Syngap1 (NM_181092) Rat Untagged Clone

CAT#: RN200179

Syngap1 (untagged ORF) - Rat synaptic Ras GTPase activating protein 1 homolog (rat) (Syngap1), transcript variant 1, (10 ug)

Specifications

Product Data

• Type: Rat Untagged Clone
• Tag: Tag Free
• Symbol: Syngap1
• Synonyms: Syngap
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >RN200179 representing NM_181092
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGAGCAGGTCTCGAGCCTCCATCCATCGGGGGAGCATCCCCGCGATGTCCTATGCCCCCTTCAGAGATG
  TACGGGGACCCCCTATGCACCGAACCCAATACGTTCATTCCCCGTATGACCGTCCCGGTTGGAACCCCCG
  GTTCTGCATCATCTCTGGGAACCAGCTGCTCATGCTGGATGAGGATGAGATACACCCCCTTCTGATCCGC
  GACCGGAGGAGCGAGTCCAGCCGAAACAAACTGCTGAGACGCACCGTCTCTGTGCCAGTGGAGGGGCGGC
  CCCACGGCGAGCATGAATACCACTTGGGTCGCTCGAGGAGGAAGAGTGTCCCCGGGGGGAAACAGTACAG
  CATGGAAGCCGCCCCCGCTGCGCCCTTCCGGCCCTCGCAAGGCTTCCTGAGCCGGAGGCTAAAAAGCTCC
  ATCAAACGTACAAAGTCACAACCCAAACTTGACCGGACCAGCAGCTTTCGACAGATCCTGCCTCGCTTCC
  GAAGTGCTGACCATGACCGGGCCCGGCTGATGCAGAGCTTCAAGGAGTCTCACTCCCATGAGTCCCTGCT
  GAGTCCCAGCAGTGCTGCTGAGGCCCTGGAGCTCAACCTGGATGAAGACTCCATTATCAAGCCAGTACAC
  AGCTCCATCCTGGGCCAGGAGTTCTGCTTTGAGGTAACAACATCGTCTGGGACAAAATGTTTTGCCTGTC
  GGTCTGCAGCCGAAAGGGACAAATGGATTGAGAATCTACAGAGGGCTGTGAAACCCAACAAGGACAACAG
  CCGCCGGGTAGATAACGTGCTGAAACTATGGATCATAGAAGCTCGAGAGCTGCCCCCCAAGAAGCGATAT
  TACTGCGAGTTATGCCTGGACGACATGCTCTATGCACGGACCACTTCCAAGCCCCGCTCAGCCTCAGGAG
  ACACTGTCTTTTGGGGCGAGCACTTCGAGTTTAACAACCTGCCTGCTGTCCGGGCGCTGCGGCTGCATCT
  GTACCGTGACTCGGACAAAAAGCGGAAGAAGGACAAGGCAGGCTACGTTGGCCTGGTGACTGTTCCAGTG
  GCCACCCTGGCTGGGCGCCACTTCACAGAGCAGTGGTACCCCGTGACCCTGCCAACAGGAAGTGGGGGCT
  CTGGGGGTATGGGCTCGGGGGGAGGAGGGGGGTCAGGGGGCGGCTCAGGGGGCAAAGGGAAAGGAGGCTG
  TCCTGCTGTGCGGCTGAAGGCCCGTTACCAGACAATGAGTATCCTGCCCATGGAGCTATATAAGGAGTTT
  GCAGAATATGTGACCAACCACTACCGCATGCTGTGTGCCGTGCTGGAGCCCGCCCTCAATGTCAAGGGCA
  AGGAGGAGGTCGCTAGTGCACTGGTTCACATCCTGCAAAGCACAGGCAAGGCCAAGGACTTCCTTTCAGA
  CATGGCCATGTCAGAGGTAGACCGGTTCATGGAGCGGGAACACCTCATATTCCGCGAGAACACGCTCGCC
  ACTAAAGCCATAGAAGAGTATATGAGACTGATTGGCCAGAAATACCTCAAGGATGCCATTGGGGAGTTCA
  TCCGGGCTCTGTATGAATCTGAGGAGAACTGTGAAGTAGACCCCATCAAGTGCACAGCGTCCAGTCTGGC
  AGAGCACCAGGCCAACCTGCGGATGTGCTGTGAGTTGGCCCTGTGCAAGGTGGTCAACTCCCATTGCGTG
  TTCCCGGGGGAGCTGAAGGAGGTGTTTGCATCATGGCGGCTGCGCTGTGCAGAGCGGGGCCGGGAGGACA
  TTGCTGACAGGCTGATCAGCGCCTCGCTCTTCCTGCGCTTCCTCTGCCCGGCCATCATGTCGCCCAGTCT
  GTTTGGACTGATGCAGGAGTACCCAGATGAGCAGACCTCACGAACCCTCACCCTCATCGCCAAGGTTATC
  CAGAACCTGGCCAACTTTTCCAAGTTTACCTCAAAGGAGGACTTCCTGGGCTTCATGAACGAGTTTCTGG
  AGCTGGAGTGGGGTTCTATGCAGCAATTCTTGTATGAGATATCCAACCTGGACACACTGACCAACAGCAG
