UGT2A1 (NM_001301239) Human Tagged ORF Clone

CAT#: RG238494

UGT2A1 (GFP-tagged) - Human UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus (UGT2A1), transcript variant 4

Specifications

Product Data

• Tag: TurboGFP
• Symbol: UGT2A1
• Synonyms: UDPGT2A1
• Vector: pCMV6-AC-GFP
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RG238494 representing NM_001301239.
  Blue=ORF Red=Cloning site Green=Tag(s)
  
  GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG
  GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC
  ATGTTAAACAACCTTCTGCTGTTCTCCCTTCAGATAAGTCTCATAGGAACCACTCTTGGTGGGAATGTT
  TTGATTTGGCCAATGGAAGGTAGTCATTGGCTAAATGTTAAGATAATTATAGATGAGCTCATTAAAAAG
  GAGCATAATGTGACTGTCCTAGTTGCCTCTGGTGCACTTTTCATCACACCAACCTCTAACCCATCTCTG
  ACATTTGAAATATATAAGGTGCCCTTTGGCAAAGAAAGAATAGAAGGAGTAATTAAGGACTTCGTTTTG
  ACATGGCTGGAAAATAGACCATCTCCTTCAACCATTTGGAGATTCTATCAGGAGATGGCCAAAGTAATC
  AAGGACTTCCACATGGTGTCTCAGGAGATCTGTGATGGCGTTCTTAAAAACCAACAGCTGATGGCAAAG
  CTAAAGAAAAGCAAGTTTGAAGTCCTGGTGTCTGATCCAGTATTTCCTTGTGGCGATATAGTAGCTTTA
  AAACTTGGAATTCCATTTATGTACTCCTTGAGGTTTTCTCCAGCCTCAACAGTGGAAAAGCACTGTGGG
  AAGGTACCATACCCTCCTTCCTATGTTCCTGCTGTTTTATCAGAACTCACCGACCAAATGTCTTTCACT
  GACAGAATAAGAAATTTCATCTCCTACCACCTACAGGACTACATGTTTGAAACTCTTTGGAAATCATGG
  GATTCATACTATAGTAAAGCTTTAGGAAGACCCACTACGTTATGTGAGACTATGGGGAAAGCTGAAATT
  TGGTTAATCCGAACATATTGGGATTTTGAATTTCCTCGTCCATACTTACCTAATTTTGAGTTTGTTGGA
  GGATTGCACTGCAAACCTGCCAAACCTTTACCTAAGGTTTTATGGAGATACAAAGGAAAGAAACCAGCC
  ACATTAGGAAACAATACTCAGCTCTTTGATTGGATACCCCAGAATGATCTTCTTGGACATCCCAAAACC
  AAAGCTTTTATCACTCATGGTGGAACTAATGGGATCTACGAAGCTATTTACCACGGAGTCCCTATGGTG
  GGAGTTCCCATGTTTGCTGATCAGCCTGATAACATTGCTCACATGAAGGCCAAAGGAGCAGCTGTGGAA
  GTGAACCTAAACACAATGACAAGTGTGGATTTGCTTAGCGCTTTGAGAACAGTCATTAATGAACCTTCT
  TATAAAGAGAATGCTATGAGGTTATCAAGAATTCACCATGATCAACCTGTAAAGCCCCTGGATCGAGCA
  GTCTTCTGGATCGAGTTTGTCATGCGCCACAAAGGAGCCAAGCACCTTCGGGTTGCAGCCCATGACCTC
  ACCTGGTTCCAGTACCACTCTTTGGATGTAATTGGGTTCTTGCTGGTCTGTGTGACAACGGCTATATTT
  TTGGTCATACAATGTTGTTTGTTTTCCTGTCAAAAATTTGGTAAGATAGGAAAGAAGAAAAAAAGAGAA
  ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAAAC
  
  Protein Sequence

  >Peptide sequence encoded by RG238494
  Blue=ORF Red=Cloning site Green=Tag(s)
  
  MLNNLLLFSLQISLIGTTLGGNVLIWPMEGSHWLNVKIIIDELIKKEHNVTVLVASGALFITPTSNPSL
  TFEIYKVPFGKERIEGVIKDFVLTWLENRPSPSTIWRFYQEMAKVIKDFHMVSQEICDGVLKNQQLMAK
  LKKSKFEVLVSDPVFPCGDIVALKLGIPFMYSLRFSPASTVEKHCGKVPYPPSYVPAVLSELTDQMSFT
  DRIRNFISYHLQDYMFETLWKSWDSYYSKALGRPTTLCETMGKAEIWLIRTYWDFEFPRPYLPNFEFVG
  GLHCKPAKPLPKVLWRYKGKKPATLGNNTQLFDWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHGVPMV
  GVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRLSRIHHDQPVKPLDRA
  VFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVTTAIFLVIQCCLFSCQKFGKIGKKKKRE
  TRTRPLEMESDESGLPAMEIECRITGTLNGVEFELVGGGEGTPEQGRMTNKMKSTKGALTFSPYLLSHV
  MGYGFYHFGTYPSGYENPFLHAINNGGYTNTRIEKYEDGGVLHVSFSYRYEAGRVIGDFKVMGTGFPED
  SVIFTDKIIRSNATVEHLHPMGDNDLDGSFTRTFSLRDGGYYSSVVDSHMHFKSAIHPSILQNGGPMFA
  FRRVEEDHSNTELGIVEYQHAFKTPDADAGEERV
  
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_001301239
• ORF Size: 1449 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.

Reference Data

• RefSeq: NM_001301239.1, NP_001288168.1
• RefSeq Size: 2461 bp
• RefSeq ORF: 1452 bp
• Locus ID: 10941
• Cytogenetics: 4q13.3
• Protein Families: Transmembrane
• Protein Pathways: Androgen and estrogen metabolism, Ascorbate and aldarate metabolism, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Pentose and glucuronate interconversions, Porphyrin and chlorophyll metabolism, Retinol metabolism, Starch and sucrose metabolism
• MW: 55.6 kDa
• Gene Summary: The protein encoded by this gene belongs to the UDP-glycosyltransferase family, members of which catalyze biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This enzyme is expressed in the olfactory neuroepithelium, which lines the posterior nasal cavity and is exposed to a wide range of odorants and airborne toxic compounds. Hence, this protein has been suggested to be involved in clearing lipophilic odorant molecules from the sensory epithelium. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. This gene shares exon structure with the UDP glucuronosyltransferase 2A2 family member, which encodes N-terminally distinct isoforms. [provided by RefSeq, Jul 2014]