Hrh3 (NM_001270564) Rat Untagged Clone

CAT#: RN216602

Hrh3 (untagged) - Rat histamine receptor H3 (Hrh3), transcript variant 2


  "NM_001270564" in other vectors (1)

Reconstitution Protocol

USD 410.00

3 Weeks*

Size
    • 10 ug

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Specifications

Product Data
Type Rat Untagged Clone
Tag Tag Free
Symbol Hrh3
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>RN216602 representing NM_001270564
Red=Cloning site Blue=ORF Orange=Stop codon

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGGAGCGCGCGCCGCCCGACGGGCTGATGAACGCGTCGGGCACTCTGGCCGGAGAGGCGGCGGCTGCAG
GCGGGGCGCGCGGCTTCTCGGCTGCCTGGACCGCTGTCCTGGCTGCGCTCATGGCGCTGCTCATCGTGGC
CACAGTACTGGGCAACGCGCTGGTCATGCTCGCCTTCGTGGCGGATTCGAGCCTCCGCACCCAGAACAAC
TTCTTTCTGCTCAACCTCGCCATCTCCGACTTCCTCGTGGGTGCCTTCTGCATCCCATTGTACGTACCCT
ATGTGCTGACCGGCCGTTGGACCTTCGGCCGGGGCCTCTGCAAGCTGTGGCTGGTGGTAGACTACCTACT
GTGTGCCTCCTCGGTCTTCAACATCGTACTCATCAGCTATGACCGATTCCTGTCAGTCACTCGAGCTGTC
TCCTACAGGGCCCAGCAGGGGGACACGAGACGGGCCGTTCGGAAGATGGCACTGGTGTGGGTGCTGGCCT
TCCTGCTGTATGGGCCTGCCATCCTGAGTTGGGAGTACCTGTCTGGTGGCAGTTCCATCCCCGAGGGCCA
CTGCTATGCTGAGTTCTTCTACAACTGGTACTTTCTCATCACGGCCTCCACCCTCGAGTTCTTCACGCCC
TTCCTCAGCGTTACCTTCTTCAACCTCAGCATCTACCTGAACATCCAGAGGCGCACCCGCCTTCGGCTTG
ATGGGGGCCGTGAGGCTGGCCCAGAACCCCCACCAGATGCCCAGCCCTCGCCACCTCCAGCTCCCCCCAG
CTGCTGGGGCTGCTGGCCAAAAGGGCATGGCGAGGCCATGCCGTTGCACAGCTCTGGCAGCTCCTCAAGG
GGCACTGAGAGGCCACGCTCACTCAAAAGGGGCTCCAAGCCATCAGCATCTTCAGCATCCCTGGAGAAGC
GCATGAAGATGGTGTCCCAGAGCATCACCCAGCGCTTCCGGCTGTCGCGGGACAAGAAGGTGGCCAAGTC
GCTGGCCATCATCGTGAGCATCTTTGGGCTCTGCTGGGCGCCGTACACGCTCCTAATGATCATCCGAGCT
GCTTGCCATGGCCGCTGCATCCCCGATTACTGGTACGAGACGTCCTTCTGGCTTCTGTGGGCCAACTCGG
CCGTCAACCCCGTCCTCTACCCACTGTGCCACTACAGCTTCCGCAGAGCCTTCACCAAGCTCCTCTGCCC
CCAGAAGCTCAAGGTCCAGCCCCACGGCTCCCTGGAGCAGTGCTGGAAGTGA


AGCGGACCGACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCC
TGGATTACAAGGATGACGACGATAAGGTTTAA
Restriction Sites SgfI-RsrII     
ACCN NM_001270564
ORF Size 1242 bp
Insert Size 1242
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation This clone expresses the complete ORF with c-terminal tags of Myc-DDK.
Reference Data
RefSeq NM_001270564.1, NP_001257493.1
RefSeq Size 2696
RefSeq ORF 1242
Locus ID 85268
Gene Summary This gene encodes a histamine H3 receptor that belongs to the superfamily of G-protein coupled receptors. This protein functions as a presynaptic autoreceptor on histamine neurons in the brain, and a presynaptic heteroreceptor in nonhistamine-containing neurons in both the central and peripheral nervous systems. It is deemed a great target for the development of therapeutics for numerous disorders, including obesity, epilepsy, and such cognitive diseases as attention deficit hyperactivity disorder and Alzheimer's disease. Several alternatively spliced transcript variants encoding different isoforms, with different brain expression patterns and signaling properties, have been described for this gene. [provided by RefSeq, Jul 2012]
Transcript Variant: This variant (2) is alternatively spliced at the 3' end compared to variant 1, and encodes a shorter isoform (H3B, also known as H3S or H3(413)) containing 7 transmembrane domains, but missing part of the third intracellular loop compared to isoform H3A. This isoform is thought to function as the histamine autoreceptor (PMID:22356432).

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