Lamin A (LMNA) (NM_170707) Human Untagged Clone

CAT#: SC101048

LMNA (untagged)-Human lamin A/C (LMNA), transcript variant 1


  "NM_170707" in other vectors (6)

Reconstitution Protocol

USD 760.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol LMNA
Synonyms CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC; LMNL1; MADA; PRO1
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC101048 sequence for NM_170707 edited (data generated by NextGen Sequencing)
ATGGAGACCCCGTCCCAGCGGCGCGCCACCCGCAGCGGGGCGCAGGCCAGCTCCACTCCG
CTGTCGCCCACCCGCATCACCCGGCTGCAGGAGAAGGAGGACCTGCAGGAGCTCAATGAT
CGCTTGGCGGTCTACATCGACCGTGTGCGCTCGCTGGAAACGGAGAACGCAGGGCTGCGC
CTTCGCATCACCGAGTCTGAAGAGGTGGTCAGCCGCGAGGTGTCCGGCATCAAGGCCGCC
TACGAGGCCGAGCTCGGGGATGCCCGCAAGACCCTTGACTCAGTAGCCAAGGAGCGCGCC
CGCCTGCAGCTGGAGCTGAGCAAAGTGCGTGAGGAGTTTAAGGAGCTGAAAGCGCGCAAT
ACCAAGAAGGAGGGTGACCTGATAGCTGCTCAGGCTCGGCTGAAGGACCTGGAGGCTCTG
CTGAACTCCAAGGAGGCCGCACTGAGCACTGCTCTCAGTGAGAAGCGCACGCTGGAGGGC
GAGCTGCATGATCTGCGGGGCCAGGTGGCCAAGCTTGAGGCAGCCCTAGGTGAGGCCAAG
AAGCAACTTCAGGATGAGATGCTGCGGCGGGTGGATGCTGAGAACAGGCTGCAGACCATG
AAGGAGGAACTGGACTTCCAGAAGAACATCTACAGTGAGGAGCTGCGTGAGACCAAGCGC
CGTCATGAGACCCGACTGGTGGAGATTGACAATGGGAAGCAGCGTGAGTTTGAGAGCCGG
CTGGCGGATGCGCTGCAGGAACTGCGGGCCCAGCATGAGGACCAGGTGGAGCAGTATAAG
AAGGAGCTGGAGAAGACTTATTCTGCCAAGCTGGACAATGCCAGGCAGTCTGCTGAGAGG
AACAGCAACCTGGTGGGGGCCGCCCACGAGGAGCTGCAGCAGTCGCGCATCCGCATCGAC
AGCCTCTCTGCCCAGCTCAGCCAGCTCCAGAAGCAGCTGGCAGCCAAGGAGGCGAAGCTT
CGAGACCTGGAGGACTCACTGGCCCGTGAGCGGGACACCAGCCGGCGGCTGCTGGCGGAA
AAGGAGCGGGAGATGGCCGAGATGCGGGCAAGGATGCAGCAGCAGCTGGACGAGTACCAG
GAGCTTCTGGACATCAAGCTGGCCCTGGACATGGAGATCCACGCCTACCGCAAGCTCTTG
GAGGGCGAGGAGGAGAGGCTACGCCTGTCCCCCAGCCCTACCTCGCAGCGCAGCCGTGGC
CGTGCTTCCTCTCACTCATCCCAGACACAGGGTGGGGGCAGCGTCACCAAAAAGCGCAAA
CTGGAGTCCACTGAGAGCCGCAGCAGCTTCTCACAGCACGCACGCACTAGCGGGCGCGTG
GCCGTGGAGGAGGTGGACGAGGAGGGCAAGTTTGTCCGGCTGCGCAACAAGTCCAATGAG
GACCAGTCCATGGGCAATTGGCAGATCAAGCGCCAGAATGGAGATGATCCCTTGCTGACT
TACCGGTTCCCACCAAAGTTCACCCTGAAGGCTGGGCAGGTGGTGACGATCTGGGCTGCA
GGAGCTGGGGCCACCCACAGCCCCCCTACCGACCTGGTGTGGAAGGCACAGAACACCTGG
GGCTGCGGGAACAGCCTGCGTACGGCTCTCATCAACTCCACTGGGGAAGAAGTGGCCATG
CGCAAGCTGGTGCGCTCAGTGACTGTGGTTGAGGACGACGAGGATGAGGATGGAGATGAC
CTGCTCCATCACCACCACGGCTCCCACTGCAGCAGCTCGGGGGACCCCGCTGAGTACAAC
CTGCGCTCGCGCACCGTGCTGTGCGGGACCTGCGGGCAGCCTGCCGACAAGGCATCTGCC
AGCGGCTCAGGAGCCCAGGTGGGCGGACCCATCTCCTCTGGCTCTTCTGCCTCCAGTGTC
ACGGTCACTCGCAGCTACCGCAGTGTGGGGGGCAGTGGGGGTGGCAGCTTCGGGGACAAT
CTGGTCACCCGCTCCTACCTCCTGGGCAACTCCAGCCCCCGAACCCAGAGCCCCCAGAAC
TGCAGCATCATGTAA

