FBXO11 (AF174599) Human Untagged Clone

CAT#: SC106306

(untagged)-Human F-box protein Fbx11 (FBX11) mRNA, partial cds

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: FBXO11
• Synonyms: FBX11|PRMT9|UBR6|UG063H01|VIT1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for AF174599, the custom clone sequence may differ by one or more nucleotides
  
  
  CGGCCGCGCCCGGTGCAGCAACAGCAGCAGCAGCCCCCGCAGCAGCCGCCGCCGCAGCCGCCCCAGCAGC
  AGCCGCCCCAGCAGCAGCCTCCGCCGCCGCCGCAGCAGCAGCAGCAGCAGCAGCCTCCGCCGCCGCCACC
  GCCGCCTCCGCCGCTGCCTCAGGAGCGGAACAACGTCGGCGAGCGGGATGATGATGTGCCTGCAGATATG
  GTTGCAGAAGAATCAGGTCCTGGTGCACAAAATAGTCCATACCAACTTCGTAGAAAAACTCTTTTGCCGA
  AAAGAACAGCGTGTCCCACAAAGAACAGTATGGAGGGCGCCTCAACTTCAACTACAGAAAACTTTGGTCA
  TCGTGCAAAACGTGCAAGAGTGTCTGGAAAATCACAAGATCTATCAGCAGCACCTGCTGAACAGTATCTT
  CAGGAGAAACTGCCAGATGAAGTGGTTCTAAAAATCTTCTCTTACTTGCTGGAACAGGATCTTTGTAGAG
  CAGCTTGTGTATGTAAACGCTTCAGTGAACTTGCTAATGATCCCAATTTGTGGAAACGATTATATATGGA
  AGTATTTGAATATACTCGCCCTATGATGCAT
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for AF174599 unedited
  TTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCTCCTGCCCCGAA
  GCTCGCTGTGCGTGTGCGTGTGTGTGTCCCTCCGCCAACGCCGCCACCTCAGCCCGGCAA
  ATGAACTCCGTCCGAGCCGCCAACCGGAGACCCAGGCGAGTGTCGCGGCCGCGCCCGGTG
  CAGCAACAGCAGCAGCAGCCCCCGCAGCAGCCGCCGCCGCAGCCGCCCCAGCAGCAGCCG
  CCCCAGCAGCAGCCTCCGCCGCCGCCGCAGCAGCAGCAGCAGCAGCAGCCTCCGCCGCCG
  CCACCGCCGCCTCCGCCGCTGCCTCAGGAGCGGAACAACGTCGGCGAGCGGGATGATGAT
  GTGCCTGCAGATATGGTTGCAGAAGAATCAGGTCCTGGTGCACAAAATAGTCCATACCAA
  CTTCGTAGAAAAACTCTTTTGCCGAAAAGAACAGCGTGTCCCACAAAGAACAGTATGGAG
  GGCGCCTCAACTTCAACTACAGAAAACTTTGGTCATCGTGCAAAACGTGCAAGAGTGTCT
  GGAAAATCACAAGATCTATCAGCAGCACCTGCTGAACAGTATCTTCAGGAGAAACTGCCA
  GATGAAGTGGTTCTAAAAATCTTCTCTTACTTGCTGGAACAGGATCTTTGTAGAGCAGCT
  TGTGTATGTAAACGCTTCAGTGAACTTGCTAATGATCCAATTTTGTGGAAACGATTATAT
  ATGGAAGTATTTGAATATACTCGCCCTATGATGCATCCTGAACCTGGAAAATTCTACCAG
  ATTAATCCAGAAGAGTATGAACATCCAAATCCCTGGAAAAGAGAGTTCCAGCANGTGTAT
  AANAGTGCACATNGTAAGCCAGGATTTGCTGAACATTTCTACAGTACN
  
• Restriction Sites: NotI-NotI
• ACCN: AF174599
• ORF Size: 591 bp
• Insert Size: 1250
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: AF174599.1, AAF04520.1
• RefSeq Size: 591
• RefSeq ORF: 591
• Locus ID: 80204
• Domains: F-box
• Protein Families: Druggable Genome
• Gene Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]