SESN1), transcript variant 1 |
USD 700.00 |
|
RC211305L4 | Lenti-ORF clone of SESN1 (mGFP-tagged)-Human sestrin 1 (SESN1), transcript variant 1 |
USD 700.00 |
{0} Product Review(s)
Be the first one to submit a review