DOCK2 (NM_004946) Human Untagged Clone

CAT#: SC107268

DOCK2 (untagged)-Human dedicator of cytokinesis 2 (DOCK2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DOCK2
• Synonyms: IMD40
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_004946, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCCCCCTGGCGCAAAGCTGACAAGGAGCGGCACGGCGTGGCCATATACAACTTCCAAGGCAGCGGAG
  CCCCCCAGCTCTCCCTGCAGATCGGCGATGTGGTGCGAATACAGGAGACGTGTGGAGACTGGTATAGGGG
  ATACCTCATAAAGCACAAAATGTTACAGGGCATTTTTCCTAAGTCATTTATCCACATCAAGGAAGTGACA
  GTTGAGAAAAGAAGAAATACTGAGAACATCATTCCTGCAGAAATTCCTCTGGCACAAGAAGTGACAACGA
  CACTTTGGGAATGGGGAAGCATCTGGAAACAACTCTATGTGGCCAGCAAAAAGGAGCGTTTTCTCCAGGT
  GCAGTCCATGATGTACGATCTGATGGAGTGGAGGTCCCAGCTTCTCTCAGGAACCTTACCCAAGGATGAG
  CTGAAGGAACTGAAGCAGAAAGTCACGTCCAAAATTGACTATGGCAACAAAATCCTTGAGCTTGATTTGA
  TTGTCAGAGATGAAGACGGAAATATCTTGGACCCTGATAATACCAGTGTCATCAGCTTGTTCCATGCACA
  TGAGGAAGCAACTGATAAAATCACAGAGCGTATCAAAGAAGAAATGTCAAAAGACCAGCCAGATTATGCA
  ATGTATTCCCGGATCTCCTCATCCCCCACCCATAGCCTCTATGTGTTTGTGAGAAACTTTGTGTGCAGAA
  TTGGGGAAGATGCTGAGCTCTTCATGTCTCTCTACGACCCCAACAAGCAAACGGTCATAAGTGAGAACTA
  CCTAGTGCGATGGGGCAGCCGGGGCTTCCCTAAGGAGATTGAGATGCTCAACAATCTGAAGGTGGTCTTC
  ACGGATCTTGGAAACAAAGACCTCAACAGGGATAAAATTTACTTGATTTGTCAAATAGTCCGGGTCGGCA
  AGATGGATCTTAAGGATACTGGTGCAAAGAAGTGCACGCAGGGACTGAGGAGGCCCTTTGGGGTGGCAGT
  TATGGATATAACAGACATCATCAAGGGGAAAGCAGAGAGTGATGAAGAAAAGCAGCACTTCATTCCTTTT
  CACCCGGTTACAGCTGAGAATGACTTCCTACACAGCCTGCTGGGCAAAGTCATAGCCTCCAAGGGGGACA
  GTGGAGGGCAAGGCCTCTGGGTGACCATGAAGATGCTGGTGGGTGACATCATTCAGATTCGCAAGGACTA
  TCCACACCTGGTGGACAGGACCACCGTGGTGGCCAGGAAGCTGGGATTCCCAGAGATCATCATGCCAGGG
  GATGTCAGGAACGACATCTACATTACTCTCTTACAAGGTGACTTTGACAAGTACAACAAGACCACACAGA
  GGAATGTGGAAGTCATCATGTGTGTGTGCGCGGAGGATGGCAAAACGCTGCCTAATGCAATTTGCGTGGG
  AGCAGGGGACAAGCCCATGAATGAGTATCGCTCCGTTGTGTACTATCAAGTCAAACAGCCACGCTGGATG
  GAAACAGTCAAGGTGGCTGTCCCTATTGAAGACATGCAGAGGATCCATCTGCGATTCATGTTTCGACATC
  GGTCATCTCTGGAATCTAAAGATAAAGGAGAAAAGAACTTTGCCATGTCCTATGTGAAGCTGATGAAAGA
  AGATGGGACTACTCTACACGATGGATTCCATGACTTAGTTGTCCTCAAGGGGGACAGCAAGAAGATGGAG
  GATGCCAGCGCATACCTGACCCTTCCTTCTTATCGACACCATGTGGAAAACAAGGGGGCCACGCTGAGCA
  GGAGCTCCAGCAGTGTTGGGGGGCTTTCTGTCAGCTCCCGGGATGTGTTCTCCATTTCCACCCTGGTGTG
  CTCCACAAAGCTCACTCAGAATGTGGGCTTGCTGGGTTTGCTGAAGTGGCGTATGAAGCCTCAACTGCTA
  CAGGAGAATTTAGAAAAGTTGAAGATTGTGGATGGAGAGGAAGTGGTGAAGTTTCTCCAGGATACTCTGG
  ATGCCCTCTTCAACATCATGATGGAGCATTCTCAAAGTGATGAATATGACATCCTCGTCTTTGATGCCTT
  GATTTACATAATAGGACTCATTGCAGACCGGAAATTTCAGCATTTCAACACCGTTCTGGAGGCTTACATC
