NUMBL (AK096566) Human Untagged Clone

CAT#: SC103387

(untagged)-Human cDNA FLJ39247 fis, clone OCBBF2008520

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NUMBL
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for AK096566, the custom clone sequence may differ by one or more nucleotides
  
  
  CACACTCTTGCACAGTCTGACAACACACACAGACCCACATTTCTACAGACGACAGCCACACTTTCACAGA
  CAGCACCCGCGGGGCCAGGCTCTCACAGGGAGCTACGGTTGTGTACAAACATGCACACAGTCTCACAAAG
  AACACCCAGCACTCTCTCAGGCAACAGTCACACCCTTACAAATAACCCTCATGAAAACACTCTCAAAGAC
  AACCTCATGTTCCCACACACCCTAACGGATGCACCACTGCACACAGATACACCCTCTGTGCAATACCCAC
  ACACCCACACTCTAAGGCAACAGCCACAGTCACACAGGCTCACCGCCAACAGCTGCACTCTTGGACACAG
  ACAGTCTTGTAGATCCCTCAGATGCACTCTCCGAGGCAATGTCATCACAGACAATAGCCACACCTTCACA
  CAGAGACATAGCTACATGGATAACAGCCATGGACACACCCTTTGAAAGACGACAGCCTCATCTCAAACAC
  AGACACACCCTCACAGGCAACAGGCACTGAGCCACAAGTTCTCATAGACAACAACGGCACTCTCGGATAT
  AGACAGCAGACACACACTCACAACCACTCTCAGACATCGATGCCCTTCAGCAACAACCTTCAGGGCCTCA
  GACTCACAGACAACAACCACACTTTTGGATGCATCCCTCACGGACAGCATTCACAGATGCACACTATCCT
  ACACCATTCTCAGACATGCGTTCTTCCAGACAGCCTTCAGAAACACACTCACAGACATTACTTGCCTGCT
  CAGATATAGAGCCCCTCATAGACAGCGTTCCAGAACATACCATTGCACACTTACTTACACACACACACAC
  ACACACACATCCCCCTCTGCTGTTGGTGCTCCCAGTCCTGGGACTGTCAGGATGGCTGATCAGTGAAGAC
  TGTCCTAGTGGCTGGCCACCTCCACACCCACTCCACACACCCACAGCCCTGCCTCTGACAGTCATCAGTG
  CAAGGCCCCAGAAGCCTTGCCTGGGGACTAGACACAGTTGTCACAGAATGGCTGTGTCTCAGAGTTCCAG
  AGACAAGCCACCATCCCCCATACCCCATGCACCTGACTCCTGCACCCCTGACCCATGCAATTCCCAACTC
  CTCTGCTGCCCTCTGATCACCCCACTGCCTGACTCTCATACCCCTAAAACCCCTGACCGTGCGGCCCCTG
  ACTTCTATGCCCTCTAGCCCCCATGCCCTCCTACGTCTGATTTCCCACCCTTTGTGTCCTCACGGCCCTG
  GGAATGAGGAAGCATCCACCACATGGACAAGAAGCCCTCCAATGCCCTGAAGCCTGTGCCCCATACCCCC
  CACCCCAGACCTCCAGCCCCTTAGCCCCATGGTTCTGAATCCCCAGTGCCCAACTTTCGCACTCCCCTGG
  CTTCTGTTGGCTCCTTTCCTCACTGTCCCCTGACTTGAGCTGCTGATCCCATGTGCGCTGCCAACTGACC
  CTGTAACCCCGCTTCCAGTTATCTTGTTATCTGACCCCATGCTCCCTGAGCACTGGTCCCTCCCCGTTGA
  GCTCCATACCTTCTGACCCCCACCCTTGACCCACATCACTGTCCTGTGTCACCAGACGGGGCGGGCACCA
  TGAACAAGTTACGGCAGAGCCTGCGGCGGAGGAAGCCAGCCTACGTGCCCGAGGCGTCGCGCCCGCACCA
  GTGGCAGGCAGACGAGGACGCGGTGCGGAAGGGCACGTGCAGCTTCCCGGTCAGGGTGAGTGGGCGCGGC
  AGGGTGCGGCGGGGCGAGGGGGACGGGGGCCGCTGTGCTGTGCTGTGCGGGTGCGCGGCCTGGCTGGGAC
  ACCAGCCCAAGTCGTTTGAAGTTGGTGTTAAAAAGCGTGAGGCCGGCAGTCCTGGCTATCACGGTGAAAC
  CCCGGCTCTACTAGAAATACAACAAATTAGCCTCGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTGGG
  GAGGCTGAGACAGGAGAATCGCTTGAACCCGGGAGGCGGAGATTGCAGTGAGCCGAGATAGCGCCATTGC
  ACTCCAGCCTGGGCGACAGAGCAGACTCTGTTTC
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for AK096566 unedited
