Bestrophin 3 (BEST3) (NM_152439) Human Untagged Clone

CAT#: SC100666

BEST3 (untagged)-Human bestrophin 3 (BEST3), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: BEST3
• Synonyms: VMD2L3
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_152439, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGACAACAGATGAAAGGAAATTATTCAACCACCTCAAGTCTCCTCATCTGAAATATTGGGTTCCATTCA
  TCTGGTTTGGAAATCTTGCAACTAAAGCCCGGAATGAAGGTAGAATCAGAGACAGTGTTGATCTGCAATC
  ATTGATGACTGAAATGAATCGATACCGCTCTTGGTGCAGCCTCTTATTCGGTTATGACTGGGTTGGGATT
  CCGCTGGTTTACACCCAGGTAGCAGAGCAGCTTATCAACCCTTTTGGAGAAGATGATGATGATTTTGAAA
  CTAACTGGTGCATTGACAGAAATTTGCAGGTCTCTCTTTTAGCTGTGGACGAAATGCACATGAGCTTACC
  CAAGATGAAGAAGGACATTTACTGGGACGATTCTGCTGCTCGCCCACCATACACATTGGCAGCTGCTGAC
  TACTGCATACCCTCATTTCTGGGGTCAACAGTCCAGATGGGGCTGTCTGGGTCCGACTTTCCTGACGAGG
  AGTGGCTGTGGGATTATGAGAAGCATGGCCATCGGCATTCCATGATAAGAAGAGTCAAGCGGTTCCTGAG
  TGCCCACGAACACCCCTCCAGCCCCAGAAGAAGAAGCTACAGGAGGCAGACAAGTGACAGCTCCATGTTC
  TTACCCCGAGATGACCTCAGCCCAGCCAGGGACCTACTGGATGTGCCCTCAAGAAACCCCCCCAGGGCCT
  CACCCACCTGGAAGAAATCCTGCTTCCCAGAAGGAAGCCCCACGCTGCACTTCAGCATGGGAGAGCTGTC
  CACCATCAGGGAGACCAGCCAGACAAGCACTTTACAGAGCCTGACCCCACAGTCCAGTGTGAGAACTTCC
  CCCATCAAAATGCCACTGGTACCTGAGGTATTGATCACAGCAGCCGAAGCACCAGTGCCCACATCAGGGG
  GCTACCACCATGATTCCGCTACCTCCATCTTGAGCTCTGAGTTTACAGGGGTTCAGCCAAGCAAGACTGA
  GCAGCAGCAGGGCCCCATGGGATCCATCCTGTCTCCCTCAGAGAAGGAGACACCTCCTGGAGGCCCCAGT
  CCCCAGACAGTTTCAGCCAGCGCTGAGGAAAATATATTCAACTGTGAAGAAGACCCTGGTGATACCTTTC
  TAAAAAGGTGGAGTCTTCCGGGATTCCTGGGGTCCAGCCACACTTCCCTGGGAAACCTAAGTCCAGACCC
  CATGAGCTCTCAGCCAGCTCTTTTAATTGACACAGAAACATCCTCAGAGATCAGTGGGATCAACATTGTG
  GCTGGCTCTCGAGTCTCTTCTGATATGCTGTATTTAATGGAAAACCTGGACACCAAGGAAACAGATATCA
  TAGAGCTGAACAAGGAAACTGAGGAATCACCCAAATGA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_152439 unedited
  NATTTTGTAATACGACTCACTATAGGGCGGCCCGCGAATTCGCACGAGGACAAATGACAT
  TTTTTTTCTGGAAGGCAAAATCAGAAGATATGGATAATAATATATTTTTGTCCTCCAACC
  TCTAAAAAGGCTAAAATTCAGCTAAAAGCATCAGTGTCACCAACGTGTCTGCTGTAAGAA
  ACTGCTTTATAATTTCCTGTTATTCTACAGGGTTTTATGTTACTCTGGTAGTGAACCGAT
  GGTGGAACCAGTTTGTGAATTTGCCCTGGCCAGACAGGCTAATGTTCCTCATCTCTAGCA
  GTGTTCACGGAAGCGACGAGCACGGGCGCCTGCTTAGAAGGACGCTGATGCGCTACGTCA
  ATCTCACCTCCCTGCTCATCTTTCGCTCGGTGAGCACTGCTGTGTACAAAAGATTTCCCA
