NUMBL (AK096566) Human Untagged Clone

CAT#: SC103387

(untagged)-Human cDNA FLJ39247 fis, clone OCBBF2008520


Reconstitution Protocol

USD 660.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol NUMBL
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for AK096566, the custom clone sequence may differ by one or more nucleotides


CACACTCTTGCACAGTCTGACAACACACACAGACCCACATTTCTACAGACGACAGCCACACTTTCACAGA
CAGCACCCGCGGGGCCAGGCTCTCACAGGGAGCTACGGTTGTGTACAAACATGCACACAGTCTCACAAAG
AACACCCAGCACTCTCTCAGGCAACAGTCACACCCTTACAAATAACCCTCATGAAAACACTCTCAAAGAC
AACCTCATGTTCCCACACACCCTAACGGATGCACCACTGCACACAGATACACCCTCTGTGCAATACCCAC
ACACCCACACTCTAAGGCAACAGCCACAGTCACACAGGCTCACCGCCAACAGCTGCACTCTTGGACACAG
ACAGTCTTGTAGATCCCTCAGATGCACTCTCCGAGGCAATGTCATCACAGACAATAGCCACACCTTCACA
CAGAGACATAGCTACATGGATAACAGCCATGGACACACCCTTTGAAAGACGACAGCCTCATCTCAAACAC
AGACACACCCTCACAGGCAACAGGCACTGAGCCACAAGTTCTCATAGACAACAACGGCACTCTCGGATAT
AGACAGCAGACACACACTCACAACCACTCTCAGACATCGATGCCCTTCAGCAACAACCTTCAGGGCCTCA
GACTCACAGACAACAACCACACTTTTGGATGCATCCCTCACGGACAGCATTCACAGATGCACACTATCCT
ACACCATTCTCAGACATGCGTTCTTCCAGACAGCCTTCAGAAACACACTCACAGACATTACTTGCCTGCT
CAGATATAGAGCCCCTCATAGACAGCGTTCCAGAACATACCATTGCACACTTACTTACACACACACACAC
ACACACACATCCCCCTCTGCTGTTGGTGCTCCCAGTCCTGGGACTGTCAGGATGGCTGATCAGTGAAGAC
TGTCCTAGTGGCTGGCCACCTCCACACCCACTCCACACACCCACAGCCCTGCCTCTGACAGTCATCAGTG
CAAGGCCCCAGAAGCCTTGCCTGGGGACTAGACACAGTTGTCACAGAATGGCTGTGTCTCAGAGTTCCAG
AGACAAGCCACCATCCCCCATACCCCATGCACCTGACTCCTGCACCCCTGACCCATGCAATTCCCAACTC
CTCTGCTGCCCTCTGATCACCCCACTGCCTGACTCTCATACCCCTAAAACCCCTGACCGTGCGGCCCCTG
ACTTCTATGCCCTCTAGCCCCCATGCCCTCCTACGTCTGATTTCCCACCCTTTGTGTCCTCACGGCCCTG
GGAATGAGGAAGCATCCACCACATGGACAAGAAGCCCTCCAATGCCCTGAAGCCTGTGCCCCATACCCCC
CACCCCAGACCTCCAGCCCCTTAGCCCCATGGTTCTGAATCCCCAGTGCCCAACTTTCGCACTCCCCTGG
CTTCTGTTGGCTCCTTTCCTCACTGTCCCCTGACTTGAGCTGCTGATCCCATGTGCGCTGCCAACTGACC
CTGTAACCCCGCTTCCAGTTATCTTGTTATCTGACCCCATGCTCCCTGAGCACTGGTCCCTCCCCGTTGA
GCTCCATACCTTCTGACCCCCACCCTTGACCCACATCACTGTCCTGTGTCACCAGACGGGGCGGGCACCA
TGAACAAGTTACGGCAGAGCCTGCGGCGGAGGAAGCCAGCCTACGTGCCCGAGGCGTCGCGCCCGCACCA
GTGGCAGGCAGACGAGGACGCGGTGCGGAAGGGCACGTGCAGCTTCCCGGTCAGGGTGAGTGGGCGCGGC
AGGGTGCGGCGGGGCGAGGGGGACGGGGGCCGCTGTGCTGTGCTGTGCGGGTGCGCGGCCTGGCTGGGAC
ACCAGCCCAAGTCGTTTGAAGTTGGTGTTAAAAAGCGTGAGGCCGGCAGTCCTGGCTATCACGGTGAAAC
CCCGGCTCTACTAGAAATACAACAAATTAGCCTCGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTGGG
GAGGCTGAGACAGGAGAATCGCTTGAACCCGGGAGGCGGAGATTGCAGTGAGCCGAGATAGCGCCATTGC
ACTCCAGCCTGGGCGACAGAGCAGACTCTGTTTC


