Mpz (NM_017027) Rat Untagged Clone

CAT#: RN204943

Mpz (untagged ORF) - Rat myelin protein zero (Mpz), (10 ug)

Specifications

Product Data

• Type: Rat Untagged Clone
• Tag: Tag Free
• Symbol: Mpz
• Synonyms: MPP; P0
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >RN204943 representing NM_017027
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGCTCCTGGGGCTCCCTCATCCAGCCCCAGCCCTATCCTGGCTGCCCTGCTCTTCTCTTCTTTGGTGC
  TGTCCCCAACCCTGGCCATTGTGGTTTACACGGACAGGGAAGTCTATGGTGCTGTGGGCTCCCAGGTGAC
  CCTGCACTGCTCCTTCTGGTCCAGTGAATGGGTCTCAGATGACATCTCTTTTACCTGGCGCTACCAGCCT
  GAAGGAGGCCGAGATGCCATTTCAATCTTCCACTATGCCAAGGGTCAACCTTACATCGATGAGGTGGGGA
  CCTTCAAGGAGCGCATCCAGTGGGTAGGGGACCCTAGCTGGAAGGATGGCTCCATTGTCATACACAACCT
  AGACTACAGTGACAACGGCACTTTCACATGTGATGTCAAAAACCCACCGGACATAGTGGGCAAGACGTCT
  CAGGTCACGCTCTATGTCTTTGAAAAAGTGCCCACTAGGTATGGGGTGGTGTTGGGAGCCGTGATCGGTG
  GCATCCTCGGGGTGGTGCTGTTGCTGCTGTTGCTCTTCTACCTGATCCGGTACTGCTGGCTGCGCAGGCA
  GGCTGCCCTGCAGAGGAGGCTCAGTGCCATGGAGAAGGGGAAATTTCACAAGTCTTCTAAGGACTCCTCG
  AAGCGCGGGCGGCAGACGCCAGTGCTGTATGCCATGCTGGACCACAGCCGAAGCACCAAAGCTGCCAGTG
  AGAAGAAATCTAAAGGGCTGGGGGAGTCTCGCAAGGATAAGAAATAG
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_017027
• ORF Size: 747 bp
• Insert Size: 747
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_017027.2, NP_058723.2
• RefSeq Size: 2018
• RefSeq ORF: 747
• Locus ID: 24564
• Gene Summary: This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in the orthologous gene in human are associated with myelinating neuropathies. A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2015]
  Transcript Variant: This transcript (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (MPZ, also known as P0) results from translation termination at the upstream UAG stop codon, while the longer isoform (L-MPZ) results from UAG stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (MPZ).