  CAATGGACCACGTGGTTGAAGCAGGTTTTATGACAACAGATGAAAGGAAATTATTCAACC
  ACCTCAAGTCTCCTCATCTGAAATATTGGGTTCCATTCATCTGGTTTGGAAATCTTGCAA
  CTAAAGCCCGGAATGAAGGTAGAATCAGAGACAGTGTTGATCTGCAATCATTGATGACTG
  AAATGAATCGATACCGCTCTTGGTGCAGCCTCTTATTCGGTTATGACTGGGTTGGGATTC
  CGCTGGTTTACACCCAGGTAGCAGAGCAGCTTATCAACCCTTTTGGAGAAGATGATGATG
  ATTTTGAACTAACTGGTGCATTGACAGAAATTTGCAGGTCTCTCTTTTAGCTGTGGACGA
  NATGCACATGAGCTTACCCAAGATGAAGAAGGACATTTACTGGGACGATTCTGCTGCTCN
  GCCACCATACACATTGGCAGCTGCTGACTACTGCATACCCTCATTTNCTGGGTCAACAGT
  CCAGATGGGGCTGTCTGGGGTCGACTTTCTGACNNAGAGTGCTGTGGNATATGAAAGCAT
  GGCATCGGCATTCATGATAGAAAATA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_152439 unedited
  TTTTGGGGTTATTTTATTTCTAAGACCTATGTAGTCAAGTGCCATCATATGACAAATGGT
  AAGTGCAGCAGTCGTAAGGCATGGCCTAGGCACTTGGGAGCCCACGACAAACAGCTGTCC
  TGAGAGCTCCCTGGGAGGAGTACCAACATCCGATCCCCATTATGCAGCTCTGGACCCCAT
  TAGCCTCCCAGCTCCAGTATCCTGCCCATTCCCAAATGACCCGATAGACACAGTAACTGG
  TCCCGTGTTGCGACACGATTAGGATTTTTGCATAAGAGTTCAAGTTAAACAGATGTGAGT
  CATCTTATTCTTTGGTTCCATAGCATTTGGCTATGCAAATTTCATATTCTCTTGGCTTCG
  TTTTTCTCCAGTGCCCAACACCAAATAGTGGAAGCAGAAAGAAATGTCAATGGCTGCAAG
  GGCACGGGGGGAACCATCACTCCTATATGCCTTCCACTGGAAGTGAGACTGGAAGGGTAT
  CAGGCTGGATTTGTTGACACCTTTGATGATTCTGTAGGAGGCTTTGCCAATGTCTTATAT
  TTTGAAATTCATGGCAAGACATAAGCAACAGATTTGGCAAGAGGAAATATTATAACCTGA
  AAAATGGGACAGATTACTAGAAAAGCAGCACAACCAGGGAGAAGGGAAGGGAAAAAAAGG
  ATGACAGAATAAAAGGAAAAGAGAGAAAAGTAAAAAAGGAAATTGAAGAGAATTAAGTGT
  TCTGGTGCTGATGAAGCTTAAGAATCAGGAAGTGATAATAACAATAATAGTTATAAAAGT
  AGGAATGAGATGGTTAGAAAGCCTCANNACAAAACGTTAGGAAGGAGGGGATCTTNCANN
  GCATANGTGATCCATCTCCTTTCTTATGGCTNNAGANNAAAGAAGAGAANAAGAAGAGAA
  TGAGACCCTGCTGTCTGGGCTTTGGTCTANGGGATGACTTGATCATGN
  
• Restriction Sites: NotI-NotI
• ACCN: NM_152439
• ORF Size: 2901 bp
• Insert Size: 3180
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_152439.1, NP_689652.1
• RefSeq Size: 2901
• RefSeq ORF: 2901
• Locus ID: 144453
• Protein Families: Ion Channels: Other, Transmembrane
• Gene Summary: BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]). [supplied by OMIM, Mar 2008]
  Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream in-frame start codon, and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.