Calcipressin 1 (RCAN1) (NM_001285391) Human Tagged ORF Clone

CAT#: RG237112

RCAN1 (GFP-tagged) - Human regulator of calcineurin 1 (RCAN1), transcript variant 5

Specifications

Product Data

• Tag: TurboGFP
• Symbol: RCAN1
• Synonyms: ADAPT78; CSP1; DSC1; DSCR1; MCIP1; RCN1
• Vector: pCMV6-AC-GFP
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RG237112 representing NM_001285391.
  Blue=ORF Red=Cloning site Green=Tag(s)
  
  GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG
  GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC
  ATGAACTCTACCGTCCGCCAGCTCCGCGTTCCTTCGCACGTGCCTCTGCGGGATCCCTCGTGGGAAAGT
  CTCAGAAATGTCCCTAAACTGAAGAAAAGCCGGGGAATGCAAGGAGAGCAAGGTCGTAGGTTGTTCCGA
  CTGCTCCTTAACGACCTGCCTGGCAGGGACCGACTACCCTGCTCCTACCCGCAGCCCCATGTGGAGCAG
  GCATCCACCAGTGCCTCCCCGCGCTTGCTAGCAGTGAACATTCCTGAAGACACTCTCCTCTCTTATCCT
  GAATCCTCGCTCCCACTGCAGAGACACTGCGCCTTCCATAGGTTCTCCAAGGCCAAATTTGAGTCCCTC
  TTTAGGACGTATGACAAGGACATCACCTTTCAGTATTTTAAGAGCTTCAAACGAGTCAGAATAAACTTC
  AGCAACCCCTTCTCCGCAGCAGATGCCAGGCTCCAGCTGCATAAGACTGAGTTTCTGGGAAAGGAAATG
  AAGTTATATTTTGCTCAGACCTTACACATAGGAAGCTCACACCTGGCTCCGCCAAATCCAGACAAGCAG
  TTTCTGATCTCCCCTCCCGCCTCTCCGCCAGTGGGATGGAAACAAGTGGAAGATGCGACCCCAGTCATA
  AACTATGATCTCTTATATGCCATCTCCAAGCTGGGGCCAGGGGAAAAGTATGAATTGCACGCAGCGACT
  GACACCACTCCCAGCGTGGTGGTCCATGTATGTGAGAGTGATCAAGAGAAGGAGGAAGAAGAGGAAATG
  GAAAGAATGAGGAGACCTAAGCCAAAAATTATCCAGACCAGGAGGCCGGAGTACACGCCGATCCACCTC
  AGC
  ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAAAC
  
  Protein Sequence

  >Peptide sequence encoded by RG237112
  Blue=ORF Red=Cloning site Green=Tag(s)
  
  MNSTVRQLRVPSHVPLRDPSWESLRNVPKLKKSRGMQGEQGRRLFRLLLNDLPGRDRLPCSYPQPHVEQ
  ASTSASPRLLAVNIPEDTLLSYPESSLPLQRHCAFHRFSKAKFESLFRTYDKDITFQYFKSFKRVRINF
  SNPFSAADARLQLHKTEFLGKEMKLYFAQTLHIGSSHLAPPNPDKQFLISPPASPPVGWKQVEDATPVI
  NYDLLYAISKLGPGEKYELHAATDTTPSVVVHVCESDQEKEEEEEMERMRRPKPKIIQTRRPEYTPIHL
  S
  TRTRPLEMESDESGLPAMEIECRITGTLNGVEFELVGGGEGTPEQGRMTNKMKSTKGALTFSPYLLSHV
  MGYGFYHFGTYPSGYENPFLHAINNGGYTNTRIEKYEDGGVLHVSFSYRYEAGRVIGDFKVMGTGFPED
  SVIFTDKIIRSNATVEHLHPMGDNDLDGSFTRTFSLRDGGYYSSVVDSHMHFKSAIHPSILQNGGPMFA
  FRRVEEDHSNTELGIVEYQHAFKTPDADAGEERV
  
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_001285391
• ORF Size: 831 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.

Reference Data

• RefSeq: NM_001285391.2, NP_001272320.2
• RefSeq Size: 2533 bp
• RefSeq ORF: 834 bp
• Locus ID: 1827
• Cytogenetics: 21q22.12
• Protein Families: Transcription Factors
• MW: 32.3 kDa
• Gene Summary: 'The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]'