ADAM19 (NM_033274) Human Tagged ORF Clone

CAT#: RG222510

ADAM19 (GFP-tagged) - Human ADAM metallopeptidase domain 19 (ADAM19)

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: TurboGFP
• Symbol: ADAM19
• Synonyms: FKSG34; MADDAM; MLTNB
• Vector: pCMV6-AC-GFP
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RG222510 representing NM_033274
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGCCAGGGGGCGCAGGCGCCGCCCGGCTCTGCTTGCTGGCGTTTGCCCTGCAGCCCCTCCGGCCGCGGG
  CGGCGCGGGAGCCTGGATGGACAAGAGGAAGTGAGGAAGGCAGCCCCAAGCTGCAGCATGAACTTATCAT
  ACCTCAGTGGAAGACTTCAGAAAGCCCCGTGAGAGAAAAGCATCCACTCAAAGCTGAGCTCAGGGTAATG
  GCTGAGGGGCGAGAACTGATCCTGGACCTGGAGAAGAATGAGCAACTTTTTGCTCCTTCCTACACAGAAA
  CCCATTATACTTCAAGTGGTAACCCTCAAACCACCACACGGAAATTGGAGGATCACTGCTTTTACCACGG
  CACGGTGAGGGAGACAGAACTGTCCAGCGTCACGCTCAGCACTTGCCGAGGAATTAGAGGACTGATTACG
  GTGAGCAGCAACCTCAGCTACGTCATCGAGCCCCTCCCTGACAGCAAGGGCCAACACCTTATTTACAGAT
  CTGAACATCTCAAGCCGCCCCCGGGAAACTGTGGGTTCGAGCACTCCAAGCCCACCACCAGGGACTGGGC
  TCTTCAGTTTACACAACAGACCAAGAAGCGACCTCGCAGGATGAAAAGGGAAGATTTAAACTCCATGAAG
  TATGTGGAGCTTTACCTCGTGGCTGATTATTTAGAGTTTCAGAAGAATCGACGAGACCAGGACGCCACCA
  AACACAAGCTCATAGAGATCGCCAACTATGTTGATAAGTTTTACCGATCCTTGAACATCCGGATTGCTCT
  CGTGGGCTTGGAAGTGTGGACCCACGGGAACATGTGTGAAGTTTCAGAGAATCCATATTCTACCCTCTGG
  TCCTTTCTCAGTTGGAGGCGCAAGCTGCTTGCCCAGAAGTACCATGACAACGCCCAATTAATCACGGGCA
  TGTCCTTCCACGGCACCACCATCGGCCTGGCCCCCCTCATGGCCATGTGCTCTGTGTACCAGTCTGGAGG
  AGTCAACATGGACCACTCCGAGAATGCCATTGGCGTGGCTGCCACCATGGCCCACGAGATGGGCCACAAC
  TTTGGCATGACCCATGATTCTGCAGATTGCTGCTCGGCCAGTGCGGCTGATGGTGGGTGCATCATGGCAG
  CTGCCACTGGGCACCCCTTTCCCAAAGTGTTCAATGGATGCAACAGGAGGGAGCTGGACAGGTATCTGCA
  GTCAGGTGGTGGAATGTGTCTCTCCAACATGCCAGACACCAGGATGTTGTATGGAGGCCGGAGGTGTGGG
  AACGGGTATCTGGAAGATGGGGAAGAGTGTGACTGTGGAGAAGAAGAGGAATGTAACAACCCCTGCTGCA
  ATGCCTCTAATTGTACCCTGAGGCCGGGGGCGGAGTGTGCTCACGGCTCCTGCTGCCACCAGTGTAAGCT
  GTTGGCTCCTGGGACCCTGTGCCGCGAGCAGGCCAGGCAGTGTGACCTCCCGGAGTTCTGTACGGGCAAG
  TCTCCCCACTGCCCTACCAACTTCTACCAGATGGATGGTACCCCCTGTGAGGGCGGCCAGGCCTACTGCT
  ACAACGGCATGTGCCTCACCTACCAGGAGCAGTGCCAGCAGCTGTGGGGACCCGGAGCCCGACCTGCCCC
  TGACCTCTGCTTCGAGAAGGTGAATGTGGCAGGAGACACCTTTGGAAACTGTGGAAAGGACATGAATGGT
  GAACACAGGAAGTGCAACATGAGAGATGCGAAGTGTGGGAAGATCCAGTGTCAGAGCTCTGAGGCCCGGC
  CCCTGGAGTCCAACGCGGTGCCCATTGACACCACTATCATCATGAATGGGAGGCAGATCCAGTGCCGGGG
  CACCCACGTCTACCGAGGTCCTGAGGAGGAGGGTGACATGCTGGACCCAGGGCTGGTGATGACTGGAACC
  AAGTGTGGCTACAACCATATTTGCTTTGAGGGGCAGTGCAGGAACACCTCCTTCTTTGAAACTGAAGGCT
  GTGGGAAGAAGTGCAATGACCATGGGGTCTGTAACAACAACCAGAACTGCCACTGCCTGCCGGGCTGGGC
  CCCGCCCTTCTGCAACACACCGGGCCACGGGGGCAGTATCGACAGTGGGCCTATGCCCCCTGAGAGTGTG
  GGTCCTGTGGTAGCTGGAGTGTTGGTGGCCATCTTGGTGCTGGCGGTCCTCATGCTGATGTACTACTGCT
  GCAGACAGAACAACAAACTAGGCCAACTCAAGCCCTCAGCTCTCCCTGCCAAGCTGAGGCAACAGTTCAG
  TTGTCCCTTCAGGGTTTCTCAGAACAGCGGGACTGGTCATGCCAACCCAACTTTCAAGCTGCAGACGCCC
  CAGGGCAAGCGAAAGGTGATCAACACTCCGGAAATCCTGCGGAAGCCCTCCCAGCCTCCTCCCCGGCCCC
  CTCCAGATTATCTGCGTGGTGGGTCCCCACCTGCACCACTGCCAGCTCACCTGAGCAGGGCTGCTAGGAA
  CTCCCCAGGGCCCGGGTCTCAAATAGAGAGGACGGAGTCGTCCAGGAGGCCTCCTCCAAGCCGGCCAATT
  CCCCCCGCACCAAATTGCATCGTTTCCCAGGACTTCTCCAGGCCTCGGCCGCCCCAGAAGGCACTCCCGG
  CAAACCCAGTGCCAGGCCGCAGGAGCCTCCCCAGGCCAGGAGGTGCATCCCCACTGCGGCCCCCTGGTGC
  TGGCCCTCAGCAGTCCCGGCCTCTGGCAGCACTTGCCCCAAAGTTTCCAGAATACAGATCACAGAGGGCT
  GGAGGGATGATTAGCTCGAAAATC
  
  ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA
  Protein Sequence

  >RG222510 representing NM_033274
  Red=Cloning site Green=Tags(s)
  
  MPGGAGAARLCLLAFALQPLRPRAAREPGWTRGSEEGSPKLQHELIIPQWKTSESPVREKHPLKAELRVM
  AEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVTLSTCRGIRGLIT
  VSSNLSYVIEPLPDSKGQHLIYRSEHLKPPPGNCGFEHSKPTTRDWALQFTQQTKKRPRRMKREDLNSMK
  YVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLW
  SFLSWRRKLLAQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHN
  FGMTHDSADCCSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCG
  NGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLCREQARQCDLPEFCTGK
  SPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDMNG
  EHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGT
  KCGYNHICFEGQCRNTSFFETEGCGKKCNDHGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESV
  GPVVAGVLVAILVLAVLMLMYYCCRQNNKLGQLKPSALPAKLRQQFSCPFRVSQNSGTGHANPTFKLQTP
  QGKRKVINTPEILRKPSQPPPRPPPDYLRGGSPPAPLPAHLSRAARNSPGPGSQIERTESSRRPPPSRPI
  PPAPNCIVSQDFSRPRPPQKALPANPVPGRRSLPRPGGASPLRPPGAGPQQSRPLAALAPKFPEYRSQRA
  GGMISSKI
  
  TRTRRLE - GFP Tag - V
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_033274
• ORF Size: 2754 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_033274.2, NP_150377.1
• RefSeq Size: 6466
• RefSeq ORF: 2757
• Locus ID: 8728
• Protein Families: Druggable Genome, Transmembrane
• Gene Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013]