SOCS5 (NM_014011) Human Tagged ORF Clone

CAT#: RG214950

SOCS5 (GFP-tagged) - Human suppressor of cytokine signaling 5 (SOCS5), transcript variant 1

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: TurboGFP
• Symbol: SOCS5
• Synonyms: CIS6; Cish5; CISH6; SOCS-5
• Vector: pCMV6-AC-GFP
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RG214950 representing NM_014011
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGATAAAGTGGGAAAAATGTGGAATAACTTCAAATACAGGTGTCAGAATCTCTTCGGTCATGAGGGAG
  GAAGCCGTAGTGAAAATGTGGACATGAACTCCAACAGATGTTTGTCTGTCAAAGAGAAAAACATCAGCAT
  AGGAGACTCAACTCCTCAGCAACAAAGCAGTCCCTTAAGAGAAAATATTGCCTTACAACTGGGATTAAGC
  CCTTCGAAGAATTCTTCAAGGAGAAATCAAAATTGTGCCACAGAAATCCCTCAAATTGTTGAAATAAGCA
  TCGAAAAGGATAATGATTCTTGTGTTACCCCAGGAACAAGACTTGCACGAAGAGATTCCTACTCTCGACA
  TGCTCCATGGGGTGGGAAGAAAAAACATTCCTGTTCTACAAAGACCCAGAGTTCATTGGATGCTGATAAA
  AAGTTTGGTAGAACTCGAAGTGGACTTCAAAGGAGAGAGAGGCGCTACGGCGTAAGTTCTGTACACGACA
  TGGACAGTGTTTCCAGCAGAACTGTAGGAAGTCGCTCTCTAAGACAGAGGTTGCAGGATACTGTGGGCTT
  GTGTTTTCCCATGAGAACTTACAGCAAGCAGTCAAAGCCTCTCTTTTCCAATAAAAGAAAAATCCATCTC
  TCTGAATTAATGCTTGAGAAATGCCCTTTTCCTGCTGGCTCAGATTTAGCCCAAAAATGGCATTTGATTA
  AACAGCATACAGCTCCTGTGAGCCCACATTCAACATTTTTTGATACATTTGATCCATCTTTGGTTTCTAC
  AGAAGATGAAGAAGATAGGCTTAGAGAGAGAAGGCGGCTTAGTATTGAAGAAGGGGTTGATCCCCCTCCC
  AATGCACAAATACATACATTTGAAGCTACTGCACAGGTTAATCCATTATATAAACTGGGACCAAAATTAG
  CTCCTGGAATGACTGAAATAAGTGGGGACAGTTCTGCAATTCCACAAGCTAATTGTGACTCGGAAGAGGA
  TACAACCACCCTGTGTTTGCAGTCACGGAGGCAGAAGCAGCGTCAGATATCTGGAGACAGCCATACCCAT
  GTTAGCAGACAGGGAGCTTGGAAAGTCCACACACAGATTGATTACATACACTGCCTCGTGCCTGATTTGC
  TTCAAATTACAGGGAATCCCTGTTACTGGGGAGTGATGGACCGTTATGAAGCAGAAGCCCTTCTCGAAGG
  GAAACCTGAAGGCACGTTTTTGCTCAGGGACTCTGCGCAAGAGGACTACCTCTTCTCTGTGAGCTTCCGC
  CGCTACAACAGATCCCTGCATGCCCGAATTGAGCAGTGGAATCACAACTTTAGTTTCGACGCCCATGACC
  CGTGTGTATTTCACTCCTCCACTGTAACGGGACTTTTAGAACATTATAAAGATCCCAGTTCGTGCATGTT
  TTTTGAACCATTGCTTACTATATCACTAAATAGGACTTTCCCTTTTAGCCTGCAGTATATCTGTCGCGCG
  GTAATCTGCAGGTGCACTACGTATGATGGAATTGATGGGCTCCCTCTACCCTCAATGTTACAGGATTTTT
  TAAAAGAGTATCATTATAAACAAAAAGTTAGAGTTCGCTGGTTGGAACGAGAACCAGTCAAGGCAAAG
  
  ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA
  Protein Sequence

  >RG214950 representing NM_014011
  Red=Cloning site Green=Tags(s)
  
  MDKVGKMWNNFKYRCQNLFGHEGGSRSENVDMNSNRCLSVKEKNISIGDSTPQQQSSPLRENIALQLGLS
  PSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPWGGKKKHSCSTKTQSSLDADK
  KFGRTRSGLQRRERRYGVSSVHDMDSVSSRTVGSRSLRQRLQDTVGLCFPMRTYSKQSKPLFSNKRKIHL
  SELMLEKCPFPAGSDLAQKWHLIKQHTAPVSPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPP
  NAQIHTFEATAQVNPLYKLGPKLAPGMTEISGDSSAIPQANCDSEEDTTTLCLQSRRQKQRQISGDSHTH
  VSRQGAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFR
  RYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRA
  VICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREPVKAK
  
  TRTRRLE - GFP Tag - V
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_014011
• ORF Size: 1608 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_014011.4, NP_054730.1
• RefSeq Size: 4422
• RefSeq ORF: 1611
• Locus ID: 9655
• Domains: SH2, SOCS
• Protein Families: Druggable Genome
• Protein Pathways: Jak-STAT signaling pathway
• Gene Summary: The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]