  CAACAGCATTTCAGTGCGACCTTGGCTTACAAGAAATTGATGACAGTGCTGAAGACTTACTTGGATACCT
  CCAGCAGAGGGGAGCAATGTGAGCCAATCCTAAGAACGCTGAAGGCTTTGGAATATGTGTTCAAGTTCAT
  TGTTCGGTCGAGGACATTATTTTCACAGCTTTATGAAGGCAAAGAACAGATGGAGTTTGAAGAATCCATG
  AGACGGCTCTTTGAATCCATCAACAATCTGATGAAAAGTCAATACAAAACTACCATCCTTTTGCAGGTGG
  CGGCTTTGAAATACATCCCATCTGTCCTGCATGATGTAGAAATGGTCTTTGATGCGAAGTTACTCAGCCA
  ACTCCTGTATGAGTTCTACACCTGCATCCCTCCTGTGAAACTCCAGAAGCAGAAAGTACAGTCTATGAAT
  GAGATAGTCCAGAGCAACCTCTTTAAAAAGCAAGAATGCCGGGACATTCTGCTTCCTGTCATCACCAAAG
  AGCTGAAGGAGCTGCTGGAGCAGAAGGATGACATGCAACACCAGGTCCTGGAGAGGAAGTACTGCGTTGA
  ATTGCTCAACAGCATCTTGGAAGTCCTTAGCTACCAGGATGCGGCCTTCACCTACCACCATATCCAGGAG
  ATCATGGTCCAGCTGCTGCGGACAGTGAACCGGACAGTCATCACCATGGGCCGGGATCACATTCTGATTA
  GTCACTTTGTGGCATGTATGACAGCCATCTTAAACCAGATGGGTGACCAGCACTACTCCTTCTACATTGA
  GACCTTCCAGACCAGCTCTGAACTTGTGGACTTCTTGATGGAGACCTTCATCATGTTCAAGGACCTCATT
  GGAAAGAACGTGTACCCTGGAGACTGGATGGCCATGAGCATGGTTCAAAACAGGGTCTTCCTGAGAGCTA
  TCAACAAGTTTGCAGAAACCATGAACCAGAAGTTCCTAGAACACACGAACTTTGAGTTCCAGCTGTGGAA
  CAACTATTTTCATCTGGCAGTGGCTTTTATCACCCAGGATTCTCTGCAGCTGGAGCAGTTCTCACACGCC
  AAATACAACAAAATCCTGAATAAGTATGGGGACATGAGACGGCTAATTGGCTTCTCCATCCGTGATATGT
  GGTACAAGCTTGGTCAGAACAAAATCTGCTTCATCCCAGGCATGGTAGGACCTATATTAGAGATGACACT
  TATCCCTGAGGCTGAGCTCCGGAAAGCCACCATACCAATCTTCTTCGACATGATGCTGTGTGAATATCAA
  AGAAGTGGGGATTTCAAAAAGTTTGAAAACGAAATCATCCTGAAGCTGGACCACGAGGTAGAAGGGGGCC
  GAGGCGACGAGCAGTACATGCAGCTCCTGGAGTCAATCCTGATGGAATGTGCTGCAGAGCACCCAACCAT
  TGCCAAGTCGGTGGAGAACTTCGTGAACCTGGTCAAAGGCCTCCTGGAGAAGCTGCTGGATTACCGGGGT
  GTGATGACAGATGAGAGCAAAGACAACCGCATGAGCTGCACCGTGAACCTGCTGAATTTCTACAAAGATA
  ACAACAGGGAGGAGATGTACATAAGGTACCTGTACAAACTCCGCGATCTTCACCTGGACTGTGACAATTA
  CACAGAGGCTGCCTACACGCTCCTTCTCCACACCTGGCTTCTCAAGTGGTCGGATGAGCAGTGTGCATCA
  CAGGTCATGCAGACAGGCCAGCAGCACCCCCAGACACACCGGCAGCTGAAGGAGACGCTCTACGAGACCA
  TCATAGGCTACTTTGACAAAGGAAAGATGTGGGAAGAGGCCATAAGTCTGTGCAAGGAGCTGGCGGAACA
  GTACGAGATGGAGATCTTTGACTATGAGCTGCTCAGCCAGAACCTGATCCAGCAGGCAAAATTCTATGAA
  AGCATCATGAAAATCCTCAGGCCCAAACCAGACTACTTTGCTGTTGGATACTACGGCCAGGGATTCCCCT
  CCTTCCTGCGGAACAAAGTGTTCATCTACCGCGGGAAGGAATATGAGCGAAGAGAAGATTTCCAGATGCA
  GCTGATGACCCAGTTCCCCAATGCAGAGAAGATGAACACCACCTCTGCCCCGGGAGATGATGTGAAGAAT
  GCCCCAGGCCAGTATATCCAGTGCTTCACTGTCCAGCCTGTCTTGGATGAACATCCCAGGTTCAAGAATA
  AGCCAGTGCCTGACCAGATTATAAACTTCTACAAATCCAACTACGTGCAAAGGTTCCACTACTCCCGGCC
  CGTGCGCAGGGGGACCGTAGACCCAGAGAATGAGTTTGCTTCCATGTGGATTGAGAGAACCTCCTTCGTG
  ACTGCATACAAGCTGCCGGGGATCCTGCGCTGGTTTGAGGTGGTGCACATGTCGCAGACCACAATTAGTC
  CTCTGGAGAATGCCATAGAAACCATGTCCACGGCCAATGAGAAGATCCTGATGATGATAAACCAGTACCA
