Acmsd (NM_134372) Rat Tagged ORF Clone

CAT#: RR212337

Acmsd (Myc-DDK-tagged ORF) - Rat aminocarboxymuconate semialdehyde decarboxylase (Acmsd), (10 ug)

Specifications

Product Data

• Type: Rat Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: Acmsd
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RR212337 representing NM_134372
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGAAAATTGACATCCACACTCACATTCTACCAAAGGAATGGCCTGATCTAGAAAAGAGGTTTGGCTATG
  GAGGCTGGGTGCAGCTCCAACAGCAAGGCAAGGGAGAAGCAAAGATGATGAAAGACGGGAAGGTCTTCAG
  AGTGATCCAACAGAACTGCTGGGACCCAGAAGTCCGCATCAGAGAAATGAACCAGAAAGGAGTGACAGTG
  CAAGCTCTTTCCACAGTTCCCGTCATGTTTAGTTACTGGGCCAAACCTAAGGACACTTTGGAACTGTGCC
  AGTTTTTAAACAATGACCTCGCTGCCACGGTGGCCAGATACCCTCGAAGGTTTGTGGGTTTGGGGACATT
  GCCTATGCAAGCCCCGGGGCTGGCTGTCGAGGAGATGGAGCGTTGTGTAAAGGAGCTAGGATTTCCAGGA
  ATCCAGATTGGATCCCACATCAACATGTGGGACCTGAATGACCCGGAACTCTTCCCCATCTACACGGCGG
  CTGAGAGGCTGAATTGTTCTCTGTTCGTGCATCCCTGGGATATGCAGATGGATGGACGGATGGCCAAATA
  CTGGCTGCCTTGGCTCGTAGGAATGCCATCGGAGACCACCACGGCCATTTGCTCCATGATCATGGGTGGG
  GTGTTCGAGAAGTTTCCCAAACTCAAAGTGTGTTTTGCACATGGAGGTGGTGCTTTCCCCTTCACCATAG
  GAAGAATTGCTCATGGATTTAACATGCGCCCAGATCTCTGTGCCCGGGACAATTCATCTGACCCCAGAAA
  ATACCTTGGCTCCTTCTACACGGACTCCCTGGTTCATGATCCTCTGTCTCTCAAGCTATTGACAGATGTT
  ATAGGGAAGGATAGAGTTATTCTGGGAACTGATTACCCCTTTCCACTAGGTGAGCAGGAGCCTGGGAAGT
  TGATAGAGTCTATGGCAGACTTTGATGAAGAAACAAAGGATAAACTTACAGCTGGCAATGCCTTGACTTT
  TTTGGGTCTTGAGAGAAAACTATTTGAA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
  Protein Sequence

  >RR212337 representing NM_134372
  Red=Cloning site Green=Tags(s)
  
  MKIDIHTHILPKEWPDLEKRFGYGGWVQLQQQGKGEAKMMKDGKVFRVIQQNCWDPEVRIREMNQKGVTV
  QALSTVPVMFSYWAKPKDTLELCQFLNNDLAATVARYPRRFVGLGTLPMQAPGLAVEEMERCVKELGFPG
  IQIGSHINMWDLNDPELFPIYTAAERLNCSLFVHPWDMQMDGRMAKYWLPWLVGMPSETTTAICSMIMGG
  VFEKFPKLKVCFAHGGGAFPFTIGRIAHGFNMRPDLCARDNSSDPRKYLGSFYTDSLVHDPLSLKLLTDV
  IGKDRVILGTDYPFPLGEQEPGKLIESMADFDEETKDKLTAGNALTFLGLERKLFE
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_134372
• ORF Size: 1008 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_134372.1, NP_599199.1
• RefSeq Size: 1011
• RefSeq ORF: 1011
• Locus ID: 171385
• MW: 38.1 kDa
• Gene Summary: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. [UniProtKB/Swiss-Prot Function]