Syngap1 (NM_001113409) Rat Untagged Clone

CAT#: RN200180

Syngap1 (untagged ORF) - Rat synaptic Ras GTPase activating protein 1 homolog (rat) (Syngap1), transcript variant 2, (10 ug)

Specifications

Product Data

• Type: Rat Untagged Clone
• Tag: Tag Free
• Symbol: Syngap1
• Synonyms: Syngap
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >RN200180 representing NM_001113409
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGGCTTAAGGCCCCCCACCCCGACCCCGTCAGGGGGCTCCGGTTCAGGTTCCTTGCCCCCTCCTTCCC
  ACCGCCAGCCTCTCCGCCGCCGCTGCTCTTCCTGCTGCTTTCCGGGGGAATACCACTTGGGTCGCTCGAG
  GAGGAAGAGTGTCCCCGGGGGGAAACAGTACAGCATGGAAGCCGCCCCCGCTGCGCCCTTCCGGCCCTCG
  CAAGGCTTCCTGAGCCGGAGGCTAAAAAGCTCCATCAAACGTACAAAGTCACAACCCAAACTTGACCGGA
  CCAGCAGCTTTCGACAGATCCTGCCTCGCTTCCGAAGTGCTGACCATGACCGGGCCCGGCTGATGCAGAG
  CTTCAAGGAGTCTCACTCCCATGAGTCCCTGCTGAGTCCCAGCAGTGCTGCTGAGGCCCTGGAGCTCAAC
  CTGGATGAAGACTCCATTATCAAGCCAGTACACAGCTCCATCCTGGGCCAGGAGTTCTGCTTTGAGGTAA
  CAACATCGTCTGGGACAAAATGTTTTGCCTGTCGGTCTGCAGCCGAAAGGGACAAATGGATTGAGAATCT
  ACAGAGGGCTGTGAAACCCAACAAGGACAACAGCCGCCGGGTAGATAACGTGCTGAAACTATGGATCATA
  GAAGCTCGAGAGCTGCCCCCCAAGAAGCGATATTACTGCGAGTTATGCCTGGACGACATGCTCTATGCAC
  GGACCACTTCCAAGCCCCGCTCAGCCTCAGGAGACACTGTCTTTTGGGGCGAGCACTTCGAGTTTAACAA
  CCTGCCTGCTGTCCGGGCGCTGCGGCTGCATCTGTACCGTGACTCGGACAAAAAGCGGAAGAAGGACAAG
  GCAGGCTACGTTGGCCTGGTGACTGTTCCAGTGGCCACCCTGGCTGGGCGCCACTTCACAGAGCAGTGGT
  ACCCCGTGACCCTGCCAACAGGAAGTGGGGGCTCTGGGGGTATGGGCTCGGGGGGAGGAGGGGGGTCAGG
  GGGCGGCTCAGGGGGCAAAGGGAAAGGAGGCTGTCCTGCTGTGCGGCTGAAGGCCCGTTACCAGACAATG
  AGTATCCTGCCCATGGAGCTATATAAGGAGTTTGCAGAATATGTGACCAACCACTACCGCATGCTGTGTG
  CCGTGCTGGAGCCCGCCCTCAATGTCAAGGGCAAGGAGGAGGTCGCTAGTGCACTGGTTCACATCCTGCA
  AAGCACAGGCAAGGCCAAGGACTTCCTTTCAGACATGGCCATGTCAGAGGTAGACCGGTTCATGGAGCGG
  GAACACCTCATATTCCGCGAGAACACGCTCGCCACTAAAGCCATAGAAGAGTATATGAGACTGATTGGCC
  AGAAATACCTCAAGGATGCCATTGGGGAGTTCATCCGGGCTCTGTATGAATCTGAGGAGAACTGTGAAGT
  AGACCCCATCAAGTGCACAGCGTCCAGTCTGGCAGAGCACCAGGCCAACCTGCGGATGTGCTGTGAGTTG
  GCCCTGTGCAAGGTGGTCAACTCCCATTGCGTGTTCCCGGGGGAGCTGAAGGAGGTGTTTGCATCATGGC
  GGCTGCGCTGTGCAGAGCGGGGCCGGGAGGACATTGCTGACAGGCTGATCAGCGCCTCGCTCTTCCTGCG
  CTTCCTCTGCCCGGCCATCATGTCGCCCAGTCTGTTTGGACTGATGCAGGAGTACCCAGATGAGCAGACC
  TCACGAACCCTCACCCTCATCGCCAAGGTTATCCAGAACCTGGCCAACTTTTCCAAGTTTACCTCAAAGG
  AGGACTTCCTGGGCTTCATGAACGAGTTTCTGGAGCTGGAGTGGGGTTCTATGCAGCAATTCTTGTATGA
  GATATCCAACCTGGACACACTGACCAACAGCAGCAGTTTTGAGGGCTACATAGACTTGGGCCGCGAGCTC
  TCCACACTTCACGCCCTGCTCTGGGAGGTGCTGCCCCAGCTCAGCAAGGAAGCCCTCCTGAAGCTGGGCC
