EVER2 (TMC8) (NM_152468) Human Untagged Clone

CAT#: SC101329

TMC8 (untagged)-Human transmembrane channel-like 8 (TMC8)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TMC8
• Synonyms: EV2; EVER2; EVIN2
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_152468, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGCTGCTGCCGCGGTCGGTGTCATCGGAGCGGGCCCCTGGGGTGCCGGAGCCGGAGGAGCTGTGGGAGG
  CAGAGATGGAGCGGCTGCGCGGCTCTGGGACGCCCGTGCGCGGGCTGCCCTATGCCATGATGGACAAGCG
  CCTCATCTGGCAGCTGCGGGAGCCCGCGGGGGTGCAGACCTTGCGCTGGCAGCGGTGGCAGCGCCGGCGG
  CAGACGGTGGAAAGGCGCCTGCGGGAGGCAGCGCAGCGGCTGGCCCGGGGCCTTGGGCTCTGGGAGGGGG
  CGCTCTACGAGATCGGGGGCCTCTTCGGCACAGGAATTCGGTCCTACTTCACCTTCCTCCGCTTCCTGCT
  GCTACTCAACCTGCTGAGCCTGCTGCTCACCGCAAGCTTCGTGCTGCTGCCCCTGGTCTGGCTCCGCCCC
  CCTGACCCAGGCCCCACCCTGAACTTGACCCTCCAGTGCCCTGGTAGCCGCCAGTCCCCGCCTGGCGTTT
  TGAGGTTCCACAATCAACTTTGGCATGTTTTGACTGGCAGGGCCTTCACCAACACCTATCTCTTCTACGG
  TGCGTACCGAGTGGGGCCGGAGAGCAGCTCCGTGTACAGCATCCGCCTGGCCTACCTCCTCAGCCCGCTG
  GCCTGCCTGCTCCTCTGCTTCTGTGGGACTCTGCGGCGGATGGTGAAGGGGCTGCCGCAGAAGACTCTGC
  TGGGTCAGGGCTATCAGGCGCCTCTCAGCGCCAAGGTCTTCTCCTCATGGGACTTCTGCATCCGGGTGCA
  GGAAGCAGCCACCATCAAGAAGCATGAGATCAGCAACGAGTTCAAGGTGGAGCTGGAGGAGGGCCGTCGC
  TTCCAGCTGATGCAGCAGCAGACCCGGGCCCAGACGGCCTGCCGCCTGCTCTCCTACCTGCGGGTCAACG
  TACTCAACGGGCTCCTGGTGGTTGGGGCCATCAGCGCCATCTTCTGGGCTACCAAGTACTCACAGGACAA
  CAAGGAGGAGTCCCTGTTTCTGCTGCTCCAGTACCTGCCCCCTGGGGTCATCGCCCTGGTCAACTTCCTG
  GGTCCCCTGCTGTTCACATTTCTGGTCCAGCTGGAGAACTACCCTCCCAACACGGAGGTCAACCTCACTC
  TGATCTGGTGCGTGGTGCTGAAGCTGGCCAGCTTGGGGATGTTCTCCGTCTCCCTGGGTCAGACCATACT
  GTGCATTGGCAGAGACAAGAGCAGCTGTGAGTCCTACGGCTACAACGTTTGTGACTATCAGTGCTGGGAG
  AACTCCGTGGGGGAGGAGCTGTACAAGCTGAGTATCTTCAACTTCCTCCTCACCGTGGCCTTCGCCTTCC
  TGGTCACCCTGCCTCGGAGGCTGCTGGTGGACCGGTTCTCAGGCCGGTTCTGGGCCTGGCTGGAACGGGA
  GGAGTTCCTGGTCCCCAAGAATGTGCTGGACATCGTGGCGGGGCAGACGGTCACCTGGATGGGCCTCTTC
  TACTGCCCCCTGCTGCCCCTGCTGAATAGCGTCTTCCTCTTCCTCACCTTCTACATCAAGAAGTACACCC
  TCCTGAAGAACTCCAGGGCATCTTCGCGGCCCTTCCGTGCCTCCAGCTCCACCTTCTTCTTCCAGCTAGT
