Nicastrin (NCSTN) (NM_015331) Human Untagged Clone

CAT#: SC100655

NCSTN (untagged)-Human nicastrin (NCSTN)


  "NM_015331" in other vectors (6)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol NCSTN
Synonyms ATAG1874
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC100655 sequence for NM_015331 edited (data generated by NextGen Sequencing)
ATGGCTACGGCAGGGGGTGGCTCTGGGGCTGACCCGGGAAGTCGGGGTCTCCTTCGCCTT
CTGTCTTTCTGCGTCCTACTAGCAGGTTTGTGCAGGGGAAACTCAGTGGAGAGGAAGATA
TATATCCCCTTAAATAAAACAGCTCCCTGTGTTCGCCTGCTCAACGCCACTCATCAGATT
GGCTGCCAGTCTTCAATTAGTGGAGACACAGGGGTTATCCACGTAGTAGAGAAAGAGGAG
GACCTACAGTGGGTATTGACTGATGGCCCCAACCCCCCTTACATGGTTCTGCTGGAGAGC
AAGCATTTTACCAGGGATTTAATGGAGAAGCTGAAAGGGAGAACCAGCCGAATTGCTGGT
CTTGCAGTGTCCTTGACCAAGCCCAGTCCTGCCTCAGGCTTCTCTCCTAGTGTACAGTGC
CCAAATGATGGGTTTGGTGTTTACTCCAATTCCTATGGGCCAGAGTTTGCTCACTGCAGA
GAAATACAGTGGAATTCGCTGGGCAATGGTTTGGCTTATGAAGACTTTAGTTTCCCCATC
TTTCTTCTTGAAGATGAAAATGAAACCAAAGTCATCAAGCAGTGCTATCAAGATCACAAC
CTGAGTCAGAATGGCTCAGCACCAACCTTCCCACTATGTGCCATGCAGCTCTTTTCACAC
ATGCATGCTGTCATCAGCACTGCCACCTGCATGCGGCGCAGCTCCATCCAAAGCACCTTC
AGCATCAACCCAGAAATCGTCTGTGACCCCCTGTCTGATTACAATGTGTGGAGCATGCTA
AAGCCTATAAATACAACTGGGACATTAAAGCCTGACGACAGGGTTGTGGTTGCTGCCACC
CGGCTGGATAGTCGTTCCTTTTTCTGGAATGTGGCCCCAGGGGCTGAAAGCGCAGTGGCT
TCCTTTGTCACCCAGCTGGCTGCTGCTGAAGCTTTGCAAAAGGCACCTGATGTGACCACC
CTGCCCCGCAATGTCATGTTTGTCTTCTTTCAAGGGGAAACTTTTGACTACATTGGCAGC
TCGAGGATGGTCTACGATATGGAGAAGGGCAAGTTTCCCGTGCAGTTAGAGAATGTTGAC
TCATTTGTGGAGCTGGGACAGGTGGCCTTAAGAACTTCATTAGAGCTTTGGATGCACACA
GATCCTGTTTCTCAGAAAAATGAGTCTGTACGGAACCAGGTGGAGGATCTCCTGGCCACA
TTGGAGAAGAGTGGTGCTGGTGTCCCTGCTGTCATCCTCAGGAGGCCAAATCAGTCCCAG
CCTCTCCCACCATCTTCCCTGCAGCGATTTCTTCGAGCTCGAAACATCTCTGGCGTTGTT
CTGGCTGACCACTCTGGTGCCTTCCATAACAAATATTACCAGAGTATTTACGACACTGCT
GAGAACATTAATGTGAGCTATCCCGAATGGCTGAGCCCTGAAGAGGACCTGAACTTTGTA
ACAGACACTGCCAAGGCCCTGGCAGATGTGGCCACGGTGCTGGGACGTGCTCTGTATGAG
CTTGCAGGAGGAACCAACTTCAGCGACACAGTTCAGGCTGATCCCCAAACGGTTACCCGC
CTGCTCTATGGGTTCCTGATTAAAGCCAACAACTCATGGTTCCAGTCTATCCTCAGGCAG
GACCTAAGGTCCTACTTGGGTGACGGGCCTCTTCAACATTACATCGCTGTCTCCAGCCCC
ACCAACACCACTTATGTTGTACAGTATGCCTTGGCAAATTTGACTGGCACAGTGGTCAAC
CTCACCCGAGAGCAGTGCCAGGATCCAAGTAAAGTCCCAAGTGAAAACAAGGATCTGTAT
GAGTACTCATGGGTCCAGGGCCCTTTGCATTCTAATGAGACGGACCGACTCCCCCGGTGT
GTGCGTTCTACTGCACGATTAGCCAGGGCCTTGTCTCCTGCCTTTGAACTGAGTCAGTGG
AGCTCTACTGAATACTCTACATGGACTGAGAGCCGCTGGAAAGATATCCGTGCCCGGATA
TTTCTCATCGCCAGCAAAGAGCTTGAGTTGATCACCCTGACAGTGGGCTTCGGCATCCTC
ATCTTCTCCCTCATCGTCACCTACTGCATCAATGCCAAAGCTGATGTCCTTTTCATTGCT
CCCCGGGAGCCAGGAGCTGTGTCATACTGA