  CGCTGCCCCGGCTCCTCAGCGACATCAGCACAGCCCTGAGGAACCCTAACATCCAAAGGCAGCCGAGCCG
  CCAGAGCGAGCGCGCTCGGTCTCAGCCCATGGTGCTGCGCGGGCCGTCAGCCGAGATGCAGGGCTACATG
  ATGCGGGACCTCAACAGCTCCATCGACCTTCAGTCCTTCATGGCTCGAGGCCTCAACAGCTCTATGGACA
  TGGCTCGCCTCCCCTCCCCAACCAAGGAGAAACCCCCGCCGCCCCCTCCCGGTGGGGGTAAAGACCTGTT
  CTATGTGAGCCGGCCACCACTGGCCCGGTCCTCCCCAGCATACTGCACGAGCAGCTCGGACATCACAGAG
  CCGGAGCAGAAGATGCTGAGTGTCAACAAGAGTGTGTCCATGCTGGACCTGCAGGGCGACGGGCCTGGGG
  GCCGCCTTAACAGCAGTAGTGTTTCCAACCTGGCAGCTGTTGGGGACCTGTTGCACTCAAGCCAGGCTTC
  ACTGACAGCAGCCTTGGGGTTGCGGCCTGCACCTGCCGGGCGCCTCTCCCAAGGGAGTGGCTCTTCCATC
  ACAGCAGCCGGCATGCGCCTCAGCCAGATGGGTGTCACTACGGATGGTGTCCCCGCCCAGCAACTGCGCA
  TCCCTCTTTCCTTCCAGAACCCTCTCTTCCATATGGCTGCCGATGGACCAGGGCCCCCAGCAGGCCATGG
  AGGGAGCAGTGGCCATGGTCCACCTTCCTCCCATCACCACCACCACCACCATCACCATCACCGAGGGGGA
  GAACCCCCAGGGGACACTTTTGCCCCGTTCCATGGCTATAGCAAGAGCGAGGACCTCTCTACAGGGGTCC
  CTAAGCCCCCTGCGGCCTCCATCCTTCACAGCCACAGCTACAGTGATGAGTTTGGACCCTCTGGTACTGA
  TTTTACCCGTCGGCAGCTCTCACTTCAGGACAACCTACAGCACATGCTCTCCCCGCCCCAGATCACCATC
  GGTCCCCAGAGGCCAGCTCCCTCAGGGCCAGGAGGGGGCAGTGGTGGGGGCAGTGGTGGGGGCGGTGGGG
  GCCAGCCACCTCCCTTGCAGAGGGGCAAATCTCAGCAGTTGACAGTGAGTGCTGCCCAGAAACCCCGGCC
  GTCCAGCGGGAACCTATTGCAGTCCCCGGAACCAAGTTATGGTCCTGCCCGTCCACGGCAACAGAGCCTC
  AGCAAAGAGGGCAGCATTGGGGGCAGCGGGGGCAGCGGTGGCGGAGGGGGTGGGGGGCTCAAGCCCTCCA
  TCACCAAGCAGCATTCCCAGACTCCATCCACGCTGAACCCCACGATGCCGGCCTCGGAGCGGACTGTAGC
  CTGGGTGTCCAATATGCCTCACCTGTCCGCTGACATCGAGAGTGCACACATTGAGCGGGAAGAGTACAAG
  CTGAAGGAGTACTCGAAGTCCATGGACGAGAGCCGACTGGACAGGGTGAAGGAGTACGAGGAGGAGATCC
  ACTCACTGAAGGAAAGGCTACACATGTCCAACCGGAAGCTGGAAGAGTACGAGCGGAGGCTGCTGTCCCA
  GGAAGAGCAGACCAGCAAGATCCTGATGCAGTACCAAGCCCGCCTGGAGCAGAGCGAGAAGCGCTTGAGG
  CAGCAGCAGGTGGAGAAGGACTCCCAGATCAAGAGCATCATTGGCAGGCTGATGCTGGTGGAGGAGGAGC
  TGCGCCGGGACCACCCCGCCATGGCTGAGCCGCTGCCTGAACCCAAGAAGAGGCTGCTCGACGCTCAGAG
  AGGCAGCTTCCCCCCTTGGGTCCAACAAACCCGCGTGTGA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_001113409
• ORF Size: 3750 bp
• Insert Size: 3750
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_001113409.2, NP_001106880.2
• RefSeq Size: 4729
• RefSeq ORF: 3750
• Locus ID: 192117
• Gene Summary: This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Homozygous null mutations in mice result in early post-embryonic lethality, while heterozygous mutant mice display a variety of phenotypes that include learning and memory defects, hyperactivity, and audiogenic seizures. [provided by RefSeq, Nov 2016]
  Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.