IL9R (NM_002186) Human Tagged ORF Clone

CAT#: RG212084

IL9R (GFP-tagged) - Human interleukin 9 receptor (IL9R), transcript variant 1

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: TurboGFP
• Symbol: IL9R
• Synonyms: CD129; IL-9R
• Vector: pCMV6-AC-GFP
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RG212084 representing NM_002186
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGGACTGGGCAGATGCATCTGGGAAGGCTGGACCTTGGAGAGTGAGGCCCTGAGGCGAGACATGGGCA
  CCTGGCTCCTGGCCTGCATCTGCATCTGCACCTGTGTCTGCTTGGGAGTCTCTGTCACAGGGGAAGGACA
  AGGGCCAAGGTCTAGAACCTTCACCTGCCTCACCAACAACATTCTCAGGATCGATTGCCACTGGTCTGCC
  CCAGAGCTGGGACAGGGCTCCAGCCCCTGGCTCCTCTTCACCAGCAACCAGGCTCCTGGCGGCACACATA
  AGTGCATCTTGCGGGGCAGTGAGTGCACCGTCGTGCTGCCACCTGAGGCAGTGCTCGTGCCATCTGACAA
  TTTCACCATCACTTTCCACCACTGCATGTCTGGGAGGGAGCAGGTCAGCCTGGTGGACCCGGAGTACCTG
  CCCCGGAGACACGTTAAGCTGGACCCGCCCTCTGACTTGCAGAGCAACATCAGTTCTGGCCACTGCATCC
  TGACCTGGAGCATCAGTCCTGCCTTGGAGCCAATGACCACACTTCTCAGCTATGAGCTGGCCTTCAAGAA
  GCAGGAAGAGGCCTGGGAGCAGGCCCAGCACAGGGATCACATTGTCGGGGTGACCTGGCTTATACTTGAA
  GCCTTTGAGCTGGACCCTGGCTTTATCCATGAGGCCAGGCTGCGTGTCCAGATGGCCACACTGGAGGATG
  ATGTGGTAGAGGAGGAGCGTTATACAGGCCAGTGGAGTGAGTGGAGCCAGCCTGTGTGCTTCCAGGCTCC
  CCAGAGACAAGGCCCTCTGATCCCACCCTGGGGGTGGCCAGGCAACACCCTTGTTGCTGTGTCCATCTTT
  CTCCTGCTGACTGGCCCGACCTACCTCCTGTTCAAGCTGTCGCCCAGGGTGAAGAGAATCTTCTACCAGA
  ACGTGCCCTCTCCAGCGATGTTCTTCCAGCCCCTCTACAGTGTACACAATGGGAACTTCCAGACTTGGAT
  GGGGGCCCACGGGGCCGGTGTGCTGTTGAGCCAGGACTGTGCTGGCACCCCACAGGGAGCCTTGGAGCCC
  TGCGTCCAGGAGGCCACTGCACTGCTCACTTGTGGCCCAGCGCGTCCTTGGAAATCTGTGGCCCTGGAGG
  AGGAACAGGAGGGCCCTGGGACCAGGCTCCCGGGGAACCTGAGCTCAGAGGATGTGCTGCCAGCAGGGTG
  TACGGAGTGGAGGGTACAGACGCTTGCCTATCTGCCACAGGAGGACTGGGCCCCCACGTCCCTGACTAGG
  CCGGCTCCCCCAGACTCAGAGGGCAGCAGGAGCAGCAGCAGCAGCAGCAGCAGCAACAACAACAACTACT
  GTGCCTTGGGCTGCTATGGGGGATGGCACCTCTCAGCCCTCCCAGGAAACACACAGAGCTCTGGGCCCAT
  CCCAGCCCTGGCCTGTGGCCTTTCTTGTGACCATCAGGGCCTGGAGACCCAGCAAGGAGTTGCCTGGGTG
  CTGGCTGGTCACTGCCAGAGGCCTGGGCTGCATGAGGACCTCCAGGGCATGTTGCTCCCTTCTGTCCTCA
  GCAAGGCTCGGTCCTGGACATTC
  
  ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA
  Protein Sequence

  >RG212084 representing NM_002186
  Red=Cloning site Green=Tags(s)
  
  MGLGRCIWEGWTLESEALRRDMGTWLLACICICTCVCLGVSVTGEGQGPRSRTFTCLTNNILRIDCHWSA
  PELGQGSSPWLLFTSNQAPGGTHKCILRGSECTVVLPPEAVLVPSDNFTITFHHCMSGREQVSLVDPEYL
  PRRHVKLDPPSDLQSNISSGHCILTWSISPALEPMTTLLSYELAFKKQEEAWEQAQHRDHIVGVTWLILE
  AFELDPGFIHEARLRVQMATLEDDVVEEERYTGQWSEWSQPVCFQAPQRQGPLIPPWGWPGNTLVAVSIF
  LLLTGPTYLLFKLSPRVKRIFYQNVPSPAMFFQPLYSVHNGNFQTWMGAHGAGVLLSQDCAGTPQGALEP
  CVQEATALLTCGPARPWKSVALEEEQEGPGTRLPGNLSSEDVLPAGCTEWRVQTLAYLPQEDWAPTSLTR
  PAPPDSEGSRSSSSSSSSNNNNYCALGCYGGWHLSALPGNTQSSGPIPALACGLSCDHQGLETQQGVAWV
  LAGHCQRPGLHEDLQGMLLPSVLSKARSWTF
  
  TRTRRLE - GFP Tag - V
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_002186
• ORF Size: 1563 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_002186.2, NP_002177.2
• RefSeq Size: 2171
• RefSeq ORF: 1566
• Locus ID: 3581
• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway
• Gene Summary: The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]