Mortality Factor 4 like 2 (MORF4L2) (NM_001142420) Human Tagged ORF Clone

CAT#: RG226622

MORF4L2 (GFP-tagged) - Human mortality factor 4 like 2 (MORF4L2), transcript variant 4

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: TurboGFP
• Symbol: MORF4L2
• Synonyms: MORFL2; MRGX
• Vector: pCMV6-AC-GFP
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RG226622 representing NM_001142420
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGAGTTCCAGAAAGCAGGGTTCTCAACCTCGTGGACAGCAATCTGCAGAAGAAGAGAACTTCAAAAAAC
  CAACTAGAAGCAACATGCAGAGAAGTAAAATGAGAGGGGCCTCCTCAGGAAAGAAGACAGCTGGTCCACA
  GCAGAAAAATCTTGAACCAGCTCTCCCAGGAAGATGGGGTGGTCGCTCTGCAGAGAACCCCCCTTCAGGA
  TCCGTGAGGAAGACCAGAAAGAACAAGCAGAAGACTCCTGGAAACGGAGATGGTGGCAGTACCAGCGAAG
  CACCTCAGCCCCCTCGGAAGAAAAGGGCCCGGGCAGACCCCACTGTTGAAAGTGAGGAGGCGTTTAAGAA
  TAGAATGGAGGTTAAAGTGAAGATTCCTGAAGAATTAAAACCATGGCTTGTTGAGGACTGGGACTTAGTT
  ACCAGGCAGAAGCAGCTGTTTCAACTCCCTGCCAAGAAAAATGTAGATGCAATTCTGGAGGAGTATGCAA
  ATTGCAAGAAATCGCAGGGAAATGTTGATAATAAGGAATATGCGGTTAATGAAGTTGTGGCAGGAATAAA
  AGAATATTTCAATGTGATGTTGGGCACTCAGCTGCTCTACAAATTTGAGAGGCCCCAGTATGCTGAAATC
  CTCTTGGCTCACCCTGATGCTCCAATGTCCCAGGTTTATGGAGCACCACACCTACTGAGATTATTTGTAA
  GAATTGGAGCAATGTTGGCCTATACGCCCCTTGATGAGAAAAGCCTTGCATTATTGTTGGGCTATTTGCA
  TGATTTCCTAAAATATCTGGCAAAGAATTCTGCATCTCTCTTTACTGCCAGTGATTACAAAGTGGCTTCT
  GCTGAGTACCACCGCAAAGCCCTG
  
  ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA
  Protein Sequence

  >RG226622 representing NM_001142420
  Red=Cloning site Green=Tags(s)
  
  MSSRKQGSQPRGQQSAEEENFKKPTRSNMQRSKMRGASSGKKTAGPQQKNLEPALPGRWGGRSAENPPSG
  SVRKTRKNKQKTPGNGDGGSTSEAPQPPRKKRARADPTVESEEAFKNRMEVKVKIPEELKPWLVEDWDLV
  TRQKQLFQLPAKKNVDAILEEYANCKKSQGNVDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEI
  LLAHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLGYLHDFLKYLAKNSASLFTASDYKVAS
  AEYHRKAL
  
  TRTRRLE - GFP Tag - V
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_001142420
• ORF Size: 864 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001142420.1, NP_001135892.1
• RefSeq Size: 1827
• RefSeq ORF: 867
• Locus ID: 9643
• Protein Families: Transcription Factors
• Gene Summary: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones. [UniProtKB/Swiss-Prot Function]