  GCTCCTCCTGGGCCTGCTTCTGGCTGCAGTGCCCCTGGGCTATGTGGTCAGCAGCATCCACTCCTCCTGG
  GACTGCGGCCTCTTCACCAACTACTCAGCACCCTGGCAAGTGGTCCCGGAGCTGGTGGCCCTTGGGCTCC
  CGCCCATTGGCCAGCGTGCCCTCCACTACCTGGGCTCCCACGCCTTCAGCTTCCCCCTCCTCATCATGCT
  CAGCCTTGTCCTGACGGTGTGCGTCTCCCAGACCCAGGCCAATGCCAGGGCCATCCACAGGCTCCGGAAG
  CAGCTGGTGTGGCAGGTTCAGGAGAAGTGGCACCTGGTGGAGGACCTGTCGCGACTGCTGCCGGAGCCAG
  GCCCGAGCGACTCTCCGGGCCCCAAGTACCCTGCCTCCCAAGCTTCGCGCCCGCAGTCCTTCTGCCCCGG
  ATGCCCATGCCCTGGCTCCCCGGGCCACCAGGCCCCGCGGCCGGGCCCCTCCGTCGTGGATGCCGCGGGA
  CTGCGTTCCCCTTGCCCTGGACAGCACGGTGCCCCGGCCTCCGCCCGCAGATTCCGCTTCCCCAGCGGCG
  CGGAGCTGTAA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_152468 unedited
  AGTATTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACCAGCCAGGNACTT
  GGTCCCTAGGTCCCCAGATGGGGAGACTGAGGCCGTGGCTGTGTGTCCCTCTGAGAGTTG
  GAGCGGGGCTGGGCCCGAATTCGACCCCAGCAGGATTCTCTCTCATTTCTGAGCCCCGGA
  GGTGGCAGAGCGGCAGACCCGGGCAAGTGAACCCTAGGGCTGCAGGAGCCCAGGCCCCGA
  CGCCGGCGCAGAGGGGACGGAAGGGCCCGCCCCCAGCCCAGCGTGCACAGAGGCCATAGC
  CAAGGCCTTAAGGCTCATCCAACCGGGGACTCATATCCCCCCCACCGGCAGCCCGGCGCC
  CCAGCCTCTACCCGTGCCCGCCGAGATGCTGCTGCCGCGGTCGGTGTCATCGGAGCGGGC
  CCCTGGGGTGCCGGAGCCGGAGGAGCTGTGGGAGGCAGAGATGGAGCGGCTGCGCGGCTC
  TGGGACGCCCGTGCGCGGGCTGCCCTATGCCATGATGGACAAGCGCCTCATCTGGCCTCT
  TCGGCACAGGAATTCGGTCCTACTTCACCTTCCTCCGCTTTCTGCTGCTACTCAACCTGC
  TGAGCCTGCTGCTCACCGCAAGCTTCGTGCTGCTGCCCCTGGGCTGGCTCCGGCCCCCTG
  ACCCAGCCCCACCCTGAACTTGACCCTTCAGTGCCCTGGTAGCCGNCACGTCCCGCCTGG
  CGTTTTGAAGTTCCACACTCAACTCTGGCATGTTTTGACTGTCAGGGCCTTTACCACCAC
  TAACTCTTCTACCGTGCGTACCGAGTGGGCCCGGAAAGCANTTCGTGTACAGCATTCGGC
  TGGGCTACTCCCTAGACCGCTGGCTGCCTGCTCTTTGTTTTGTGGACTCTCCGCCGAGGT
  GAAGGGCTGCCCCAAAAACTTGTTTTTCAGGGTTTAAGCGCCTTATGCCCAGTGTTCCTC
  ATGGACTT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_152468
• ORF Size: 4419 bp
• Insert Size: 2500
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_152468.3, NP_689681.2
• RefSeq Size: 4419
• RefSeq ORF: 4419
• Locus ID: 147138
• Protein Families: Transmembrane
• Gene Summary: Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008]