Caspase 3 (CASP3) (NM_032991) Human Untagged Clone

CAT#: SC101958

CASP3 (untagged)-Human caspase 3, apoptosis-related cysteine peptidase (CASP3), transcript variant beta


  "NM_032991" in other vectors (7)

Reconstitution Protocol

SC101958 is the updated version of SC125424.

USD 310.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol CASP3
Synonyms CPP32; CPP32B; SCA-1
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC101958 sequence for NM_032991 edited (data generated by NextGen Sequencing)
ATGGAGAACACTGAAAACTCAGTGGATTCAAAATCCATTAAAAATTTGGAACCAAAGATC
ATACATGGAAGCGAATCAATGGACTCTGGAATATCCCTGGACAACAGTTATAAAATGGAT
TATCCTGAGATGGGTTTATGTATAATAATTAATAATAAGAATTTTCATAAAAGCACTGGA
ATGACATCTCGGTCTGGTACAGATGTCGATGCAGCAAACCTCAGGGAAACATTCAGAAAC
TTGAAATATGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATG
CGTGATGTTTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTTGTTTGTGTGCTTCTGAGC
CATGGTGAAGAAGGAATAATTTTTGGAACAAATGGACCTGTTGACCTGAAAAAAATAACA
AACTTTTTCAGAGGGGATCGTTGTAGAAGTCTAACTGGAAAACCCAAACTTTTCATTATT
CAGGCCTGCCGTGGTACAGAACTGGACTGTGGCATTGAGACAGACAGTGGTGTTGATGAT
GACATGGCGTGTCATAAAATACCAGTGGAGGCCGACTTCTTGTATGCATACTCCACAGCA
CCTGGTTATTATTCTTGGCGAAATTCAAAGGATGGCTCCTGGTTCATCCAGTCGCTTTGT
GCCATGCTGAAACAGTATGCCGACAAGCTTGAATTTATGCACATTCTTACCCGGGTTAAC
CGAAAGGTGGCAACAGAATTTGAGTCCTTTTCCTTTGACGCTACTTTTCATGCAAAGAAA
CAGATTCCATGTATTGTTTCCATGCTCACAAAAGAACTCTATTTTTATCACTAA

Clone variation with respect to NM_032991.2
>OriGene 5' read for NM_032991 unedited
TTCAGCATTTTGTAATACGACTCACTTATAGGGCGGCCGCGAATTCGCACGAGGGCGGTT
GTGGAAGAGTTTCGTGAGTGCTCGCAGCTCATACCTGTGGCTGTGTATCCGTGGCCACAG
CTGGTTGGCGTCGCCTTGAAATCCCAGGCCGTGAGGAGTTAGCGAGCCCTGCTCACACTC
GGCGCTCTGGTTTTCGGTGGGTGTGCCCTGCACCTGCCTCTTCCCCCATTCTCATTAATA
AAGGTATCCATGGAGAACACTGAAAACTCAGTGGATTCAAAATCCATTAAAAATTTGGAA
CCAAAGATCATACATGGAAGCGAATCAATGGACTCTGGAATATCCCTGGACAACAGTTAT
AAAATGGATTATCCTGAGATGGGTTTATGTATAATAATTAATAATAAGAATTTTCATAAA
AGCACTGGAATGACATCTCGGTCTGGTACAGATGTCGATGCAGCAAACCTCAGGGAAACA
TTCAGAAACTTGAAATATGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTG
GAATTGATGCGTGATGTTTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTTGTTTGTGTG
CTTCTGAGCCATGGTGAAGAAGGAATAATTTTTGGAACAAATGGACCTGTTGACCTGAAA
AAAATAACAAACTTTTTCAGAGGGGATCGTTGTAGAAGTCTAACTGGAAAACCCAAACTT
TTCATTATTCAGGCCTGCCGTGGTACAGAACTGGACTGTGGCATTGAGACAGACAGTGGT
GTTGATGATGACATGGCGTGTCATAAATACCAGTGGNAGCCGACTTCTGTATGCATACTC
ACAGCACTGGTTATTATCTNGGCGAATTCAAGGAGGCTCCTGGNTCTCCAGTCGCTTGTG
CCTGCTGAAACATATGCCGACAGCTTGAATTT
>OriGene 3' read for NM_032991 unedited
GGCCGCAATCTAGNATCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTAAGTTTGAAT
GTATATTTTGAAATAAAAATGGGAAAATAACAAATTTGTACAAAATTGTCACATTAGAAA
CACACTTTAAGATACCATTACATGCTATGTGTATTTACAAAAGTTACAGGTCTAGTAAGA
AAAAAGAAACTGTCATTGACAAATGCGAGCTCATTTTTTGAGCAACAAGAAATCTCCCGT
GAAATGTCATACTGACAGCCAGTGAGACTTGGTGCAGTGACGGCTCCGCACCTGCTGAGG
CCTGGAGCCTGCCTCCCGGGCTGAGTGCTCAGCTCTGGCCTCCGGCTGGATGCCGTCTAA
AGTCCTATGTGCTCATAGGTCTTTTTCTTTCAGTAAACAGTATAAAACATTACTATTTTC
CTTTGATTGGAAACTTCAACAGAAAATAACATACTTAAGAATTTTGCTACAAAGAGTACT
ATGATTTTTATTGCCTCACCACCTTTAGAACATTTCCACTTCACAAGTTTCTGATTTGCT
TCACTTTCTTACTTGGCGATGGCGCCCTGGCAGCATCATCCACACATACCAGTGCGTATG
GAGAAATGGGCTGTAGGCCCTTCCTGCGTGGTCCATGGCTCTGCCTTCATGGAACAGGCT
GAGTCATGTCTCTGCTCAAGCTCAAACCATCTACTCTCAAGTTACAGGCAGCTCAGCCCA
TTCATTTATTGCTTTCCTTATATTCCACTGTTTATTATTTAAAGTGTATTTTCATATGTN
CCTATAGAAATTATTCACATTACCTGGCTAATAATCACAGTTTGGGGTTTTTATATAATA
GCTCTTCAGAATATTGCTGGGTTATGAAGCTCACTGATATGCTAGGGACAATANAANATT
TATGCTGTAGATCAAGGCATGTACACCTCAGTAAACTCACCTTATGATGTAGTTACCTTA
AGCAGTATCTGCCACTTTT
Restriction Sites NotI-NotI     
ACCN NM_032991
Insert Size 2680 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_032991.2, NP_116786.1
RefSeq Size 2522 bp
RefSeq ORF 834 bp
Locus ID 836
Cytogenetics 4q35.1
Domains CASc, ICE_p10, ICE_p20
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Protease
Protein Pathways Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Epithelial cell signaling in Helicobacter pylori infection, Huntington's disease, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, p53 signaling pathway, Parkinson's disease, Pathways in cancer, Viral myocarditis
Gene Summary 'The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]'
Transcript Variant: This variant (2, also known as beta) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).

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