KCNH4 (NM_012285) Human Tagged ORF Clone

CAT#: RG212999

KCNH4 (GFP-tagged) - Human potassium voltage-gated channel, subfamily H (eag-related), member 4 (KCNH4)

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: TurboGFP
• Symbol: KCNH4
• Synonyms: BEC2; ELK1; Kv12.3
• Vector: pCMV6-AC-GFP
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RG212999 representing NM_012285
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGCCGGTCATGAAGGGGTTGCTGGCCCCGCAAAACACCTTCCTGGACACCATCGCCACCCGTTTTGACG
  GAACGCACAGCAACTTCCTGCTGGCCAACGCACAGGGCACACGGGGCTTTCCCATCGTCTACTGCTCCGA
  CGGCTTCTGCGAGCTCACAGGCTACGGTCGCACCGAGGTCATGCAGAAGACCTGCAGCTGCCGTTTCCTC
  TACGGCCCAGAGACCAGTGAGCCAGCCCTGCAGCGTCTGCACAAAGCCCTGGAGGGCCACCAGGAGCACC
  GGGCTGAAATCTGCTTCTACCGCAAGGATGGCTCAGCCTTTTGGTGCCTCCTGGACATGATGCCCATCAA
  GAATGAGATGGGGGAGGTCGTGCTGTTCCTCTTTTCCTTCAAGGATATCACTCAGAGTGGAAGCCCAGGA
  CTTGGCCCCCAAGGAGGCCGCGGGGACAGTAATCACGAAAACTCCCTTGGTAGAAGGGGAGCCACCTGGA
  AATTTCGGTCTGCCAGAAGACGGAGCCGTACTGTCCTACACCGACTGACCGGCCACTTTGGCCGCCGGGG
  CCAGGGAGGCATGAAGGCCAATAATAACGTGTTTGAGCCAAAGCCATCAGTGCCCGAGTACAAGGTGGCC
  TCCGTGGGGGGGTCTCGCTGCCTCCTCCTCCACTACAGCGTCTCCAAGGCCATCTGGGACGGCCTTATCC
  TCCTTGCCACCTTCTACGTTGCGGTCACCGTCCCCTACAATGTCTGTTTCTCGGGTGACGATGACACCCC
  CATCACTTCGCGACACACCCTTGTCAGCGACATCGCCGTGGAAATGCTCTTCATCCTAGATATCATCCTG
  AACTTCCGCACCACCTATGTGTCCCAGTCCGGCCAGGTAATCTCTGCTCCTCGTTCCATTGGCCTCCACT
  ACCTGGCCACCTGGTTCTTCATCGACCTTATTGCTGCTCTGCCCTTTGACCTGCTTTACATCTTCAACAT
  CACCGTGACCTCGCTGGTGCACCTACTGAAGACAGTGCGGCTGTTGCGGCTGCTGCGGCTGCTGCAGAAG
  CTGGAGCGGTACTCTCAGTGCAGTGCTGTGGTGCTCACGCTGCTCATGTCGGTCTTTGCGCTCCTTGCCC
  ACTGGATGGCCTGCATCTGGTATGTCATCGGGCGCCGGGAGATGGAGGCCAATGACCCGCTGCTCTGGGA
  CATTGGCTGGTTGCATGAGTTGGGCAAGCGTCTGGAGGTGCCCTATGTCAATGGCTCGGTGGGCGGCCCA
  TCACGGCGCAGCGCCTACATCGCGGCACTGTACTTCACTCTAAGCAGCCTCACCAGTGTGGGCTTTGGCA
  ACGTGTGTGCCAACACCGACGCGGAGAAGATCTTCTCCATCTGCACGATGCTCATAGGCGCCCTGATGCA
  CGCTGTGGTGTTCGGGAACGTGACAGCCATCATCCAGCGCATGTACTCGCGCCGCTCGCTCTACCACAGC
  CGCATGAAGGACCTCAAGGACTTCATCCGTGTGCACCGCCTGCCGCGGCCGCTCAAGCAGCGCATGCTCG
  AATACTTCCAGACCACGTGGGCCGTCAACAGCGGCATCGACGCCAACGAGTTACTGCGTGACTTCCCAGA
  CGAGCTGAGAGCTGACATTGCTATGCACCTGAATCGGGAGATCCTGCAGCTGCCGTTGTTCGGGGCAGCG
  AGCAGGGGCTGCCTGCGGGCCCTATCGCTGCACATCAAGACCTCGTTCTGCGCTCCGGGCGAGTACCTGT
  TGCGCCGTGGGGATGCCCTGCAGGCACATTACTATGTCTGCTCCGGCTCGCTTGAGGTGCTCCGAGACAA
  CATGGTGCTGGCCATCCTGGGGAAGGGGGACCTGATTGGAGCAGATATCCCTGAGCCGGGGCAGGAGCCT
  GGGTTGGGAGCAGACCCAAACTTCGTGCTAAAGACCAGTGCTGATGTGAAAGCTCTGACCTACTGTGGCC
  TGCAGCAGCTGAGCAGCCGAGGGCTGGCTGAGGTCCTGAGGCTCTATCCTGAGTATGGGGCTGCCTTCCG
  GGCTGGCCTGCCCCGGGACCTCACCTTCAACCTGCGCCAGGGCTCTGACACCAGTGGCCTCAGCCGCTTT
  TCCCGATCCCCTCGCCTCTCCCAGCCCCGCTCAGAAAGCCTCGGCTCCTCCTCAGACAAGACGCTGCCAT
  CCATCACAGAGGCCGAGAGTGGCGCGGAGCCTGGGGGTGGTCCCAGGCCCCGACGGCCCCTCCTGCTGCC
  CAACCTCAGCCCAGCACGGCCTCGGGGCTCCCTGGTCAGCCTTTTGGGCGAGGAGCTGCCCCCATTCTCA
  GCCCTTGTCTCCTCTCCTTCCTTATCCCCATCCCTGTCCCCTGCCCTGGCTGGCCAGGGCCACAGTGCCT
  CCCCTCACGGCCCCCCCAGGTGCTCTGCTGCCTGGAAGCCCCCTCAGCTTCTCATTCCCCCACTGGGAAC
  CTTTGGACCTCCGGACCTCAGTCCCCGGATAGTGGATGGCATTGAGGACTCTGGCAGCACAGCTGAGGCC
  CCTTCATTCCGATTCAGCAGGAGGCCTGAACTGCCAAGGCCCCGCTCCCAGGCGCCCCCTACAGGGACCA
  GGCCCAGCCCAGAATTGGCCAGTGAGGCTGAGGAGGTGAAGGAAAAGGTTTGCCGGCTGAACCAGGAGAT
  CTCTCGTCTCAATCAGGAGGTGTCTCAGCTTAGCCGGGAGCTGCGGCACATCATGGGCCTGCTGCAGGCC
  AGGCTGGGTCCCCCAGGCCACCCAGCAGGCTCCGCTTGGACCCCAGACCCTCCTTGTCCACAGCTGAGGC
  CACCATGCCTCTCTCCTTGTGCGTCCAGACCACCACCCAGCCTCCAGGATACTACGCTTGCTGAAGTTCA
  CTGCCCAGCCAGTGTGGGGACCATGGAGACAGGGACTGCGCTCCTGGACTTGAGACCTTCCATATTGCCC
  CCCTACCCCTCAGAGCCTGACCCTCTGGGACCCTCTCCAGTGCCAGAGGCCTCACCCCCAACCCCAAGCC
  TCTTGAGGCACAGTTTCCAGTCCAGGTCAGACACGTTCCAC
  
  ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA
  Protein Sequence

  >RG212999 representing NM_012285
  Red=Cloning site Green=Tags(s)
  
  MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEVMQKTCSCRFL
  YGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEMGEVVLFLFSFKDITQSGSPG
  LGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLTGHFGRRGQGGMKANNNVFEPKPSVPEYKVA
  SVGGSRCLLLHYSVSKAIWDGLILLATFYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIIL
  NFRTTYVSQSGQVISAPRSIGLHYLATWFFIDLIAALPFDLLYIFNITVTSLVHLLKTVRLLRLLRLLQK
  LERYSQCSAVVLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGP
  SRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHS
  RMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREILQLPLFGAA
  SRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILGKGDLIGADIPEPGQEP
  GLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAFRAGLPRDLTFNLRQGSDTSGLSRF
  SRSPRLSQPRSESLGSSSDKTLPSITEAESGAEPGGGPRPRRPLLLPNLSPARPRGSLVSLLGEELPPFS
  ALVSSPSLSPSLSPALAGQGHSASPHGPPRCSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGSTAEA
  PSFRFSRRPELPRPRSQAPPTGTRPSPELASEAEEVKEKVCRLNQEISRLNQEVSQLSRELRHIMGLLQA
  RLGPPGHPAGSAWTPDPPCPQLRPPCLSPCASRPPPSLQDTTLAEVHCPASVGTMETGTALLDLRPSILP
  PYPSEPDPLGPSPVPEASPPTPSLLRHSFQSRSDTFH
  
  TRTRRLE - GFP Tag - V
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_012285
• ORF Size: 3051 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_012285.1, NP_036417.1
• RefSeq Size: 3920
• RefSeq ORF: 3054
• Locus ID: 23415
• Protein Families: Druggable Genome, Ion Channels: Potassium, Transmembrane
• Gene Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. The gene is brain-specific, and located in the neocortex and the striatum. It may be involved in cellular excitability of restricted neurons in the central nervous system. [provided by RefSeq, Jul 2008]