  CAGTTTTGAGGGCTACATAGACTTGGGCCGCGAGCTCTCCACACTTCACGCCCTGCTCTGGGAGGTGCTG
  CCCCAGCTCAGCAAGGAAGCCCTCCTGAAGCTGGGCCCGCTGCCCCGGCTCCTCAGCGACATCAGCACAG
  CCCTGAGGAACCCTAACATCCAAAGGCAGCCGAGCCGCCAGAGCGAGCGCGCTCGGTCTCAGCCCATGGT
  GCTGCGCGGGCCGTCAGCCGAGATGCAGGGCTACATGATGCGGGACCTCAACAGCTCCATCGACCTTCAG
  TCCTTCATGGCTCGAGGCCTCAACAGCTCTATGGACATGGCTCGCCTCCCCTCCCCAACCAAGGAGAAAC
  CCCCGCCGCCCCCTCCCGGTGGGGGTAAAGACCTGTTCTATGTGAGCCGGCCACCACTGGCCCGGTCCTC
  CCCAGCATACTGCACGAGCAGCTCGGACATCACAGAGCCGGAGCAGAAGATGCTGAGTGTCAACAAGAGT
  GTGTCCATGCTGGACCTGCAGGGCGACGGGCCTGGGGGCCGCCTTAACAGCAGTAGTGTTTCCAACCTGG
  CAGCTGTTGGGGACCTGTTGCACTCAAGCCAGGCTTCACTGACAGCAGCCTTGGGGTTGCGGCCTGCACC
  TGCCGGGCGCCTCTCCCAAGGGAGTGGCTCTTCCATCACAGCAGCCGGCATGCGCCTCAGCCAGATGGGT
  GTCACTACGGATGGTGTCCCCGCCCAGCAACTGCGCATCCCTCTTTCCTTCCAGAACCCTCTCTTCCATA
  TGGCTGCCGATGGACCAGGGCCCCCAGCAGGCCATGGAGGGAGCAGTGGCCATGGTCCACCTTCCTCCCA
  TCACCACCACCACCACCATCACCATCACCGAGGGGGAGAACCCCCAGGGGACACTTTTGCCCCGTTCCAT
  GGCTATAGCAAGAGCGAGGACCTCTCTACAGGGGTCCCTAAGCCCCCTGCGGCCTCCATCCTTCACAGCC
  ACAGCTACAGTGATGAGTTTGGACCCTCTGGTACTGATTTTACCCGTCGGCAGCTCTCACTTCAGGACAA
  CCTACAGCACATGCTCTCCCCGCCCCAGATCACCATCGGTCCCCAGAGGCCAGCTCCCTCAGGGCCAGGA
  GGGGGCAGTGGTGGGGGCAGTGGTGGGGGCGGTGGGGGCCAGCCACCTCCCTTGCAGAGGGGCAAATCTC
  AGCAGTTGACAGTGAGTGCTGCCCAGAAACCCCGGCCGTCCAGCGGGAACCTATTGCAGTCCCCGGAACC
  AAGTTATGGTCCTGCCCGTCCACGGCAACAGAGCCTCAGCAAAGAGGGCAGCATTGGGGGCAGCGGGGGC
  AGCGGTGGCGGAGGGGGTGGGGGGCTCAAGCCCTCCATCACCAAGCAGCATTCCCAGACTCCATCCACGC
  TGAACCCCACGATGCCGGCCTCGGAGCGGACTGTAGCCTGGGTGTCCAATATGCCTCACCTGTCCGCTGA
  CATCGAGAGTGCACACATTGAGCGGGAAGAGTACAAGCTGAAGGAGTACTCGAAGTCCATGGACGAGAGC
  CGACTGGACAGGGTGAAGGAGTACGAGGAGGAGATCCACTCACTGAAGGAAAGGCTACACATGTCCAACC
  GGAAGCTGGAAGAGTACGAGCGGAGGCTGCTGTCCCAGGAAGAGCAGACCAGCAAGATCCTGATGCAGTA
  CCAAGCCCGCCTGGAGCAGAGCGAGAAGCGCTTGAGGCAGCAGCAGGTGGAGAAGGACTCCCAGATCAAG
  AGCATCATTGGCAGGCTGATGCTGGTGGAGGAGGAGCTGCGCCGGGACCACCCCGCCATGGCTGAGCCGC
  TGCCTGAACCCAAGAAGAGGCTGCTCGACGCTCAGAGAGGCAGCTTCCCCCCTTGGGTCCAACAAACCCG
  CGTGTGA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_181092
• ORF Size: 3927 bp
• Insert Size: 3927
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_181092.4, NP_851606.3
• RefSeq Size: 4792
• RefSeq ORF: 3927
• Locus ID: 192117
• Gene Summary: This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Homozygous null mutations in mice result in early post-embryonic lethality, while heterozygous mutant mice display a variety of phenotypes that include learning and memory defects, hyperactivity, and audiogenic seizures. [provided by RefSeq, Nov 2016]
  Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.