  TCACAATTGTATACGACTCATATAGGCGGCCGCGAAATTCGCACGAGGCGGTTGTGTACA
  AACATGCACACAGTCTCACAAAGAACACCCAGCACTCTCTCAGGCAACAGTCACACCCTT
  ACAAATAACCCTCATGAAAACACTCTCAAAGACAACCTCATGTTCCCACACACCCTAACG
  GATGCACCACTGCACACAGATACACCCTCTGTGCAATACCCACACACCCACACTCTAAGG
  CAACAGCCACAGTCACACAGGCTCACCGCCAACAGCTGCACTCTTGGACACAGACAGTCT
  TGTAGATCCCTCAGATGCACTCTCCGAGGCAATGTCATCACAGACAATAGCCACACCTTC
  ACACAGAGACATAGCTACATGGATAACAGCCATGGACACACCCTTTGAAAGACGACAGCC
  TCATCTCAAACACAGACACACCCTCACAGGCAACAGGCACTGAGCCACAAGTTCTCATAG
  ACAACAACGGCACTCTCGGATATAGACAGCAGACACACACTCACAACCACTCTCAGACAT
  CGATGCCCTTCAGCAACAACCTTCAGGGCCTCAGACTCACAGACAACAACCACACTTTTG
  GATGCATCCCTCACGGACAGCATTCACAGATGCACACTATCCTACACCATTCTCAGACAT
  GCGTTCTTCCAGACAGCCTTCAGAAACACACTCACAGACATTACTTGCCTGCTCAGATAT
  AGAGCCCCTCATAGACAGCGTTCCAGAACATACCATTGCACACTTGCTTAACACACACAC
  ACACACACATNNCCCTTTGCTGTTGGTGCTCCCAGTCCTGGGACTGTCANGATGGCTGAT
  CAGTGAAGACTGTNCTAGTGGNTGGNCACTNCACACCACTNCAACACCCACAGNCCTGCC
  TNTGAAGTCATAGTGCAAGCCCCAAAGCCCTGCTGGNGACANAACAGTGTCCAGAATGCT
  GGTCTCA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for AK096566 unedited
  GTACCGCGGCCGCATCTANATCGAGTTTTTTTTTTTTTTTTTTTTTTTTTGAAACAGAGT
  CTGCTCTGTCGCCCAGGCTGGAGTGCAATGGCGCTATCTCGGCTCACTGCAATCTCCGCC
  TCCCGGGTTCAAGCGATTCTCCTGTCTCAGCCTCCCCAGTAGCTGGGACTACAGGCGCCC
  GCCACCACGCGAGGCTAATTTGTTGTATTTCTAGTAGAGCCGGGGTTTCACCGTGATAGC
  CAGGACTGCCGGCCTCACGCTTTTTAACACCAACTTCAAACGACTTGGGCTGGTGTCCCA
  GCCAGGCCGCGCACCCGCACAGCACAGCACAGCGGCCCCCGTCCCCCTCGCCCCGCCGCA
  CCCTGCCGCGCCCACTCACCCTGACCGGGAAGCTGCACGTGCCCTTCCGCACCGCGTCCT
  CGTCTGCCTGCCACTGGTGCGGGCGCGACGCCTCGGGCACGTAGGCTGGCTTCCTCCGCC
  GCAGGCTCTGCCGTAACTTGTTCATGGTGCCCGCCCCGTCTGGTGACACAGGACAGTGAT
  GTGGGTCAAGGGTGGGGGTCAGAAGGTATGGAGCTCAACGGGGAGGGACCAGTGCTCANG
  GAGCATGGGGTCAGATAACAAGATAACTGGAAGCGGNGTTACAGGGTCAGTTGGCAGCGC
  ACATGGGATCAGCAGCTCAAGTCAGGGGACAGTGAGGAAAAGAGCCCACAGAAGCCAGGG
  GAGTGCGAAAGTTGGCACTGGGATTCAGACCATGGGGCTAAGGGGCTGGAGTCTGGGGTG
  GGGGTATGGGCACAGGCTTCAGGCATTGGAGGGCTCTTGCCATGTGGGGGATGCTCCTCA
  TCCCAGGGCCCTGAAGACACAAGGTGGGAAATAAACTTAGAAGGCATGGGGCTAAGGGAT
  AAAATAGGGGCCCACGGCCGGGGTTTATGGGTTAAGATCAGCCCGGGGGATCAGAGCACC
  CAAGATTGGGATGCTGGTTCGGT
  
• Restriction Sites: NotI-NotI
• ACCN: AK096566
• ORF Size: 2064 bp
• Insert Size: 2000
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: AK096566.1
• RefSeq Size: 2064
• RefSeq ORF: 2064
• Locus ID: 9253
• Protein Pathways: Notch signaling pathway
• Gene Summary: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. [UniProtKB/Swiss-Prot Function]