TRIF (TICAM1) (NM_182919) Human Tagged ORF Clone

CAT#: RG217522

TICAM1 (GFP-tagged) - Human toll-like receptor adaptor molecule 1 (TICAM1)

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: TurboGFP
• Symbol: TICAM1
• Synonyms: IIAE6; MyD88-3; PRVTIRB; TICAM-1; TRIF
• Vector: pCMV6-AC-GFP
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RG217522 representing NM_182919
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGCCTGCACGGGCCCATCACTTCCTAGCGCCTTCGACATTCTAGGTGCAGCAGGCCAGGACAAGCTCT
  TGTATCTGAAGCACAAACTGAAGACCCCACGCCCAGGCTGCCAGGGGCAGGACCTCCTGCATGCCATGGT
  TCTCCTGAAGCTGGGCCAGGAAACTGAGGCCAGGATCTCTCTAGAGGCATTGAAGGCCGATGCGGTGGCC
  CGGCTGGTGGCCCGCCAGTGGGCTGGCGTGGACAGCACCGAGGACCCAGAGGAGCCCCCAGATGTGTCCT
  GGGCTGTGGCCCGCTTGTACCACCTGCTGGCTGAGGAGAAGCTGTGCCCCGCCTCGCTGCGGGACGTGGC
  CTACCAGGAAGCCGTCCGCACCCTCAGCTCCAGGGACGACCACCGGCTGGGGGAACTTCAGGATGAGGCC
  CGAAACCGGTGTGGGTGGGACATTGCTGGGGATCCAGGGAGCATCCGGACGCTCCAGTCCAATCTGGGCT
  GCCTCCCACCATCCTCGGCTTTGCCCTTTGGGACCAGGAGCCTCCCACGCCCCATTGACGGTGTTTCGGA
  CTGGAGCCAAGGGTGCTCCCTGCGATCCACTGGCAGCCCTGCCTCCCTGGCCAGCAACTTGGAAATCAGC
  CAGTCCCCTACCATGCCCTTCCTCAGCCTGCACCGCAGCCCACATGGGCCCAGCAAGCTCTGTGACGACC
  CCCAGGCCAGCTTGGTGCCCGAGCCTGTCCCCGGTGGCTGCCAGGAGCCTGAGGAGATGAGCTGGCCGCC
  ATCGGGGGAGATTGCCAGCCCACCAGAGCTGCCAAGCAGCCCACCTCCTGGGCTTCCCGAAGTGGCCCCA
  GATGCAACCTCCACTGGCCTCCCTGATACCCCCGCAGCTCCAGAAACCAGCACCAACTACCCAGTGGAGT
  GCACCGAGGGGTCTGCAGGCCCCCAGTCTCTCCCCTTGCCTATTCTGGAGCCGGTCAAAAACCCCTGCTC
  TGTCAAAGACCAGACGCCACTCCAACTTTCTGTAGAAGATACCACCTCTCCAAATACCAAGCCGTGCCCA
  CCTACTCCCACCACCCCAGAAACATCCCCTCCTCCTCCTCCTCCTCCTCCTTCATCTACTCCTTGTTCAG
  CTCACCTGACCCCCTCCTCCCTGTTCCCTTCCTCCCTGGAATCATCATCGGAACAGAAATTCTATAACTT
  TGTGATCCTCCACGCCAGGGCAGACGAACACATCGCCCTGCGGGTTCGGGAGAAGCTGGAGGCCCTTGGC
  GTGCCCGACGGGGCCACCTTCTGCGAGGATTTCCAGGTGCCGGGGCGCGGGGAGCTGAGCTGCCTGCAGG
  ACGCCATAGACCACTCAGCTTTCATCATCCTACTTCTCACCTCCAACTTCGACTGTCGCCTGAGCCTGCA
  CCAGGTGAACCAAGCCATGATGAGCAACCTCACGCGACAGGGGTCGCCAGACTGTGTCATCCCCTTCCTG
  CCCCTGGAGAGCTCCCCGGCCCAGCTCAGCTCCGACACGGCCAGCCTGCTCTCCGGGCTGGTGCGGCTGG
  ACGAACACTCCCAGATCTTCGCCAGGAAGGTGGCCAACACCTTCAAGCCCCACAGGCTTCAGGCCCGAAA
  GGCCATGTGGAGGAAGGAACAGGACACCCGAGCCCTGCGGGAACAGAGCCAACACCTGGATGGTGAGCGG
  ATGCAGGCGGCGGCACTGAACGCAGCCTACTCAGCCTACCTCCAGAGCTACTTGTCCTACCAGGCACAGA
  TGGAGCAGCTCCAGGTGGCTTTTGGGAGCCACATGTCATTTGGGACTGGGGCGCCCTATGGGGCTCGAAT
  GCCCTTTGGGGGCCAGGTGCCCCTGGGAGCCCCGCCACCCTTTCCCACTTGGCCGGGGTGCCCGCAGCCG
  CCACCCCTGCACGCATGGCAGGCTGGCACCCCCCCACCGCCCTCCCCACAGCCAGCAGCCTTTCCACAGT
  CACTGCCCTTCCCGCAGTCCCCAGCCTTCCCTACGGCCTCACCCGCACCCCCTCAGAGCCCAGGGCTGCA
  ACCCCTCATTATCCACCACGCACAGATGGTACAGCTGGGGCTGAACAACCACATGTGGAACCAGAGAGGG
  TCCCAGGCGCCCGAGGACAAGACGCAGGAGGCAGAA
  
  ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA
  Protein Sequence

  >RG217522 representing NM_182919
  Red=Cloning site Green=Tags(s)
  
  MACTGPSLPSAFDILGAAGQDKLLYLKHKLKTPRPGCQGQDLLHAMVLLKLGQETEARISLEALKADAVA
  RLVARQWAGVDSTEDPEEPPDVSWAVARLYHLLAEEKLCPASLRDVAYQEAVRTLSSRDDHRLGELQDEA
  RNRCGWDIAGDPGSIRTLQSNLGCLPPSSALPFGTRSLPRPIDGVSDWSQGCSLRSTGSPASLASNLEIS
  QSPTMPFLSLHRSPHGPSKLCDDPQASLVPEPVPGGCQEPEEMSWPPSGEIASPPELPSSPPPGLPEVAP
  DATSTGLPDTPAAPETSTNYPVECTEGSAGPQSLPLPILEPVKNPCSVKDQTPLQLSVEDTTSPNTKPCP
  PTPTTPETSPPPPPPPPSSTPCSAHLTPSSLFPSSLESSSEQKFYNFVILHARADEHIALRVREKLEALG
  VPDGATFCEDFQVPGRGELSCLQDAIDHSAFIILLLTSNFDCRLSLHQVNQAMMSNLTRQGSPDCVIPFL
  PLESSPAQLSSDTASLLSGLVRLDEHSQIFARKVANTFKPHRLQARKAMWRKEQDTRALREQSQHLDGER
  MQAAALNAAYSAYLQSYLSYQAQMEQLQVAFGSHMSFGTGAPYGARMPFGGQVPLGAPPPFPTWPGCPQP
  PPLHAWQAGTPPPPSPQPAAFPQSLPFPQSPAFPTASPAPPQSPGLQPLIIHHAQMVQLGLNNHMWNQRG
  SQAPEDKTQEAE
  
  TRTRRLE - GFP Tag - V
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_182919
• ORF Size: 2136 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_182919.1, NP_891549.1
• RefSeq Size: 2460
• RefSeq ORF: 2139
• Locus ID: 148022
• Protein Families: Druggable Genome
• Protein Pathways: Toll-like receptor signaling pathway
• Gene Summary: This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012]