Clone variation with respect to NM_170707.2
861 t=>c;1338 t=>c
>OriGene 5' read for NM_170707 unedited
GGATTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCGCACCTACA
CCAGCCAACCCANATCCCGAGGTCCGACAGCGCCCGGCCCAGATCCCCACGCCTGCCAGG
AGCAAGCCGAGAGCCAGCCGGCCGGCGCACTCCGACTCCGAGCAGTCTCTGTCCTTCGAC
CCGAGCCCCGCGCCCTTTCCGGGACCCCTGCCCCGCGGGCAGCGCTGCCAACCTGCCGGC
CATGGAGACCCCGTCCCAGCGGCGCGCCACCCGCAGCGGGGCGCAGGCCAGCTCCACTCC
GCTGTCGCCCACCCGCATCACCCGGCTGCAGGAGAAGGAGGACCTGCAGGAGCTCAATGA
TCGCTTGGCGGTCTACATCGACCGTGTGCGCTCGCTGGAAACGGAGAACGCAGGGCTGCG
CCTTCGCATCACCGAGTCTGAAGAGGTGGTCAGCCGCGAGGTGTCCGGCATCAAGGCCGC
CTACGAGGCCGAGCTCGGGGATGCCCGCAAGACCCTTGACTCAGTAGCCAAGGAGCGCGC
CCGCCTGCAGCTGGAGCTGAGCAAAGTGCGTGAGGAGTTTAAGGAGCTGAAAGCGCGCAA
TACCAAGAAGGAGGGTGACCTGATAGCTGCTCAGGCTCGGCTGAAGGACCTGGAGGCTCT
GCTGAACTCCAAGAGGCCGCACTGAGCACTGCTCTCAGTGAGAAGCGCACGCTGGAGGGC
GAGCTGCATGATCTGCGGGGCCAGGTGGCCAAGCTTGAGGCAGCCCTAGGTGAGGCCCAG
AAAGCACTTCAGGATGAAATGCTGCGGCGGGTGGATGCTGANAACCAGCTGCACACATTG
AGGAGGACTGGACTCCAGAAGACATCC
>OriGene 3' read for NM_170707 unedited
ACATTAGAGTCGAGTTTTTTTTTTTTTTTTTTGCTTGTGTTTTTCCTTCGTATAAAACCA
CTGTAGAAAATAACTTCTCTTAGAAAAAAAAATACAGAAGAAAAAAACCAAAGGGTTATT
TTTCTTTGGCTTCAAGCCCCCTCCCATGAGGTGCAGGGCAGGGGGTGGGCATGAGGTGAG
GAGGACGCAGGAAGCCTCCACCCCCACCCCTGCCTGGCAGGTCCCAGATTACATGATGCT
GCAGTTCTGGGGGCTCTGGGTTCGGGGGCTGGAGTTGCCCAGGAGGTAGGAGCGGGTGAC
CAGATTGTCCCCGAAGCTGCCACCCCCACTGCCCCCCACACTGCGGTAGCTGCGAGTGAC
CGTGACACTGGAGGCAGAAGAGCCAGAGGAGATGGGTCCGCCCACCTGGGCTCCTGAGCC
GCTGGCAGATGCCTTGTCGGCAGGCTGCCCGCAGGTCCCGCACAGCACGGTGCGCGAGCG
CAGGTTGTACTCAGCGGGGTCCCCCGAGCTGCTGCAGTGGGAGCCGTGGTGGTGATGGAG
CANGTCATCTCCATCCTCATCCTCGTCGTCCTCAACCACAGTCACTGAGCGCACCAGCTT
GCGCATGGCCACTTCTTCCCCAGTGGGAGTGATGAGAGCCGTACGCAGGGCTGTTCCGCA
GCCCCAGTTGTTCTGTGCCCTTCACACCAGGTCGGTAAGGGGGCTGTGGGTGGCCCCAAC
TCCTTGCAGCCAGATCGTNACCACCTGCCCACCCTTCAGGGTGAACTTTGGTGGGGAACG
GTAATTACCAAGGGATCATCTCCCATTCCGCCCCTTGATTTGGCCAATGCCAATGGAATG
GGCCTAATTGGACTTGTTGCCCCACCGGACACAATTGGCTCTCCCGTCCTCTTCTTTCCG
GCCCTCCCCCCCCCATCGGTCGTGTCTGTATACACCCCTTGCGCCCTCACAGTCCTCCCA
TGTGCCCCTTTCCGGACCCTTCGCCACATTCTGTTTGCGCCCCCGCCACAGAAACACGTT
TTCTCCCCCCAG
Restriction Sites NotI-NotI     
ACCN NM_170707
Insert Size 2560 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_170707.1, NP_733821.1
RefSeq Size 3181 bp
RefSeq ORF 1995 bp
Locus ID 4000
Cytogenetics 1q22
Protein Families Druggable Genome
Protein Pathways Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)
Gene Summary 'The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]'
Transcript Variant: This variant (1) encodes isoform A. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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