Hrh3 (NM_001270564) Rat Untagged Clone

CAT#: RN216602

Hrh3 (untagged) - Rat histamine receptor H3 (Hrh3), transcript variant 2

Specifications

Product Data

• Type: Rat Untagged Clone
• Tag: Tag Free
• Symbol: Hrh3
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >RN216602 representing NM_001270564
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGAGCGCGCGCCGCCCGACGGGCTGATGAACGCGTCGGGCACTCTGGCCGGAGAGGCGGCGGCTGCAG
  GCGGGGCGCGCGGCTTCTCGGCTGCCTGGACCGCTGTCCTGGCTGCGCTCATGGCGCTGCTCATCGTGGC
  CACAGTACTGGGCAACGCGCTGGTCATGCTCGCCTTCGTGGCGGATTCGAGCCTCCGCACCCAGAACAAC
  TTCTTTCTGCTCAACCTCGCCATCTCCGACTTCCTCGTGGGTGCCTTCTGCATCCCATTGTACGTACCCT
  ATGTGCTGACCGGCCGTTGGACCTTCGGCCGGGGCCTCTGCAAGCTGTGGCTGGTGGTAGACTACCTACT
  GTGTGCCTCCTCGGTCTTCAACATCGTACTCATCAGCTATGACCGATTCCTGTCAGTCACTCGAGCTGTC
  TCCTACAGGGCCCAGCAGGGGGACACGAGACGGGCCGTTCGGAAGATGGCACTGGTGTGGGTGCTGGCCT
  TCCTGCTGTATGGGCCTGCCATCCTGAGTTGGGAGTACCTGTCTGGTGGCAGTTCCATCCCCGAGGGCCA
  CTGCTATGCTGAGTTCTTCTACAACTGGTACTTTCTCATCACGGCCTCCACCCTCGAGTTCTTCACGCCC
  TTCCTCAGCGTTACCTTCTTCAACCTCAGCATCTACCTGAACATCCAGAGGCGCACCCGCCTTCGGCTTG
  ATGGGGGCCGTGAGGCTGGCCCAGAACCCCCACCAGATGCCCAGCCCTCGCCACCTCCAGCTCCCCCCAG
  CTGCTGGGGCTGCTGGCCAAAAGGGCATGGCGAGGCCATGCCGTTGCACAGCTCTGGCAGCTCCTCAAGG
  GGCACTGAGAGGCCACGCTCACTCAAAAGGGGCTCCAAGCCATCAGCATCTTCAGCATCCCTGGAGAAGC
  GCATGAAGATGGTGTCCCAGAGCATCACCCAGCGCTTCCGGCTGTCGCGGGACAAGAAGGTGGCCAAGTC
  GCTGGCCATCATCGTGAGCATCTTTGGGCTCTGCTGGGCGCCGTACACGCTCCTAATGATCATCCGAGCT
  GCTTGCCATGGCCGCTGCATCCCCGATTACTGGTACGAGACGTCCTTCTGGCTTCTGTGGGCCAACTCGG
  CCGTCAACCCCGTCCTCTACCCACTGTGCCACTACAGCTTCCGCAGAGCCTTCACCAAGCTCCTCTGCCC
  CCAGAAGCTCAAGGTCCAGCCCCACGGCTCCCTGGAGCAGTGCTGGAAGTGA
  
  AGCGGACCGACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCC
  TGGATTACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-RsrII
• ACCN: NM_001270564
• ORF Size: 1242 bp
• Insert Size: 1242
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This clone expresses the complete ORF with c-terminal tags of Myc-DDK.

Reference Data

• RefSeq: NM_001270564.1, NP_001257493.1
• RefSeq Size: 2696
• RefSeq ORF: 1242
• Locus ID: 85268
• Gene Summary: This gene encodes a histamine H3 receptor that belongs to the superfamily of G-protein coupled receptors. This protein functions as a presynaptic autoreceptor on histamine neurons in the brain, and a presynaptic heteroreceptor in nonhistamine-containing neurons in both the central and peripheral nervous systems. It is deemed a great target for the development of therapeutics for numerous disorders, including obesity, epilepsy, and such cognitive diseases as attention deficit hyperactivity disorder and Alzheimer's disease. Several alternatively spliced transcript variants encoding different isoforms, with different brain expression patterns and signaling properties, have been described for this gene. [provided by RefSeq, Jul 2012]
  Transcript Variant: This variant (2) is alternatively spliced at the 3' end compared to variant 1, and encodes a shorter isoform (H3B, also known as H3S or H3(413)) containing 7 transmembrane domains, but missing part of the third intracellular loop compared to isoform H3A. This isoform is thought to function as the histamine autoreceptor (PMID:22356432).