CBL (AK092300) Human Untagged Clone

CAT#: SC102986

(untagged)-Human cDNA FLJ34981 fis, clone OCBBF2000982


Reconstitution Protocol

USD 660.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol CBL
Synonyms C-CBL|CBL2|FRA11B|NSLL|RNF55
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for AK092300, the custom clone sequence may differ by one or more nucleotides


TCAGGACCCAAAGATCCTTTAGTCAGTTGTTGGGTCTTCCAAGAGCCAGACATTAATACAGATTGAACTC
CATCAGTCCCCTAATTGTCAGCCTTTACCTCCCTCCCAGAGCAAGGAGTTTAGGGATTCTAAAGCTTAGT
GTCCACACATCATTCTACCAGACCTTAGAGCTTTAGAAGCTCAATCTAAAATACTGTAACTCAGCATAAA
CTATTACTATCACTCCTTTGAACTCAGTCTCCATGAGCAGTGTTTTGTTGGAAATACATAGAACGGCTTA
ATGCCTAGAGGGTGGTGGATAGTGAAGGACGGTCAAGGTTATATTTTTGACTGCTTAGGGATTCTTTGGA
TACAAGAAACAGAAATGTTCAAGCGGAATAAAGGAGGGAGTGGAGTTGTGGTAAGGATGCAGGGTATTTC
GCAGAACCCAGGACGGGAAGTGCCTTTGGTTCTTGGGTGGAGCTGGAACTGCAGAGCTTTGCACCTAGTC
CTTTCTCCCGCTTCACAGTCTGCTTATGGTATATGTGGCCCCCAAATAGGCACTCTAGTCCTCAAGTCTA
CACCACCTTCCAACTCTGGGGATCACCATGAACAAATTCTCAATTTCCCATACTTAATTTTTTTTTTTTT
TGAGATGGAGTCTCGCTGTGTCGCCCAGGCTGGAGTGCAGTGGTGCAGTCTCAACTCACCACAACCTCCG
CCTCCCAGGTTCAAGCAGTTCTCTGCCTCAACCTCCCGAGTAGCTGGGATTACAGGCGCCTGCCACCATG
CCCAGCTAATGTTCATATTTTTAGTAGAGACAGGGTTTCACCGTCTTGGCTAGGCTGGTCTTGAACTCCT
GACCCTCATGATCCACCCACCTCGGCCTCCCAAAGTGCTAAGATTACAGGCGTGAGCCACCGCGCCCGGC
CCATACTTCGTATTCTTAAAAAAAACTACACTCAGCCCAGCACATTGATCAAGTATCTATCTCTGAGCAG
TTGGCCTTGCCAGGGAGAGCAGAGATGTGGCAGGCTCCTTCAGCTGGAGACAGGGAGCTTCTCAGAGAAG
TGAGCAGAGACTCCACAGACACCCTAAAAAGGCTTCTACTCAAGAAGTAAAGCCACTACTCCTGCCTTTT
TGCTTAGTGGACAGGAAGGCACAGGAGTTTGTCTGGGACATCATAGAAATTCTTAGGTTTAACTTAATTC
TGGTCATTGTCTTCTTTATTTCCTGTTTTTCTTCCCTTTGTCAGTCTTCGCATCCAAGATTTCTTCCCTC
