Cytochrome P450 2D6 (CYP2D6) (NM_000106) Human Untagged Clone

CAT#: SC104446

CYP2D6 (untagged)-Human cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CYP2D6
• Synonyms: CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_000106 edited
  TCGGCACGAGGCCTGGTCCTCTGTGCCTGGTGGGGTGGGGGTGCCAGGTGTGTCCAGAGG
  AGCCCATTTGGTAGTGAGGCAGGTATGGGGCTAGAAGCACTGGTGCCCCTGGCCGTGATA
  GTGGCCATCTTCCTGCTCCTGGTGGACCTGATGCACCGGCGCCAACGCTGGGCTGCACGC
  TACTCACCAGGCCCCCTGCCACTGCCCGGGCTGGGCAACCTGCTGCATGTGGACTTCCAG
  AACACACCATACTGCTTCGACCAGTTGCGGCGCCGCTTCGGGGACGTGTTCAGCCTGCAG
  CTGGCCTGGACGCCGGTGGTCGTGCTCAATGGGCTGGCGGCCGTGCGCGAGGCGCTGGTG
  ACCCACGGCGAGGACACCGCCGACCGCCCGCCTGTGCCCATCACCCAGATCCTGGGTTTT
  GGGCCGCGTTCCCAAGGGGTGTTCCTGGTGCGCTATGGGCCCGCGTGGCGCGAGCAGAGG
  CGCTTCTCCGTCTCCACCTTGCGCAACTTGGGCCTGGGCAAGAAGTCGCTGGAGCAGTGG
  GTGACCGAGGAGGCCGCCTGCCTTTGTGCCGCCTTCGCCAACCACTCCGGACGCCCCTTT
  CGCCCCAACGGTCTCTTGGACAAAGCCGTGAGCAACGTGATCGCCTCCCTCACCTGCGGG
  CGCCGCTTCGAGTACGACGACCCTCGCTTCCTCAGGCTGCTGGACCTAGCTCAGGAGGGA
  CTGAAGGAGGAGTCGGGCTTTCTGCGCGAGGTGCTGAATGCTGTCCCCGTCCTCCTGCAT
  ATCCCAGCGCTGGCTGGCAAGGTCCTACGCTTCCAAAAGGCTTTCCTGACCCAGCTGGAT
  GAGCTGCTAACTGAGCACAGGATGACCTGGGACCCAGCCCAGCCCCCCCGAGACCTGACT
  GAGGCCTTCCTGGCAGAGATGGAGAAGGCCAAGGGGAACCCTGAGAGCAGCTTCAATGAT
  GAGAACCTGCGCATAGTGGTGGCTGACCTGTTCTCTGCCGGGATGGTGACCACCTCGACC
  ACGCTGGCCTGGGGCCTCCTGCTCATGATCCTACATCCGGATGTGCAGCGCCGTGTCCAA
  CAGGAGATCGACGACGTGATAGGGCAGGTGCGGCGACCAGAGATGGGTGACCAGGCTCAC
  ATGCCCTACACCACTGCCGTGATTCATGAGGTGCAGCGCTTTGGGGACATCGTCCCCCTG
  GGTGTGACCCATATGACATCCCGTGACATCGAAGTACAGGGCTTCCGCATCCCTAAGGGA
  ACGACACTCATCACCAACCTGTCATCGGTGCTGAAGGATGAGGCCGTCTGGGAGAAGCCC
  TTCCGCTTCCACCCCGAACACTTCCTGGATGCCCAGGGCCACTTTGTGAAGCCGGAGGCC
  TTCCTGCCTTTCTCAGCAGGCCGCCGTGCATGCCTCGGGGAGCCCCTGGCCCGCATGGAG
  CTCTTCCTCTTCTTCACCTCCCTGCTGCAGCACTTCAGCTTCTCGGTGCCCACTGGACAG
  CCCCGGCCCAGCCACCATGGTGTCTTTGCTTTCCTGGTGACCCCATCCCCCTATGAGCTT
  TGTGCTGTGCCCCGCTAGAATGGGGTACCTAGTCCCCAGCCTGCTCCCTAGCCAGAGGCT
  CTAATGTACAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_000106 unedited
  NNNNNGGGGGNNNNNNCCCCCCNNGGNNCGGTTCAGATTTGTATACGACTCACTATAGGC
  GGCCGCGATTCGGCACGAGGCCTGGTCCTCTGTGCCTGGTGGGGTGGGGGTGCCAGGTGT
  GTCCAGAGGAGCCCATTTGGTAGTGAGGCAGGTATGGGGCTAGAAGCACTGGTGCCCCTG
  GCCGTGATAGTGGCCATCTTCCTGCTCCTGGTGGACCTGATGCACCGGCGCCAACGCTGG
