ISCU (NM_014301) Human Untagged Clone
CAT#: SC100422
ISCU (untagged)-Human iron-sulfur cluster scaffold homolog (E. coli) (ISCU), nuclear gene encoding mitochondrial protein, transcript variant 1
"NM_014301" in other vectors (4)
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Specifications
Product Data | |
Type | Human Untagged Clone |
Tag | Tag Free |
Symbol | ISCU |
Synonyms | 2310020H20Rik; HML; hnifU; ISU2; NIFU; NIFUN |
Vector | pCMV6-XL4 |
E. coli Selection | Ampicillin (100 ug/mL) |
Mammalian Cell Selection | None |
Sequence Data |
>OriGene ORF within SC100422 sequence for NM_014301 edited (data generated by NextGen Sequencing)
ATGGTTCTCATTGACATGAGTGTAGACCTTTCTACTCAGGTTGTTGATCATTATGAAAAT CCTAGAAACGTGGGGTCCCTTGACAAGACATCTAAAAATGTTGGAACTGGACTGGTGGGG GCTCCAGCATGTGGTGACGTAATGAAATTACAGATTCAAGTGGATGAAAAGGGGAAGATT GTGGATNNNAGGTTTAAAACATTTGGCTGTGGTTCCGCAATTGCCTCCAGCTCATTAGCC ACTGAATGGGTGAAAGGAAAGACGGTGGAGGAAGCCTTGACTATCAAAAACACAGATATC GCCAAGGAGCTCTGCCTTCCTCCCGTGAAACTGCACTGCTCCATGCTGGCTGAAGATGCA ATCAAGGCCGCCCTGGCTGATTACAAATTGAAACAAGAACCCAAAAAAGGAGAGGCAGAG AAGAAATGA Clone variation with respect to NM_014301.3 187 g=>n;188 c=>n;189 t=>n >OriGene 5' read for NM_014301 unedited
GCGGTGCACCAATTGTAAACGACTCACTATAGGCGGCCGCGAATCGGCACGAGGGCGCGC TCCCAGCTCGGAGCCGACTCGCAGACGCGCCCCGCCCCTCGGCGTCGCTCTGGACTGGCG CAGGCGCAAGCCGGCAAGATGGCGGCGGCTGGGGCTGGCCGTCTGAGGCGGGTGGCATCG GCTCTGCTGCTGCGGAGCCCCCGCCTGCCCGCCCGGGAGCTGTCGGCCCCGGCCCGACTC TATCACAAGAAGGTAGGGACAAAAGAGGGGACGCGCGGAATGCCGACTCAGCGGAGGCCT GGGCTGGAGGGGCGGCCGCGGGGTTCTGCGCAGCTAGGACTGGGAGCTGTGCCCTCCCAC GTCTTTGCCCTGACTCGCTTTCCCTTGCTGCGCAGTGAGGCTCACTGCAACTGATAAACA ACAGTTACCGCTCATCGGGCGGCGACTTCCAGGGGGCCCCGCCGCTGGCCGCGACTTCGT GCGTCCCAATTTTAAATTCGCCAACAGCCCAGGAGGCAGGGTCCTGTTGGGACTTGTCTT TCTGAGTCCAGGGACAGACACACCCCCGGAGCGGGCTCCGGCTTCAGCCACTCCGCTGCC CTGGCCAGATGACCTTGGGCTAGTCACTGCGCCTCTCTGAACCTGTTTCCCCAGGTGTAA ATGGGGGGCTCTCAGCTGTCCCTTCCAAGGATACTGTGCGTGGAGTCCTGGCATGGTTCC TGGCACATANGCCCCAGCACGAGGAGACCGTTTCTGTTACTGCNTTANGAGTGCATAAGG GAGTCAGGGCTGTTACCAACATGCGTANATGTTTTTGTTTGTTTGGGGGGGTTTTTTGGC GGGGAAAGAGGGATAGATTCATAGTCTGCAGCCCCTTGCTGTCTGGTGGCCCAAAGTCCC CCANACGTGAAACTC |
Restriction Sites | NotI-NotI |
ACCN | NM_014301 |
ORF Size | 429 bp |
Insert Size | 4300 |
OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
Reference Data | |
RefSeq | NM_014301.2, NP_055116.1 |
RefSeq Size | 1086 |
RefSeq ORF | 429 |
Locus ID | 23479 |
Domains | NifU_N |
Gene Summary | This gene encodes a component of the iron-sulfur (Fe-S) cluster scaffold. Fe-S clusters are cofactors that play a role in the function of a diverse set of enzymes, including those that regulate metabolism, iron homeostasis, and oxidative stress response. Alternative splicing results in transcript variants encoding different protein isoforms that localize either to the cytosol or to the mitochondrion. Mutations in this gene have been found in patients with hereditary myopathy with lactic acidosis. A disease-associated mutation in an intron may activate a cryptic splice site, resulting in the production of a splice variant encoding a putatively non-functional protein. A pseudogene of this gene is present on chromosome 1. [provided by RefSeq, Feb 2016] Transcript Variant: This variant (1) contains an alternate exon in the 5' region and initiates translation at an alternate start codon compared to variant 2. The encoded isoform (1) has a distinct, shorter N-terminus, compared to isoform 2. Isoform 1 is localized to the cytosol. |
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Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
RC212031 | ISCU (Myc-DDK-tagged)-Human iron-sulfur cluster scaffold homolog (E. coli) (ISCU), nuclear gene encoding mitochondrial protein, transcript variant 1 |
USD 98.00 |
|
RG212031 | ISCU (GFP-tagged) - Human iron-sulfur cluster scaffold homolog (E. coli) (ISCU), nuclear gene encoding mitochondrial protein, transcript variant 1 |
USD 460.00 |
|
RC212031L3 | Lenti ORF clone of Human iron-sulfur cluster scaffold homolog (E. coli) (ISCU), nuclear gene encoding mitochondrial protein, transcript variant 1, Myc-DDK-tagged |
USD 620.00 |
|
RC212031L4 | Lenti ORF clone of Human iron-sulfur cluster scaffold homolog (E. coli) (ISCU), nuclear gene encoding mitochondrial protein, transcript variant 1, mGFP tagged |
USD 620.00 |
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