Clone variation with respect to NM_015331.2
>OriGene 5' read for NM_015331 unedited
GATTTTGTAATACGACTTACTATAGGGCGGCCGCGAATTCGGCACCGCGCTAACAGACAG
AGCCGAACGGGGGCTTCCGCTCAGCAGAGAGGCAAGATGGCTACGGCAGGGGGTGGCTCT
GGGGCTGACCCGGGAAGTCGGGGTCTCCTTCGCCTTCTGTCTTTCTGCGTCCTACTAGCA
GGTTTGTGCAGGGGAAACTCAGTGGAGAGGAAGATATATATCCCCTTAAATAAAACAGCT
CCCTGTGTTCGCCTGCTCAACGCCACTCATCAGATTGGCTGCCAGTCTTCAATTAGTGGA
GACACAGGGGTTATCCACGTAGTAGAGAAAGAGGAGGACCTACAGTGGGTATTGACTGAT
GGCCCCAACCCCCCTTACATGGTTCTGCTGGAGAGCAAGCATTTTACCAGGGATTTAATG
GAGAAGCTGAAAGGGAGAACCAGCCGAATTGCTGGTCTTGCAGTGTCCTTGACCAAGCCC
AGTCCTGCCTCAGGCTTCTCTCCTAGTGTACAGTGCCCAAATGATGGGTTTGGTGTTTAC
TCCAATTCCTATGGGCCAGAGTTTGCTCACTGCAGAGAAATACAGTGGAATTCGCTGGGC
AATGGTTTGGCTTATGAAGACTTTAGTTTCCCCATCTTTCTTCTTGAAGATGAAAATGAA
ACCAAAGTCATCAAGCAGTGCTATCAAGATCACAACCTGAGTCAGAATGGCTCAGCACCA
ACCTTCCCACTATGTGCCATGCAGCTCTTTTCACACATGCATGCTGTCATCAGCACTGCC
ACCTGCATGCNGCGCAGCTCCATCCAAAGCACCTTCAGCATCAACCCAGAAATCGTCTGT
GACCCCCTGTCTGATTACCATGTGTGGAGCATGCTAAAGCCTATNAATACCACTGGGACA
TTAAAGCCTGACGACAGGGTTGTGGNTTGCTGCACCNNGCTGATAAGTCGTCCTTTTTCT
GGATGTGGCCCCAGGGGCTGAAGCGCATGGCTTCTTTGTACCCACTGGCG
>OriGene 3' read for NM_015331 unedited
GGGGGGTGAAAGTCAATGCTTTTTGATGNCAACTCTTAGTATATATTTACAAAAGCAATA
AGGAAAAAGACAAAAACAAAAATAGATATTACAGCTTAATAAAAAGTACAACTGAGCACT
GTGGGCTGGAGGTGGGATACCCACCCGCAGCACGCCCACCCTAATGTGCCATCTGAGGGC
CTGCCACAAAGGACAGTGGGCAACGAGACAGTAGGCTCAGCCCATATATTCCTCTGTCCT
CAGGGGCTCAATGTACCTTGACCCTGACATTAAACCTTTTATGTACCTTCCCAGTCACGA
AGGTGGCTTGGGTACATTGGATGCGGGCGCGCGCGATCATTATAGAGGTACAGGGCAGGA
AGGAAAAAGTAGAAGGGTCCTGAAGGGCCAATTATGGTGGGTAACTAGGGAGTTAAACAG
GAGCAAGAAGCTTCTATTTGTAATCCCGCCCTCTGGCATGACGCCGAGAAGGAAGAGGAA
ATGGGGAAGGGGTGATGGGAAAGGGGAGCGGATTGAAGTATAATCGGTGACTTTCTCTAC
ACCGATTTTCGGAATTTGCCATATTTTTTTTCCCCCGCTATTTTTTCCGCCCCCCTCCAT
CCCCCGAAATTAATGTTATGGGTTTTCACTTTACGGCGCCCACCTCTCCATTCATCCCCC
CTGATTGTTTCTCCCCATGAGCCCCCCTTTTGTTTGGCGCCCAATTGGACCAGCGGTATT
AGTTCCCACTGATTTGTATTTGTGCATAAAACGAGAGGATTGCGCCGTTTTTATGTTGTC
CCGACTGTTGGGTCCTGCCTGACTCTAATCGGCTGTAATGGGCCGTATAGAATTACGTTT
AGGCCCGGTCGCCTGTTTTTTCTCCCGTTTGTGTCGCCCCCCCCCCCCCGTTTTTTGTTT
TATTTN
Restriction Sites Please inquire     
ACCN NM_015331
ORF Size 2130 bp
Insert Size 3000
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_015331.2, NP_056146.1
RefSeq Size 2944
RefSeq ORF 2130
Locus ID 23385
Protein Families Druggable Genome, Transmembrane
Protein Pathways Alzheimer's disease, Notch signaling pathway
Gene Summary This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]
Transcript Variant: This variant (1) encodes the longest isoform (1).

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