  GCTGCACGCTACTCACCAGGCCCCCTGCCACTGCCCGGGCTGGGCAACCTGCTGCATGTG
  GACTTCCAGAACACACCATACTGCTTCGACCAGTTGCGGCGCCGCTTCGGGGACGTGTTC
  AGCCTGCAGCTGGCCTGGACGCCGGTGGTCGTGCTCAATGGGCTGGCGGCCGTGCGCGAG
  GCGCTGGTGACCCACGGCGAGGACACCGCCGACCGCCCGCCTGTGCCCATCACCCAGATC
  CTGNGTTTTGGGCCGCGTTCCCAAGGGGTGTTCCTGGTGCGCTATGGGCCCGCGTGGCGC
  GAGCAGAGGCGCTTCTCCGTCTCCACCTTGCGCAACTTGGGCCTGGGCAAGAAGTCGCTG
  GAGCAGTGGGTGACCGAGGAGGCCGCCTGCCTTTGTGCCGCCTTCGCCAACCACTCCGGA
  CGCCCCTTTCGCCCCAACGGTCTCTTGGACAAAGCCGTGAGCAACGTGATCGCCTTCCTC
  ACCTGCGGGCGCCGCTTCGAGTACGACGACCCTCGCTTCCTCAGGCTGCTGGACCTAGCT
  CANGAGGGNACTGAGNGANGAGTCGGGCTTTCTGNCGCGAGGTGCTGAAATGCTGTCCCC
  GTCCTTCTGCATATCCCAGCGCTGGCTGGNNCAGGTCCTACGCTTCCAAAGGCTTNTCTG
  ACCCANCTGNATGAGCTGCTACTGAGCCAGGATGACCTGGGN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_000106 unedited
  NNTTTTACTCTGNAACCGCGGCCGCAATCTAANGATCGATTTTTTTTTTTTTTTTTTTTT
  TTTTTTTTTTTTTTTTTTTGGAACTACCACATTGCTTTATTGGACATTAAAACCTCTGGC
  TAAGGAACAAGCTGGGGACTAAGTACCCCATTTTAACGGGGCACAACACAAAACTCATAA
  GGGGATGGGGTCACCAAGAAAGCAAAAACACCCTGGGGGCTGGGCCCGGGCTGTCCAATG
  GGCACCCAAAAACTTAAATGCTTCACCAGGGAGGGGAAAAAAAAGAAAAACTCCATGCGG
  GCCAAGGGCTCCCCCAAGCATGCACCGGGGCCTGCTTAAAAAAGCAAGAAAGCCTCCCGC
  TTTACAAAATGGCCCTGGGCATTCAAAAAATGTTCCGGGTGGAAACCGAAAGGGTTTTTC
  CAAAAGGGCTTATTCTTTAACACCCAAAAAAAGTTGGGGAAGAATGTCCTTCCCTTAAGG
  AAGCGGAAACCCTGTACTTTGATGTCACGGGATGTCATATGGGTCACACCCAAGGGGACC
  ATGTCCCCAAAACGCTGCACCTCATGAATCACCGCAATGGTGTAAGGCATGTGAACCTGG
  TCACCCATTTTTGGTCGCCGCACCTGCCCTATTACGTTGTCGATCTCCTGTTGGACACCG
  GGCTTCACATTCCGATGTAAGATCATTAACAAGAAGCCCCAAGCCAACGTGGGTCGAAGT
  GGTCACCATTCCGGCAGAGAACAGGTCAACCACCACTATGCCGCAAGGTCTCATCATTGA
  AACTGCTCTTCAAGGGTTCCCTTGGCCTTCTTCATCTCTGCCAGAAAGCCTTAATCAGTC
  TCCGGGGGGGCCTGGGCCTGTGTCCAAGTCATCCTGGCCTCAATTAACACTATTCAGCTG
  GGGTCAGAAAGCCTTTTGGAAACCTAAGACCCTGCCAACACGCTGAATTCCCCAAGAAAC
  GA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_000106
• Insert Size: 2000 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_000106.4, NP_000097.2
• RefSeq Size: 1673 bp
• RefSeq ORF: 1494 bp
• Locus ID: 1565
• Cytogenetics: 22q13.2
• Domains: p450
• Protein Families: Druggable Genome, P450, Transmembrane
• Protein Pathways: Drug metabolism - cytochrome P450
• Gene Summary: 'This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]'
  Transcript Variant: This variant (1) encodes the longer isoform (1).