CCTCTTGTGGGCCAGCCTGTCCTGTTCCAGAGCTAGCCTGTTCCTGGGTAGCCTTCCTTAGCCTCCATTC
AGCCTCAGGTCTTTTGCCTTCTTCCGTGTTTATTTAGAGAGCAGAATCTAATAACGGGTTCCACTGTAGC
CACTATCCATGGACTTCTGGGTCCTCTTCAGGTTTGAGTGCTTGAAAATGTTCATTCTCTGGGCTTGTGG
CCTGTCTCCTCCACTCTCCTCCTCACCCTCTCGCTCCTTCCTGTGTGAGGGCCGCTCTGCAGTAATGTTC
TCAGGCAAGCCTTCCTAGGCACCTCAGAAACTACTTTGCCAGAGCCAGTAAGAATATATAATATTGGAGC
AGTTGCCAGGATAGAAATTAAATATAGATTCCAGTTTAGGATAGAGTTTTTACCGAGAGCTCTTTAGACA
GTATACCTGTGTCTTCTCTGGCAATTGCTTTCATTTTAGTCCTATATAAAAGCTTTCCTTTTCTGTTTTT
TTTTAAAACTATGCTTTTGCTTGCCTAAATCTTTTGATCTTATATTTCTCTCATCTCAGAGCCTGTCCTG
AGTTGTAAGGTATTTCATACTGCCTTACTTAAAAGTTTTTTAAACTACTAGAGTCATTTGATACACACAG
AAGTTACCTAATAATCCAAAGATGTCCATCAAGGGAGGAAGGGTGGGTCATCAGACTTTGCCTTTGATGT
TGTAGACTAGGCTCCTGAGTTAAGCAGCAGAGGGACAGCAGTGCCATGTGCCTTCACTGTGTCCCAGGAA
ATCTGGGTTGGTTCCAGTGGGAAATACCAGTATTTCTTGGTTCTGGAAAGTAGCAAAAGAGTAGGAGATG
GGGAAATAGGGATGGGGAGAGCAAGCCCCGCATGTCCATGGCGAGTCAGGTGGGGAGCACGGGTGGAAGG
GCCGGCTGTTGACAGACAGACTAAGCTGTGTGGTGCTCTTGCCGCCCCTTCCTGGGTACAGAGCTTGAGA
AAAATGCAGCCGACCACTCCCTGTGTTTGTACAGAGCAAAGCCCAAAAGCCAACCTCAGATCTCCTGATT
TGGCAGCTGAAGAAATCAGCAGAGTCCTGATTGCCTGATTCAGTCCCAAAAATGAATGTCAGGCCCCGCC
CCCTCCCCACCAACATTGCCTCTCCTACATTCTCCTTCTGCCCCTAAATCAGACAGGAGGCCAGAGAGGA
GTATTGCTCAATGCGTGCTATGTGCAACTCCTCAGGCCTTGTGCCACCTCCATGCTGAGCCCTGAAGCAG
GGTGTCCTGGGTGCCTGTGTGTCAGCTCCCTCCTCTCTACCTACCTCTGACCTTCTTGTGGGTGAGGGTG
GCCATGCTTATGGCCATCTTAAAACTGGAGAGGCAGAGAACTACTTATGAGTCTGTAGACCACGTGTTGT
CTTCCATGGCCTGTTTCTCCTGCTGTCTGGGTGAGTGAGCCTGCAACGCAATGCCCATGAGAGTAAATGC
CTCCTGACCTACCCTGCTCAGCACTGTTCTAGTGTCTTGGCCTTGAAAGAAAAGCCTGACTTCCTGCTGA
CACATGTGGTAGGGGCATGGCAGCTATGAGGCACCTCCTACGTCTGTTTTCTGGCTGTGGTGACTTGGGA
TTTTTAACCTTATATATCTTTTTCCTTTACTCAAAACAAAACAATTTTTAGCACACTG


