Complement factor B (CFB) (AH001502) Human Untagged Clone
CAT#: SC105978
(untagged)-Human MHC class III gene, factor B, Bb fragment
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Specifications
Product Data | |
Type | Human Untagged Clone |
Tag | Tag Free |
Symbol | CFB |
Synonyms | AHUS4|ARMD14|BF|BFD|CFAB|CFBD|FB|FBI12|GBG|H2-Bf|PBF2 |
Vector | pCMV6-XL5 |
E. coli Selection | Ampicillin (100 ug/mL) |
Mammalian Cell Selection | None |
Sequence Data |
>NCBI ORF sequence for AH001502, the custom clone sequence may differ by one or more nucleotides
CAAATGATCGATGAAAGCCAGTCTCTGAGTCTCTGTGGCATGGTTTGGGAACACAGGAAGGGTACCGATT ACCACAAGCAACCATGGCAGGCCAAGATCTCAGTCATTCGCCCTTCAAAGGGCCACGAGAGCTGTATGGG GGCTGTGGTGTCTGAGTACTTTGTGCTGACAGCAGCACATTGTTTCACTGTGGATGACAAGGAACACTCA ACTAAGGTCAGCGTAGGAGGGGAGAAGCGGNNNNNNNNNATAGAAGTAGTCCTATTTCACCCCAACTACA ACATTAATGGGAAAAAAGAAGCAGGAATTCCCGAATTTTATGACTATGACGTTGCCCTGATCAAGCTCAA GAATAAGCTGAAATATGGCCAGACCATCAGGCCCATTCTGAAGGAGAAACTCCAAGATGAGGATTTGGGT TTTCATTAAGGGGTTTTCTGCTGAACAGGGGCGTGGGATTGAATTAAAACAGCTGCGACAAC >OriGene 5' read for AH001502 unedited
GGGGTTTANNATTAGNATACGACTCATATAGGCGGCCGCGAAATTCGCACGAGGAAAACC TGTTGCTCATTGTCTTTCTTGGAAGCCAAAGCATTGATGTTCAAAGTTAAGGATATGGAA AACCTGGAAGATGTTTTCTACCAAATGATCGATGAAAGCCAGTCTCTGAGTCTCTGTGGC ATGGTTTGGGAACACAGGAAGGGTACCGATTACCACAAGCAACCATGGCAGGCCAAGATC TCAGTCATTCGCCCTTCAAAGGGACACGAGAGCTGTATGGGGGCTGTGGTGTCTGAGTAC TTTGTGCTGACAGCAGCACATTGTTTCACTGTGGATGACAAGGAACACTCAATCAAGGTC AGCGTAGGAGGGGAGAAGCGGGACCTGGAGATAGAAGTAGTCCTATTTCACCCCAACTAC AACATTAATGGGAAAAAAGAAGCAGGAATTCCTGAATTTTATGACTATGACGTTGCCCTG ATCAAGCTCAAGAATAAGCTGAAATATGGCCAGACTATCAGGCCCATTTGTCTCCCCTGC ACCGAGGGAACAACTCGAGCTTTGAGGCTTCCTCCAACTACCACTTGCCAGCAACAAAAG GAAGAGCTGCTCCCTGCACAGGATATCAAAGCTCTGTTTGTGTCTGAGGAGGAGAAAAAG CTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTGTGAGAGAGAT GCTCAATATGCCCCAGGCTATGACAAAGTCAAGGACATCTCAGAGGTGGTCACCCCTCGG TTCCTTTGTACTGGAGGAGTGAGTCCCTATGCTGACCCCAATACTGCAAGGTGATTCTGC GGCCCTTGTAGTCACAGAGAGTCGTTATTCAGTTGTGTATCACTGGGAGTAGTGATGTCT CAAAACAGAGCGCAAGCAGTACTGTACGCGATATACT >OriGene 3' read for AH001502 unedited
GTTCAGCTATGNNACCGCGGCCGCAATCTAGNGATCGGTTTTTTTTTTTTTTTTTTGTTG TCGCAGCTGTTTTAATTCAATCCCACGCCCCTGTCCAGCAGGAAACCCCTTATAGAAAAC CCAAATCCTCATCTTGGAGTTTCTCCTTCAGCCAGGGCAGCACTTGAAAGAGGTTGATGT GAAAGTCTCGGGCGTGAGCAGGTACCTGCTTTTGCCGCTTCTGGTTTTTGCAGACATCCA CTACTCCCCAGCTGATTACACCAACTTGAATGAAACGACTTCTCTTGTGAACTATCAAGG GGCCGCCAGAATCACCTCTGCAAGTATTGGGGTCAGCATAGGGACTCACTCCTCCAGTAC AAAGGAACCGAGGGGTGACCACCTCTGAGATGTCCTTGACTTTGTCATAGCCTGGGGCAT ATTGAGCATCTCTCTCACAGCTGCCTTTCTTATCCCCATTCTTGATGTAGACCTCCTTCC GAGTCAGCTTTTTCTCCTCCTCAGACACAAACAGAGCTTTGATATCCTGTGCAGGGAGCA GCTCTTCCTTTTGTTGCTGGCAAGTGGTAGTTGGAGGAAGCCTCAAAGCTCGAGTTGTTC CCTCGGTGCAGGGGAGACAAATGGGCCTGATAGTCTGGCCATATTTCAGCTTATTCTTGA GCTTGATCAGGGCAACGTCATAGTCATAAAATTCAGGAATTCCTGCTTCTTTTTTCCCAT TAATGTTGTAGTTGGGGTGAAATANGACTACTTCTATCTNCAGGTCCCGCTTCTCCCTCC TACGCTGACCTTGATTGAGTGGTCCTTGTCATCCACAGTGGACCAATGTGCTGCTGTCAG CCCAAGTACTCAGAACCACAGCCCCCATACGCTCTCGTGTCCCTTTGAGGGCGATGACTG AGATCTTGGCCTGCCATGGNTGCTGTGGAAAN |
Restriction Sites | NotI-NotI |
ACCN | AH001502 |
Insert Size | 1150 bp |
OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
Product Components | The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones. |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | AH001502.1, AAA36219.1 |
RefSeq Size | 482 bp |
RefSeq ORF | 482 bp |
Locus ID | 629 |
Cytogenetics | 6p21.33 |
Protein Families | Druggable Genome, Protease, Secreted Protein |
Protein Pathways | Complement and coagulation cascades |
Gene Summary | 'This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]' |
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