>OriGene 5' read for AK096566 unedited
TCACAATTGTATACGACTCATATAGGCGGCCGCGAAATTCGCACGAGGCGGTTGTGTACA
AACATGCACACAGTCTCACAAAGAACACCCAGCACTCTCTCAGGCAACAGTCACACCCTT
ACAAATAACCCTCATGAAAACACTCTCAAAGACAACCTCATGTTCCCACACACCCTAACG
GATGCACCACTGCACACAGATACACCCTCTGTGCAATACCCACACACCCACACTCTAAGG
CAACAGCCACAGTCACACAGGCTCACCGCCAACAGCTGCACTCTTGGACACAGACAGTCT
TGTAGATCCCTCAGATGCACTCTCCGAGGCAATGTCATCACAGACAATAGCCACACCTTC
ACACAGAGACATAGCTACATGGATAACAGCCATGGACACACCCTTTGAAAGACGACAGCC
TCATCTCAAACACAGACACACCCTCACAGGCAACAGGCACTGAGCCACAAGTTCTCATAG
ACAACAACGGCACTCTCGGATATAGACAGCAGACACACACTCACAACCACTCTCAGACAT
CGATGCCCTTCAGCAACAACCTTCAGGGCCTCAGACTCACAGACAACAACCACACTTTTG
GATGCATCCCTCACGGACAGCATTCACAGATGCACACTATCCTACACCATTCTCAGACAT
GCGTTCTTCCAGACAGCCTTCAGAAACACACTCACAGACATTACTTGCCTGCTCAGATAT
AGAGCCCCTCATAGACAGCGTTCCAGAACATACCATTGCACACTTGCTTAACACACACAC
ACACACACATNNCCCTTTGCTGTTGGTGCTCCCAGTCCTGGGACTGTCANGATGGCTGAT
CAGTGAAGACTGTNCTAGTGGNTGGNCACTNCACACCACTNCAACACCCACAGNCCTGCC
TNTGAAGTCATAGTGCAAGCCCCAAAGCCCTGCTGGNGACANAACAGTGTCCAGAATGCT
GGTCTCA
>OriGene 3' read for AK096566 unedited
GTACCGCGGCCGCATCTANATCGAGTTTTTTTTTTTTTTTTTTTTTTTTTGAAACAGAGT
CTGCTCTGTCGCCCAGGCTGGAGTGCAATGGCGCTATCTCGGCTCACTGCAATCTCCGCC
TCCCGGGTTCAAGCGATTCTCCTGTCTCAGCCTCCCCAGTAGCTGGGACTACAGGCGCCC
GCCACCACGCGAGGCTAATTTGTTGTATTTCTAGTAGAGCCGGGGTTTCACCGTGATAGC
CAGGACTGCCGGCCTCACGCTTTTTAACACCAACTTCAAACGACTTGGGCTGGTGTCCCA
GCCAGGCCGCGCACCCGCACAGCACAGCACAGCGGCCCCCGTCCCCCTCGCCCCGCCGCA
CCCTGCCGCGCCCACTCACCCTGACCGGGAAGCTGCACGTGCCCTTCCGCACCGCGTCCT
CGTCTGCCTGCCACTGGTGCGGGCGCGACGCCTCGGGCACGTAGGCTGGCTTCCTCCGCC
GCAGGCTCTGCCGTAACTTGTTCATGGTGCCCGCCCCGTCTGGTGACACAGGACAGTGAT
GTGGGTCAAGGGTGGGGGTCAGAAGGTATGGAGCTCAACGGGGAGGGACCAGTGCTCANG
GAGCATGGGGTCAGATAACAAGATAACTGGAAGCGGNGTTACAGGGTCAGTTGGCAGCGC
ACATGGGATCAGCAGCTCAAGTCAGGGGACAGTGAGGAAAAGAGCCCACAGAAGCCAGGG
GAGTGCGAAAGTTGGCACTGGGATTCAGACCATGGGGCTAAGGGGCTGGAGTCTGGGGTG
GGGGTATGGGCACAGGCTTCAGGCATTGGAGGGCTCTTGCCATGTGGGGGATGCTCCTCA
TCCCAGGGCCCTGAAGACACAAGGTGGGAAATAAACTTAGAAGGCATGGGGCTAAGGGAT
AAAATAGGGGCCCACGGCCGGGGTTTATGGGTTAAGATCAGCCCGGGGGATCAGAGCACC
CAAGATTGGGATGCTGGTTCGGT
Restriction Sites NotI-NotI     
ACCN AK096566
ORF Size 2064 bp
Insert Size 2000
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq AK096566.1
RefSeq Size 2064
RefSeq ORF 2064
Locus ID 9253
Protein Pathways Notch signaling pathway
Gene Summary Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. [UniProtKB/Swiss-Prot Function]

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