>OriGene 5' read for AK092300 unedited
TCAGATTTTGTAATACGACTTACTATAGGGCGGCCGCGAAATTCGCACGAGGCTTTGATA
ATGCCTGGGAGATTCCTTGGTGTAAGTGTCATGGATACCGACTGTTTTTATGTTGGAATT
TGTTCCAACATAATTAGAATCTGTTTGGTGAGTTGAAAGGTAAGTTGGCTCAGAGTTGCA
CAGTAGGGCATTAAATGTTTAAGCAAAGCATCTGCCCACACTCCCCTTTCCAATCTAGTG
CCTTCCTTGAACTTTTTCCTGAGCTGCTACGTCCCTAATCCCCCTTGTTGGGAGGATTTT
CGTATCACCCTTATGGGACCTGTCACCATGTCCTGTACTATTTGGAATTGGTTTTCCAGT
CTTTCAACAACCGTTGTGGCTAACTATGTTTTAGAAGGGCTGGAGGTGTGGGCCCTGTCT
TCGGGTCTCAGGACCCAAAGATCCTTTAGTCAGTTGTTGGGTCTTCCAAGAGCCAGACAT
TAATACAGATTGAACTCCATCAGTCCCCTAATTGTCAGCCTTTACCTCCCTCCCAGAGCA
AGGAGTTTAGGGATTCTAAAGCTTAGTGTCCACACATCATTCTACCAGACCTTAGAGCTT
TAGAAGCTCAATCTAAAATACTGTAACTCAGCATAAACTATTACTATCACTCCTTTGAAC
TCAGTCTCCATGAGCAGTGTTTTGTTGGAAATACATAGAACGGCTTAATGCCTANAGGGT
GGTGGATAGTGAAGGACGGTCAAGGTTATATTTTTGACTGCTTANGGATTCTTTGGATAC
AAGAACAGAAATGTTCAAGCGGAATAAAGNAGGAGTGGAGTTGTGGTAGGATGCAGGGTA
TTTCGCAGACCCAGACGGGAAGTGCCTTTGTCTTGGTGGAGCTGAACTGCAAGCTTGCAC
TAGTCTTTCTCCGCTACAGCTGCTATGGATATGTGCCCCAAAGCACCTATNCTCAGTTCA
CACTTCATTTGGG
>OriGene 3' read for AK092300 unedited
GCTCATTTATGNACCGCGGCACGCAATTCTNANGATCGAGTTTTTTTTTTTTTTTTTTCA
GTGTGCTAAAAATTGTTTTGTTTTGAGTAAAGGGAGAAAAGATATATAAGGTTAAAAATC
CCAAGTCACCACAGCCAGAAAACAGACGTAGGAGGTGCCTCATAGCTGCCATGCCCCTAC
CACATGTGTCAGCAGGAAGTCAGGCTTTTCTTTCAAGGCCAAGACACTAGAACAGTGCTG
AGCAGGGTAGGTCAGGAGGCATTTACTCTCATGGGCATTGCGTTGCAGGCTCACTCACCC
AGACAGCAGGAGAAACAGGCCATGGAAGACAACACGTGGTCTACAGACTCATAAGTAGTT
CTCTGCCTCTCCAGTTTTAAGATGGCCATAAGCATGGCCACCCTCACCCACAAGAAGGTC
AGAGGTAGGTAGAGAGGAGGGAGCTGACACACAGGCACCCAGGACACCCTGCTTCAGGGC
TCAGCATGGAGGTGGCACAAGGCCTGAGGAGTTGCACATAGCACGCATTGAGCAATACTC
CTCTCTGGCCTCCTGTCTGATTTAGGGGCAGAAGGAGAATGTANGATAGGCAATGTTGGT
GGGGAGGGGGGCGGGGCCTGACATTCATTTTTGGGACTGAATCANGCAATCAGGACTCTG
CTGATTTCTTCAGCTGCCAAATCAGGAGATCTGAGGTTGGCTTTTGGGCTTTGCTCTGTA
CAAACACAGGGAGTGGTCGGCTGCATTTTTCTCAAGCTCTGTACCCAGGAAGGGGGCGGG
CAGAGCACCACACAGCTTAATCTGTCTGTCAACAGCCGGGCCTGCCACCCGTGCTCCCCA
CTGACTCGCATGGACATGCGGGGCTTGCTCTCCCATCCTATTTCCCATCTNCTACTCTTT
GCTACTTTCA
Restriction Sites NotI-NotI     
ACCN AK092300
Insert Size 3500 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq AK092300.1
RefSeq Size 2928 bp
RefSeq ORF 2928 bp
Locus ID 867
Cytogenetics 11q23.3
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Chronic myeloid leukemia, Endocytosis, ErbB signaling pathway, Insulin signaling pathway, Jak-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Ubiquitin mediated proteolysis
Gene Summary 'This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016]'

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