  GAGTGATGAGACCCTCCCCATCAACCCACTCTCCATGCTCCTGAACGGGATTGTGGACCCTGCTGTCATG
  GGAGGCTTCGCCAAGTATGAGAAGGCCTTCTTCACTGAAGAGTATGTCAGGGACCACCCTGAGGACCAGG
  ACAAGCTGACCCACCTCAAGGACCTGATTGCATGGCAGATCCCCTTCTTGGGAGCTGGGATTAAGATCCA
  TGAGAAAAGGGTGTCAGATAACTTGCGACCCTTCCATGACCGGATGGAGGAATGTTTCAAGAACCTGAAA
  ATGAAGGTGGAGAAGGAGTACGGTGTCCGAGAGATGCCTGACTTTGACGACAGGAGAGTGGGCCGTCCCA
  GGTCTATGCTGCGCTCATACAGACAGATGTCCATCATCTCTCTGGCTTCCATGAATTCTGACTGCAGCAC
  CCCCAGCAAGCCTACCTCAGAGAGCTTTGACCTGGAATTAGCATCACCCAAGACGCCGAGAGTGGAGCAG
  GAGGAACCGATCTCCCCGGGGAGCACCCTGCCTGAGGTCAAGCTGCGGAGGTCCAAGAAGAGGACAAAGA
  GAAGCAGCGTAGTTTTTGCGGATGAGAAAGCAGCTGCAGAGTCGGACCTGAAGCGGCTTTCCAGGAAGCA
  TGAGTTCATGAGTGACACCAACCTCTCGGAGCATGCGGCCATCCCCCTCAAGGCGTCTGTCCTCTCTCAA
  ATGAGCTTTGCCAGCCAGTCCATGCCTACCATCCCAGCCCTGGCGCTCTCAGTGGCAGGCATCCCTGGGT
  TGGATGAGGCCAACACATCTCCCCGCCTCAGCCAGACCTTCCTCCAACTCTCAGATGGTGACAAGAAGAC
  ACTCACACGGAAGAAGGTCAATCAGTTCTTCAAGACAATGCTGGCCAGCAAATCGGCTGAAGAAGGCAAA
  CAGATCCCAGACTCGCTGTCCACGGACCTGTGA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004946 unedited
  CGCGAATTCGGCACCAGGAAAAGAGGAAGGAAGTGGGGCCCTGCGGCGCCCAGCCACCCC
  CTGACGGCTTCCCCACGGGAGGACGCGAGGCCCCGGCCCAGCCATGGCCCCCTGGCGCAA
  AGCTGACAAGGAGCGGCACGGCGTGGCCATATACAACTTCCAAGGCAGCGGAGCCCCCCA
  GCTCTCCCTGCAGATCGGCGATGTGGTGCGAATACAGGAGACGTGTGGAGACTGGTATAG
  GGGATACCTCATAAAGCACAAAATGTTACAGGGCATTTTTCCTAAGTCATTTATCCACAT
  CAAGGAAGTGACAGTTGAGAAAAGAAGAAATACTGAGAACATCATTCCTGCAGAAATTCC
  TCTGGCACAAGAAGTGACAACGACACTTTGGGAATGGGGAAGCATCTGGAAACAACTCTA
  TGTGGCCAGCAAAAAGGAGCGTTTTCTCCAGGTGCAGTCCATGATGTACGATCTGATGGA
  GTGGAGGTCCCAGCTTCTCTCAGGAACCTTACCCAAGGATGAGCTGAAGGAACTGAAGCA
  GAAAGTCACGTNCAAAATTGACTATGGNCACAAAATCCTTGAGCTTGATTTGATTGTCAG
  AGATGAAGACGGNAATATCTTGGACCCCTGATATACCAGTGTCATCAGCTTGGTCCATGC
  ACATGAGGAANGCACTGATAAAATCACAGAGCGTATCAAAGAGAAATGTCNAAAGACAGC
  CAGATTATGCATGTATCCCGGATCTCTCATA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_004946
• Insert Size: 6000 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_004946.1, NP_004937.1
• RefSeq Size: 6050 bp
• RefSeq ORF: 5493 bp
• Locus ID: 1794
• Cytogenetics: 5q35.1
• Protein Families: Druggable Genome
• Protein Pathways: Chemokine signaling pathway, Fc gamma R-mediated phagocytosis
• Gene Summary: 'The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. Mutations in this gene result in immunodeficiency 40 (IMD40), a combined form of immunodeficiency that affects T cell number and function, also with variable defects in B cell and NK cell function. [provided by RefSeq, May 2018]'