Complement factor B (CFB) (AH001502) Human Untagged Clone

CAT#: SC105978

(untagged)-Human MHC class III gene, factor B, Bb fragment


Reconstitution Protocol

USD 1,180.00

2 Weeks*

Size
    • 10 ug

Product Images

Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol CFB
Synonyms AHUS4|ARMD14|BF|BFD|CFAB|CFBD|FB|FBI12|GBG|H2-Bf|PBF2
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for AH001502, the custom clone sequence may differ by one or more nucleotides


CAAATGATCGATGAAAGCCAGTCTCTGAGTCTCTGTGGCATGGTTTGGGAACACAGGAAGGGTACCGATT
ACCACAAGCAACCATGGCAGGCCAAGATCTCAGTCATTCGCCCTTCAAAGGGCCACGAGAGCTGTATGGG
GGCTGTGGTGTCTGAGTACTTTGTGCTGACAGCAGCACATTGTTTCACTGTGGATGACAAGGAACACTCA
ACTAAGGTCAGCGTAGGAGGGGAGAAGCGGNNNNNNNNNATAGAAGTAGTCCTATTTCACCCCAACTACA
ACATTAATGGGAAAAAAGAAGCAGGAATTCCCGAATTTTATGACTATGACGTTGCCCTGATCAAGCTCAA
GAATAAGCTGAAATATGGCCAGACCATCAGGCCCATTCTGAAGGAGAAACTCCAAGATGAGGATTTGGGT
TTTCATTAAGGGGTTTTCTGCTGAACAGGGGCGTGGGATTGAATTAAAACAGCTGCGACAAC


>OriGene 5' read for AH001502 unedited
GGGGTTTANNATTAGNATACGACTCATATAGGCGGCCGCGAAATTCGCACGAGGAAAACC
TGTTGCTCATTGTCTTTCTTGGAAGCCAAAGCATTGATGTTCAAAGTTAAGGATATGGAA
AACCTGGAAGATGTTTTCTACCAAATGATCGATGAAAGCCAGTCTCTGAGTCTCTGTGGC
ATGGTTTGGGAACACAGGAAGGGTACCGATTACCACAAGCAACCATGGCAGGCCAAGATC
TCAGTCATTCGCCCTTCAAAGGGACACGAGAGCTGTATGGGGGCTGTGGTGTCTGAGTAC
TTTGTGCTGACAGCAGCACATTGTTTCACTGTGGATGACAAGGAACACTCAATCAAGGTC
AGCGTAGGAGGGGAGAAGCGGGACCTGGAGATAGAAGTAGTCCTATTTCACCCCAACTAC
AACATTAATGGGAAAAAAGAAGCAGGAATTCCTGAATTTTATGACTATGACGTTGCCCTG
ATCAAGCTCAAGAATAAGCTGAAATATGGCCAGACTATCAGGCCCATTTGTCTCCCCTGC
ACCGAGGGAACAACTCGAGCTTTGAGGCTTCCTCCAACTACCACTTGCCAGCAACAAAAG
GAAGAGCTGCTCCCTGCACAGGATATCAAAGCTCTGTTTGTGTCTGAGGAGGAGAAAAAG
CTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTGTGAGAGAGAT
GCTCAATATGCCCCAGGCTATGACAAAGTCAAGGACATCTCAGAGGTGGTCACCCCTCGG
TTCCTTTGTACTGGAGGAGTGAGTCCCTATGCTGACCCCAATACTGCAAGGTGATTCTGC
GGCCCTTGTAGTCACAGAGAGTCGTTATTCAGTTGTGTATCACTGGGAGTAGTGATGTCT
CAAAACAGAGCGCAAGCAGTACTGTACGCGATATACT
>OriGene 3' read for AH001502 unedited
GTTCAGCTATGNNACCGCGGCCGCAATCTAGNGATCGGTTTTTTTTTTTTTTTTTTGTTG
TCGCAGCTGTTTTAATTCAATCCCACGCCCCTGTCCAGCAGGAAACCCCTTATAGAAAAC
CCAAATCCTCATCTTGGAGTTTCTCCTTCAGCCAGGGCAGCACTTGAAAGAGGTTGATGT
GAAAGTCTCGGGCGTGAGCAGGTACCTGCTTTTGCCGCTTCTGGTTTTTGCAGACATCCA
CTACTCCCCAGCTGATTACACCAACTTGAATGAAACGACTTCTCTTGTGAACTATCAAGG
GGCCGCCAGAATCACCTCTGCAAGTATTGGGGTCAGCATAGGGACTCACTCCTCCAGTAC
AAAGGAACCGAGGGGTGACCACCTCTGAGATGTCCTTGACTTTGTCATAGCCTGGGGCAT
ATTGAGCATCTCTCTCACAGCTGCCTTTCTTATCCCCATTCTTGATGTAGACCTCCTTCC
GAGTCAGCTTTTTCTCCTCCTCAGACACAAACAGAGCTTTGATATCCTGTGCAGGGAGCA
GCTCTTCCTTTTGTTGCTGGCAAGTGGTAGTTGGAGGAAGCCTCAAAGCTCGAGTTGTTC
CCTCGGTGCAGGGGAGACAAATGGGCCTGATAGTCTGGCCATATTTCAGCTTATTCTTGA
GCTTGATCAGGGCAACGTCATAGTCATAAAATTCAGGAATTCCTGCTTCTTTTTTCCCAT
TAATGTTGTAGTTGGGGTGAAATANGACTACTTCTATCTNCAGGTCCCGCTTCTCCCTCC
TACGCTGACCTTGATTGAGTGGTCCTTGTCATCCACAGTGGACCAATGTGCTGCTGTCAG
CCCAAGTACTCAGAACCACAGCCCCCATACGCTCTCGTGTCCCTTTGAGGGCGATGACTG
AGATCTTGGCCTGCCATGGNTGCTGTGGAAAN
Restriction Sites NotI-NotI     
ACCN AH001502
Insert Size 1150 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq AH001502.1, AAA36219.1
RefSeq Size 482 bp
RefSeq ORF 482 bp
Locus ID 629
Cytogenetics 6p21.33
Protein Families Druggable Genome, Protease, Secreted Protein
Protein Pathways Complement and coagulation cascades
Gene Summary 'This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]'

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.